A5085530453- Pancreatic and Hepatic Oncology Research
- Chromatin Remodeling and Cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Mechanisms of cancer metastasis
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Anesthesia and Pain Management
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Endoplasmic Reticulum Stress and Disease
- Circadian rhythm and melatonin
- Cancer Cells and Metastasis
- Nursing Roles and Practices
- Hedgehog Signaling Pathway Studies
- Neuroendocrine Tumor Research Advances
- Pain Mechanisms and Treatments
- Cardiac Structural Anomalies and Repair
- Pain Management and Opioid Use
- Pain Management and Placebo Effect
- Colorectal and Anal Carcinomas
- Nutrition, Genetics, and Disease
- Histone Deacetylase Inhibitors Research
Shahid Beheshti University of Medical Sciences
2025
Shiraz University of Medical Sciences
2019-2025
Western University
2021-2024
Children’s Health Research Institute
2021-2023
Lawson Health Research Institute
2023
Semnan University of Medical Sciences
2023
Yazd University
2015
Shahid Sadoughi University of Medical Sciences and Health Services
2014
Sylvester Comprehensive Cancer Center
2009
University of Miami Hospital
2009
Abstract Background: Lymph node (LN) involvement, as an important prognostic factor in breast cancer (BC) patients, has a crucial role their therapeutic approach. Consequently, great desire is to thoroughly assess the patients based on axillary LN status. The present study evaluated characteristics and survival rate of metastatic BC Tertiary referral center. Method: overall survival, disease-free clinicopathological referred Cancer Research Center Tehran, Iran, from 1991 2022 were assessed...
The purpose of this study is to investigate the trauma hospital preparedness in disasters 2019. A cross-sectional was conducted two qualitative and quantitative phases. Data were collected retrospectively part through census semi-structured interviews. Quantitative data analyzed using descriptive statistics content analysis, respectively. Hazard 2019 divided into categories: natural (floods) man-made (floods, street riots, incidence COVID-19). 93% all hazards attributed spread COVID-19, 5.4%...
<p>Supplementary Figure 8 shows the expression of GLI target genes in all experimental groups.</p>
<p>Supplementary Figure 1 shows correlation of SNP rs1992901 and GLI2 Transcript Expression.</p>
<p>Supplementary Figure 2 describes the characterization of impact Gli2 overexpression in pancreas development. showing that loss has no on development or survival vivo.</p>
<p>Supplementary Figure 3 shows Gli2 expression in CRG and KCRG mice Gli luciferase activity ΔNGli2-transfected cells.</p>
<p>Supplementary Figure 6 describes RNA-seq shows differential gene expression induced by oncogenic KRAS.</p>
<p>Supplementary Figure 7 shows how oncogenic KRAS modulates GLI target gene expression.</p>
<p>Supplementary Figure 9 shows that Gli2 does not change H3K27Ac enrichment at Ccnd1 promoter downstream of oncogenic KRAS.</p>
<p>Supplementary Figure 5 shows the IHC results looking at CD4 and CD8 expression in KC KCRG mice. The show no difference immune landscape between these mouse models.</p>
<p>Supplementary Figure 10 shows not differences in H3K4me1 enrichment at Ccnd1 promoter mutant KRAS cells.</p>
<p>Supplementary Figure 4 shows the validation of Kras signaling activation and chronic pancreatitis phenotypic examples in KC KCRG mice.</p>
Bevacizumab in combination with carboplatin and paclitaxel improves overall response survival patients advanced or recurrent nonsmall cell lung carcinoma. However, this drug is not recommended squamous carcinoma neoplasms a dominant component. Therefore, identification of differentiation has therapeutic implications. In many instances, cytology the diagnostic tool choice; however, routine cytomorphology limited classification carcinomas into nonsquamous subtypes. The aim study was to...
Medullary thyroid carcinoma (MTC) is a neuroendocrine tumor from the para follicular C cells of gland. It occurs either sporadically or as part an inherited syndrome. caused by autosomal dominant mutation in RET (Rearranged during Transfection) proto-oncogene.The studied population consisted 47 patients diagnosed with MTC specific northwest Iran along their three children. Blood samples were collected all subjects, genomic DNA was extracted and exons 10, 11, 13, 14, 15, 16 analyzed using PCR...
Opioid action in the brain involves dopamine-reward system as well non-dopamine pathways. Since vitamin D also modulates brain's dopamine system, question of this study was how might affect opioid influences on reward system. Therefore, objective to investigate possible effect conditioned place preference (CPP) induced by morphine, a valuable model assessment reinforcing properties opioids associating context rewarding addictive drugs. Male Wistar rats were randomly divided into two main...
Introduction. Circadian system is deeply involved in renal function. The circadian timing may be disrupted chronic kidney disease (CKD) patients. Gender differences CKD have been reported. This research aimed to investigate the gender rhythm of inflammatory and oxidant markers CKD. Methods. Male, intact female, ovariectomized (OVX) female rats (twenty-four each group) were randomly assigned control groups. further divided into day (12:00 p.m.) night a.m.) subgroups. Evaluations sample...
Abstract Introduction: Pancreatic ductal adenocarcinoma (PDAC) is currently the 3rd leading cause of cancer-related deaths in North American with ~10% survival 5 years after diagnosis. A contributing factor to this low rate chemotherapy resistance. Major risk factors for PDAC, including smoking and chronic pancreatitis, promote activation unfolded protein response (UPR). The UPR reduces load alleviate stress, cancer cells can utilize cell survival. We previously showed loss Activating...
<p>Supplementary Figure 6 describes RNA-seq shows differential gene expression induced by oncogenic KRAS.</p>