A5036860312- RNA modifications and cancer
- Advanced Chemical Physics Studies
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Extracellular vesicles in disease
- Cancer therapeutics and mechanisms
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Cell Adhesion Molecules Research
- Angiogenesis and VEGF in Cancer
- Neuroblastoma Research and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Glycosylation and Glycoproteins Research
- Physics of Superconductivity and Magnetism
- Mesenchymal stem cell research
- Ubiquitin and proteasome pathways
- PI3K/AKT/mTOR signaling in cancer
- Quantum and electron transport phenomena
- Cancer-related molecular mechanisms research
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
Tianjin Medical University Cancer Institute and Hospital
2025
First People's Hospital of Yunnan Province
2025
Kunming University of Science and Technology
2025
Shanghai Medical College of Fudan University
2025
Fudan University Shanghai Cancer Center
2025
Northeast Agricultural University
2014-2024
Xi'an Jiaotong University
2004-2024
Wannan Medical College
2023-2024
Kunming Medical University
2024
Second Affiliated Hospital of Kunming Medical College
2024
We propose a simple analytic representation of the correlation energy ${\mathrm{\ensuremath{\varepsilon}}}_{\mathit{c}}$ for uniform electron gas, as function density parameter ${\mathit{r}}_{\mathit{s}}$ and relative spin polarization \ensuremath{\zeta}. Within random-phase approximation (RPA), this allows ${\mathit{r}}_{\mathit{s}}^{\mathrm{\ensuremath{-}}3/4}$ behavior ${\mathit{r}}_{\mathit{s}}$\ensuremath{\rightarrow}\ensuremath{\infty}. Close agreement with numerical RPA values...
We construct a generalized gradient approximation (GGA) for the density ${\mathit{n}}_{\mathrm{xc}}$(r,r+u) at position r+u of exchange-correlation hole surrounding an electron r, or more precisely its system and spherical average 〈${\mathit{n}}_{\mathrm{xc}}$(u)〉=(4\ensuremath{\pi}${)}^{\mathrm{\ensuremath{-}}1}$\ensuremath{\int}d${\mathrm{\ensuremath{\Omega}}}_{\mathit{u}}$ ${\mathit{N}}^{\mathrm{\ensuremath{-}}1}$\ensuremath{\int}${\mathit{d}}^{3}$r...
The electronic exchange energy as a functional of the density may be approximated ${E}_{x}[n]={A}_{x}\ensuremath{\int}{d}^{3}r{n}^{\frac{4}{3}}F(s)$, where $s=\frac{|\ensuremath{\nabla}n|}{2{k}_{F}n}$, ${k}_{F}={(3{\ensuremath{\pi}}^{2}n)}^{\frac{1}{3}}$, and $F(s)={(1+1.296{s}^{2}+14{s}^{4}+0.2{s}^{6})}^{\frac{1}{15}}$. basis for this approximation is gradient expansion hole, with real-space cutoffs chosen to guarantee that hole negative everywhere represents deficit one electron. Unlike...
For a uniform electron gas of density n=${\mathit{n}}_{\mathrm{\ensuremath{\uparrow}}}$+${\mathit{n}}_{\mathrm{\ensuremath{\downarrow}}}$=3/4\ensuremath{\pi}${\mathit{r}}_{\mathit{s}}^{3}$=\ensuremath{\pi}${\mathit{k}}_{\mathit{s}}^{6}$/192 and spin polarization \ensuremath{\zeta}=(${\mathit{n}}_{\mathrm{\ensuremath{\uparrow}}}$-${\mathit{n}}_{\mathrm{\ensuremath{\downarrow}}}$)/n, we study the Fourier transform...
The pair-distribution function g describes physical correlations between electrons, while its average g\ifmmode\bar\else\textasciimacron\fi{} over coupling constant generates the exchange-correlation energy. former is found from latter by g=(1-${\mathit{a}}_{0}$\ensuremath{\partial}/\ensuremath{\partial}${\mathit{a}}_{0}$)g\ifmmode\bar\else\textasciimacron\fi{}, where ${\mathit{a}}_{0}$ Bohr radius. We present an analytic representation of (and hence g) in real space for a uniform electron...
The mechanisms that promote the generation of new coronary vasculature during cardiac homeostasis and after injury remain a fundamental clinically important area study in cardiovascular field. Recently, it was reported mesenchymal-to-endothelial transition (MEndoT) contributes to substantial numbers endothelial cells myocardial infarction. Therefore, MEndoT has been proposed as paradigm mediating neovascularization is considered promising therapeutic target regeneration. Here, we show...
Abstract The scope and variety of the metabolic intermediates from mitochondrial tricarboxylic acid (TCA) cycle that are engaged in epigenetic regulation chromatin function nucleus raise an outstanding question about how timely precise supply/consumption these metabolites is achieved nucleus. We report here identification a nonclassical TCA (nTCA cycle). found all cycle-associated enzymes including citrate synthase (CS), aconitase 2 (ACO2), isocitrate dehydrogenase 3 (IDH3), oxoglutarate...
