A5100684696- Hormonal Regulation and Hypertension
- Cardiovascular Health and Risk Factors
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Cardiac Fibrosis and Remodeling
- Microfluidic and Capillary Electrophoresis Applications
- Nanopore and Nanochannel Transport Studies
- Lipoproteins and Cardiovascular Health
- Erythropoietin and Anemia Treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related molecular mechanisms research
- Crystallography and molecular interactions
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pharmacogenetics and Drug Metabolism
- Pharmacological Effects of Natural Compounds
- Renal cell carcinoma treatment
- Medicinal Plants and Bioactive Compounds
- Alzheimer's disease research and treatments
- Adrenal and Paraganglionic Tumors
- Nutrition, Genetics, and Disease
- Caveolin-1 and cellular processes
- Adrenal Hormones and Disorders
- Chronic Kidney Disease and Diabetes
- MicroRNA in disease regulation
- X-ray Diffraction in Crystallography
Nanjing University
2023-2025
Shaanxi University of Science and Technology
2024-2025
Zhejiang Chinese Medical University
2024-2025
Imaging Center
2025
Molecular Sensing (United States)
2025
Shenyang Pharmaceutical University
2013-2024
Chinese PLA General Hospital
2013-2024
Far Eastern Memorial Hospital
2023
Hangzhou Medical College
2023
Yangpu Hospital of Tongji University
2015-2022
Interval cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) showed promising oncologic outcomes for patients advanced ovarian cancer, but a large-scale, multicenter study to evaluate the efficacy of HIPEC primary (PCS) has yet be conducted.To compare survival between PCS vs alone stage III epithelial cancer.This cohort was conducted from January 2010 May 2017 at 5 high-volume institutions in China. A total 584 cancer were treated either or HIPEC. The median...
<h3>Importance</h3> Because of tumor heterogeneity, traditional clinical variables remain insufficient to predict recurrence, which impairs long-term survival among patients undergoing radical hepatectomy for hepatocellular carcinoma (HCC). Vessels encapsulating clusters (VETC) constitute a novel vascular pattern distinct from microvascular invasion (MVI), representing biological aggressiveness HCC. <h3>Objective</h3> To establish model estimate individualized recurrence-free (RFS) in HCC by...
The effect of 5-fluorouracil (5-FU) chemotherapy for gastric cancer (GC) is limited by drug-resistance. To conquer this drug-resistance, various treatments including combination therapy have been used, but the overall survival has not improved yet. In our current study, 5-FU resistant GC cells, SGC7901/FU and MGC803/FU, were established long term exposure to 5-FU, proliferation capability these cells was verified be reduced. drug related proteins, MDR1 P-gp up-regulated in compared parental...
Salvianolic acid A (SAA) is a bioactive polyphenol extracted from Salviae miltiorrhizae Bunge, which possesses variety of pharmacological activities. In our previous study, we have demonstrated that SAA effectively attenuates kidney injury and inflammation in an established animal model 5/6 nephrectomized (5/6Nx) rats. However, there has been limited research regarding the antioxidative effects on chronic disease (CKD). Here, examined underlying mechanisms 5/6Nx The rats were injected with...
Nanopores are promising sensors for glycan analysis with the accurate identification of complex glycans laying foundation nanopore-based sequencing. However, their applicability toward continuous sequencing has not yet been demonstrated. Here, we present a proof-of-concept by combining nanopore technology glycosidase-hydrolyzing reactions. By continuously monitoring changes in characteristic current generated translocation hydrolysis products through nanopore, sequence can be accurately...
Glycans, unlike uniformly charged DNA and compositionally diverse peptides, are typically uncharged exhibit rich stereoisomeric diversity in the glycosidic bonds between two monosaccharide units. This heterogeneity of charge structural complexity present significant challenges for accurate analysis. Herein, we developed a novel single‐molecule oligosaccharide sensor, OmpF nanopore. The natural electroosmotic flow within provides robust driving force unlabeled neutral oligosaccharides,...
Glycans, unlike uniformly charged DNA and compositionally diverse peptides, are typically uncharged exhibit rich stereoisomeric diversity in the glycosidic bonds between two monosaccharide units. This heterogeneity of charge structural complexity present significant challenges for accurate analysis. Herein, we developed a novel single‐molecule oligosaccharide sensor, OmpF nanopore. The natural electroosmotic flow within provides robust driving force unlabeled neutral oligosaccharides,...
Tetrahydropalmatine (THP) regulates mitochondrial function in vascular smooth muscle cells (VSMCs) to prevent or alleviate atherosclerosis (AS), with unclear specific mechanism. AS models were constructed by oxidized low-density lipoprotein (ox-LDL)-treated VSMCs. Cell counting kit-8 for cell viability, wound scratch assay migration, and flow cytometry cycle, intracellular reactive oxygen species, membrane potential (MMP) performed. Malondialdehyde (MDA) superoxide dismutase (SOD) levels...
Glucocorticoids amplify endogenous glucose production in type 2 diabetes by increasing hepatic output. Systemic glucocorticoid blockade lowers levels diabetes, but with several adverse consequences. It has been proposed, never demonstrated, that a liver-selective receptor antagonist (LSGRA) would be sufficient to reduce output (HGO) and restore control diabetic patients minimal systemic side effects. A-348441...
Starting from a rapidly metabolized adamantane 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor 22a, series of E-5-hydroxy-2-adamantamine inhibitors, exemplified by 22d and (+/-)-22f, was discovered. Many these compounds are potent inhibitors 11beta-HSD1 selective over 11beta-HSD2 for multiple species (human, mouse, rat), unlike other reported species-selective series. These have good cellular potency improved microsomal stability. Pharmacokinetic profiling in rodents...
Hepatic blockade of glucocorticoid receptors (GR) suppresses glucose production and thus decreases circulating levels, but systemic antagonism can produce adrenal insufficiency other undesirable side effects. These hepatic responses might be dissected, leading to liver-selective pharmacology, when a GR antagonist is linked bile acid in an appropriate manner. Bile conjugation accomplished with minimal loss binding affinity for GR. The resultant conjugates remain potent cell-based functional...
ABSTRACT Blood–brain tumor barrier (BTB) impedes the transportation of antitumor therapeutic drugs into brain tumors. Its mechanism is still unknown, but learning how to improve BTB permeability critical for drug intervention. Recently, microRNAs (miRNAs) have appeared as regulation factors numerous biologic processes and targets diverse diseases. In this study, we identified that miR‐132‐3p an essential miRNA by increasing transcellular transport through BTB. We found expression was...