A5100729250- Hearing, Cochlea, Tinnitus, Genetics
- RNA Research and Splicing
- RNA modifications and cancer
- Vestibular and auditory disorders
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Virus-based gene therapy research
- Veterinary Oncology Research
- Cancer-related molecular mechanisms research
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- MicroRNA in disease regulation
- Nutrition, Genetics, and Disease
- Cancer, Hypoxia, and Metabolism
- Viral Infectious Diseases and Gene Expression in Insects
- Insect and Pesticide Research
- Connexins and lens biology
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Estrogen and related hormone effects
- Ion channel regulation and function
- Pesticide Residue Analysis and Safety
- Neuroscience of respiration and sleep
- Cellular transport and secretion
Chinese PLA General Hospital
2016-2025
ZheJiang Institute For Food and Drug Control
2015-2025
National Clinical Research Center for Digestive Diseases
2020-2025
National Clinical Research
2021-2025
Capital University
2025
First Affiliated Hospital of Guangzhou Medical University
2022-2024
Tianjin Medical University Cancer Institute and Hospital
2013-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Agricultural Genomics Institute at Shenzhen
2023-2024
Chinese Academy of Agricultural Sciences
2023-2024
HuR, an RNA binding protein, binds to adenine- and uridine-rich elements (ARE) in the 3'-untranslated region (UTR) of target mRNAs, regulating their stability translation. HuR is highly abundant many types cancer, it promotes tumorigenesis by interacting with cancer-associated which encode proteins that are implicated different tumor processes including cell proliferation, survival, angiogenesis, invasion, metastasis. Drugs disrupt stabilizing effect upon mRNA targets could have dramatic...
Mitofusin-2 (MFN2) is a dynamin-like GTPase that plays central role in regulating mitochondrial fusion and cell metabolism. Mutations MFN2 cause the neurodegenerative disease Charcot-Marie-Tooth type 2A (CMT2A). The molecular basis underlying physiological pathological relevance of unclear. Here, we present crystal structures truncated human different nucleotide-loading states. Unlike other dynamin superfamily members including MFN1, forms sustained dimers even after GTP hydrolysis via...
Musashi‐1 (MSI1) is an RNA‐binding protein that acts as a translation activator or repressor of target mRNAs. The best‐characterized MSI1 Numb mRNA, whose encoded negatively regulates Notch signaling. Additional targets include the mRNAs for tumor suppressor APC Wnt signaling and cyclin‐dependent kinase inhibitor P21WAF−1. We hypothesized increased expression NUMB, P21 APC, through inhibition activity might be effective way to simultaneously downregulate signaling, thus blocking growth broad...
<h3>Background</h3> Auditory neuropathy spectrum disorder (ANSD) is a form of hearing loss in which auditory signal transmission from the inner ear to nerve and brain stem distorted, giving rise speech perception difficulties beyond that expected for observed degree loss. For many cases ANSD, underlying molecular pathology site lesion remain unclear. The X-linked condition, AUNX1, has been mapped Xq23-q27.3, although causative gene yet be identified. <h3>Methods</h3> We performed whole-exome...
Abstract Patients diagnosed with metastatic breast cancer have a dismal 5-year survival rate of only 24%. The RNA-binding protein Hu antigen R (HuR) is upregulated in cancer, and elevated cytoplasmic HuR correlates high-grade tumors poor clinical outcome cancer. promotes tumorigenesis by regulating numerous proto-oncogenes, growth factors, cytokines that support major tumor hallmarks including invasion metastasis. Here, we report inhibitor KH-3, which potently suppresses cell invasion....
Roses are consistently ranked at the forefront in cut flower production. Increasing demands of market and changing climate conditions have resulted need to further improve diversity quality traits. However, frequent hybridization leads highly heterozygous nature, including allelic variants. Therefore, absence comprehensive genomic information them making it challenging molecular breeding. Here, two haplotype-resolved chromosome genomes for Rosa chinensis 'Chilong Hanzhu' (2n = 14) which is...
PTEN has been studied in several tumor models as a suppressor. In this study, we explored the role of inhibition state polarized M2 subtype macrophage microenvironment (TME) and underlying mechanisms. To elucidate potential effect TME, RAW 264.7 macrophages 4T1 mouse breast cancer cells were co-cultured to reconstruct microenvironment. After was down-regulated with shRNA, expression CCL2 VEGF-A, which are definited promote formation macrophages, have dramatically increase on level both gene...