The Harbola-Sahni exchange potential is the work needed to move an electron against electric field of its hole charge distribution. We prove that it not exact density-functional theory, by showing yields wrong second-order gradient expansion in slowly varying limit. But we also discover correct local-density approximation. Thus a more physically version Slater potential, one better suited for molecular and solid-state applications. As step our derivation, present third-order density, discuss...
PTEN has been studied in several tumor models as a suppressor. In this study, we explored the role of inhibition state polarized M2 subtype macrophage microenvironment (TME) and underlying mechanisms. To elucidate potential effect TME, RAW 264.7 macrophages 4T1 mouse breast cancer cells were co-cultured to reconstruct microenvironment. After was down-regulated with shRNA, expression CCL2 VEGF-A, which are definited promote formation macrophages, have dramatically increase on level both gene...
Interval cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) showed promising oncologic outcomes for patients advanced ovarian cancer, but a large-scale, multicenter study to evaluate the efficacy of HIPEC primary (PCS) has yet be conducted.To compare survival between PCS vs alone stage III epithelial cancer.This cohort was conducted from January 2010 May 2017 at 5 high-volume institutions in China. A total 584 cancer were treated either or HIPEC. The median...
Acute ischemic stroke (AIS) is a major public health problem inChina.Impaired angiogenesis plays crucial roles in the development of cerebral injury.Recent studies have identified that microRNAs (miRNAs) are important regulators angiogenesis, but little known exact effects angiogenesis-associated miRNAs AIS.In present study, we detected expression levels AIS patients, middle artery occlusion (MCAO) rats, and oxygen-glucose deprivation/reoxygenation (OGD/R) human umbilical vein endothelial...
Tumor angiogenesis plays an important role in the development of cancer. Previously, we reported that hepatitis B X-interacting protein (HBXIP) functioned as oncoprotein breast However, HBXIP cancer remains poorly understood. In present study, show crucial roles event. We observed expression levels were positively correlated with those fibroblast growth factor 8 (FGF8) or vascular endothelial (VEGF) clinical tissues. Then, demonstrated was able to upregulate FGF8 through activation its...
// Rui Li 1, * , Gu Yanjiao 2, He Wubin 3 Wang Yue 4 Huang Jianhua 5 Zheng Huachuan 6 Su Rongjian 7 Luan Zhidong 8 1 Department of Cell Biology, College Basic Medicine, Jinzhou Medical University, Jinzhou, China 2 Pathology, The First Affiliated Hospital Life Science Institute Medicine Biology and Genetic Key Lab Molecular Cellular the Education Liaoning Province, Development These authors have contributed equally to this work Correspondence to: Rongjian, email: rongjiansu@hotmail.com...
Abstract Background Hepatic ischaemia-reperfusion injury (HIRI) is inevitable in complicated liver surgery and a major factor leading to postoperative complications dysfunction. Studies have shown that the paracrine mechanisms of stem cell may be essential tissue repair functional improvement after transplantation. However, role adipose-derived mesenchymal secretome (ASC-secretome) regeneration large animals remains determined. Methods Twenty-four miniature pigs were subjected laparoscopic...
The radiologic and pathologic correlations of subsolid lung cancers are unclear. No study has used the whole-mount sections to analyze correlations. This aims clarify through use analysis. Patients with adenocarcinomas receiving segmentectomy or lobectomy were included. made. same identified. Radiologic tumor solid/invasive sizes compared. Histologic features in solid component ground-glass opacity (GGO) regions evaluated. There 102 patients 20 pure GGO 82 part-solid tumors analyzed. was one...
Although nucleotide analogs (NAs) and interferons are currently the primary treatments for chronic hepatitis B, they do not entirely remove cccDNA from hepatocytes. Antiviral therapy's desired outcome is absence of B surface antigen(HBsAg), often known as a clinical cure. interferon therapy has significantly higher HBsAg clearance serologic conversion rates than NAs, combination or sequential can improve to some extent. Still, only small proportion patients will achieve As result, it...
Background The transcription factor PAX6 is primarily expressed in embryos. also several tumors and plays an oncogenic role. However, little known about the role of lung cancer. Methods function cancer cells was evaluated by small interfering RNA-mediated depletion protein followed analyses cell proliferation, anchorage-independent growth, cycle arrest. changes cyclin D1, pRB, ERK1/2, p38 expression caused inhibition were detected using western-blotting. mRNA level 52 pairs corresponding...
Oxidized low-density lipoprotein (oxLDL) is involved in the pathological phenotypic transformation of vascular smooth muscle cells atherosclerosis. Galectin‑3 also has an important role However, little currently known regarding effects galectin‑3 on oxLDL‑induced cells. In present study, primary culture human umbilical were treated with various oxLDL concentrations (0‑50 µg/ml) for 72 h, and changes subsequently recorded. The results study suggested that increases expression levels...