// Amber R. Smith 1 , Rebecca T. Marquez Wei-Chung Tsao Surajit Pathak 3 Alexandria Roy Jie Ping Bailey Wilkerson Lan Wenjian Meng Kristi L. Neufeld 1,4 Xiao-Feng Sun and Liang Xu 1,2 Department of Molecular Biosciences, University Kansas, Lawrence, KS, USA 2 Radiation Oncology, The Kansas Medical Center, City, Clinical Experimental Medicine, Linköping University, Linköping, Sweden 4 Cancer Biology, Correspondence to: Xu, email: Keywords : tumor-initiating cells, microRNAs, RNA-binding...
In designing genome-wide association (GWA) studies it is important to calculate statistical power. General power calculation procedures for quantitative measures often require information concerning summary statistics of distributions such as mean and variance. However, with genetic studies, the effect size traits traditionally expressed heritability, a quantity defined amount phenotypic variation in population that can be ascribed variants among individuals. Heritability hard transform into...
In this study, a five-generation Chinese family (family F013) with progressive autosomal dominant hearing loss was mapped to critical region spanning 28.54 Mb on chromosome 9q31.3-q34.3 by linkage analysis, which novel DFNA locus, assigned as DFNA56. interval, there were 398 annotated genes. Then, whole exome sequencing applied in three patients and one normal individual from family. Six single nucleotide variants two indels found co-segregated the phenotypes. Then using mass spectrum...
Increasing evidence suggests tumor-associated macrophages (TAMs) are polarized M2 subtype of macrophage that exerts pro-tumor effects and promote the malignancy some cancers, but concrete mechanism is not well defined. Our previous research exhibited proto-oncogene AP-1 regulated IL-6 expression in promoted formation macrophages. In this study, we investigate whether extra-cellular stimulus M-CSF help process or nuclear factor NFκB has a synergistic role activation state macrophage. RAW...
The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3'-untranslated region (UTR) of target mRNAs. HuR-ARE interactions stabilize many oncogenic mRNAs that play important roles tumorigenesis. Thus, small molecules interfere with interaction could potentially inhibit cancer cell growth and progression. Using a fluorescence polarization (FP) competition assay, we identified compound azaphilone-9 (AZA-9) derived from fungal natural product asperbenzaldehyde, HuR...
Abstract Monocarboxylate transporter‐4 ( MCT 4), a monocarboxylic acid transporter, demonstrates significantly increased expression in the majority of malignancies. We performed an experiment using BALB /C mice, and our results showed that Sh 4 transfection or pharmaceutic inhibition with 7acc1 strengthens activity NK cells. The calcein assay revealed cytotoxicity cells was strengthened via 4. In addition, ELISA testing content perforin CD 107a increased, PCR amplification immunoblotting NKG...
The RNA-binding protein Hu antigen R (HuR) is a post-transcriptional regulator critical in several types of diseases, including cancer, making it promising therapeutic target. We have identified small-molecule inhibitors HuR through screening approach used combination with fragment analysis. A total 36 new compounds originating from linking or structural optimization were studied to establish structure–activity relationships the set. Two top inhibitors, 1c and 7c, further validated by...
Psoriasis is an inflammatory skin disease that intricately linked to oxidative stress. Antioxidation and inhibition of abnormal proliferation keratinocytes are pivotal strategies for psoriasis. Delivering drugs with these effects the site lesions a challenge needs be solved. Herein, we reported nanotransdermal delivery system composed all-trans retinoic acid (TRA), triphenylphosphine (TPP)-modified cerium oxide (CeO2) nanoparticles, flexible nanoliposomes gels (TCeO2-TRA-FNL-Gel). The...
All stem cells have the ability to balance their production of self-renewing and differentiating daughter cells. The germline cells(GSCs) Drosophila ovary maintain such through physical attachment anterior niche cap stereotypic cell division, whereby only one remains attached niche. GSCs are via adherens junctions, which also appear orient GSC division capture fusome, a germline-specific organizer mitotic spindles. Here we show that Rab11 GTPase is required in GSC-cap junctions anchor fusome...
The present study aimed to investigate whether rhamnetin induced apoptosis in human breast cancer cells and the underlying molecular mechanism of this anti effect. treatment MCF‑7 with was able significantly inhibit cell proliferation induce caspase‑3/9 activity a dose‑ time‑dependent manner, compared untreated cells. In addition, promote expression p53 protein microRNA (miR‑)34a also suppressed Notch1 Subsequently, miR‑24a promoted rhamnetin‑treated using miR‑34a plasmid. overexpression...