A5100456104- Atrial Fibrillation Management and Outcomes
- Cardiac Fibrosis and Remodeling
- Cardiac Arrhythmias and Treatments
- Signaling Pathways in Disease
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
- Venous Thromboembolism Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Blood Pressure and Hypertension Studies
- Cardiac Health and Mental Health
- Heart Rate Variability and Autonomic Control
- Peptidase Inhibition and Analysis
- Cardiac Imaging and Diagnostics
- Protease and Inhibitor Mechanisms
- Cardiovascular Disease and Adiposity
- Antiplatelet Therapy and Cardiovascular Diseases
- Heart Failure Treatment and Management
- Endoplasmic Reticulum Stress and Disease
- Receptor Mechanisms and Signaling
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiomyopathy and Myosin Studies
- Acute Myocardial Infarction Research
- Dental Health and Care Utilization
- Oral microbiology and periodontitis research
- Health Systems, Economic Evaluations, Quality of Life
Hebei Medical University
2021-2024
Medtronic (United States)
2021-2024
Second Hospital of Hebei Medical University
2021-2024
Weatherford College
2024
Shandong University
2024
First Affiliated Hospital of Fujian Medical University
2018-2023
Fujian Medical University
2018-2023
Wuhan University
2010-2023
Gansu University of Traditional Chinese Medicine
2023
Shanxi Medical University
2023
The development of cardiac hypertrophy in response to increased hemodynamic load and neurohormonal stress is initially a compensatory that may eventually lead ventricular dilation heart failure. Regulator G protein signaling 5 (Rgs5) negative regulator protein-mediated by inactivating Gα(q) Gα(i), which mediate actions most known vasoconstrictors. Previous studies have demonstrated Rgs5 expresses among various cell types within mature showed high levels mRNA monkey human tissue Northern blot...
Rationale: Cardiac fibrosis plays a critical role in the pathogenesis of heart failure. Excessive accumulation extracellular matrix (ECM) resulting from cardiac impairs contractile function and increases arrhythmogenicity. Current treatment options for fibrosis, however, are limited, there is clear need to identify novel mediators facilitate development better therapeutics. Exploiting coexpression gene network analysis on RNA sequencing data failing human heart, we identified TXNDC5...
Cardiac hypertrophy is a complex pathological process that involves multiple factors including inflammation and apoptosis. Interferon regulatory factor 7 (IRF7) multifunctional regulator participates in immune regulation, cell differentiation, apoptosis, oncogenesis. However, the role of IRF7 cardiac remains unclear. We performed aortic banding cardiac-specific transgenic mice, knockout wild-type littermates these mice. Our results demonstrated was downregulated banding-induced animal hearts...
<h3>Importance</h3> Many patients with nonvalvular atrial fibrillation (NVAF) are at a high risk of gastrointestinal (GI) bleeding due to conditions including older age; stage III V chronic kidney disease (CKD); HAS-BLED (hypertension, or liver disease, stroke history, prior bleeding, unstable international normalized ratio, age >65, drug alcohol use) score 3 greater; corticosteroid, antiplatelet nonsteroidal anti-inflammatory (NSAID) use; GI conditions. <h3>Objective</h3> To compare the...
Signal regulatory protein-α (SIRPA/SIRPα) is a transmembrane protein that expressed in various tissues, including the heart. Previous studies have demonstrated SIRPA involved multiple biological processes, macrophage multinucleation, skeletal muscle differentiation, neuronal survival, protection against diabetes mellitus, and negative regulation of immune cells. However, role cardiac hypertrophy remains unknown. To examine pathological hypertrophy, we used knockout mice transgenic...
The objective of this study was to assess the clinical feasibility generating 3D printing models left atrial appendage (LAA) using real-time transesophageal echocardiogram (TEE) data for preoperative reference LAA occlusion.Percutaneous occlusion can effectively prevent patients with fibrillation from stroke. However, anatomical structure is so complicated that adequate information its essential successful occlusion. Emerging technology has demonstrated potential more accurately than...
Rationale: Extracellular matrix (ECM) remodeling, a key pathological feature in diabetic cardiomyopathy (DCM), is triggered by oxidative stress, inflammation, and various metabolic disorders the heart.Cardiac fibroblasts (CFs) are primary source of ECM proteins ultimate effector cells remodeling.CFs turned on differentiated into myofibroblasts response to profibrotic signaling.Rnd3 small Rho-GTPase involved regulation cell-cycle distribution, cell migration, morphogenesis.Emerging evidence...
Fibrosis caused by the increase in extracellular matrix cardiac fibroblasts plays an important role occurrence and development of atrial fibrillation (AF). The aim this study was to investigate hsa-miR-4443 AF, human fibroblast (HCFB) proliferation, remodeling. TaqMan Stem-loop miRNA assay used measure expression patients with persistent AF (n=123) healthy controls (n=100). Patients were confirmed have fibrosis late gadolinium enhancement. At cellular level, after mimic inhibitor transfected...
Depression is of increasing concern as its prevalence increases. Our study’s objective was to create and evaluate a nomogram predict the likelihood that hypertension patients may experience depression. 13293 people with who were under 20 years old chosen from National Health Nutrition Examination Survey (NHANES) database between 2007 2018 for this study. The training validation sets split up into dataset at random in 7:3 ratio. To find independent predictors, univariate multivariate logistic...
The purpose of this study was to develop and validate a machine learning (ML) based prediction model for the risk heart failure (HF) in patients with prediabetes or diabetes.We used 3527 subjects aged 40 years older prior diagnosis diabetes from National Health Nutrition Examination Survey (NHANES) 2007 2018. search independent variables linked HF conducted using univariate multivariable logistic regression analysis. were randomly divided into training set validation 7:3 ratio. Five ML...
IIn nt tr ro od du uc ct ti io on n: : Thromboembolism, usually originating from the left atrium (LA) and atrial appendage (LAA), is a major complication of fibrillation may result in transient ischemic attack stroke.Computed tomography (CT) noninvasive test for detection LA LAA thrombus.We sought to conduct meta-analysis evaluate accuracy CT detecting LA/LAA thrombus.M Ma at te er ri ia al l an nd d m me et th ho ds s: The PubMed, Medline, ISI Web Knowledge Cochrane Library databases up...
The goal of this study was to assess the effects N-methyl-d-aspartate (NMDA) receptors activation on heart rate variability (HRV) and susceptibility atrial fibrillation (AF).Rats were randomized for treatment with saline, NMDA (agonist receptors), or plus MK-801 (antagonist receptors) 2 weeks. Heart evaluated by using implantable electrocardiogram telemeters. Atrial assessed programmed stimulation in isolated hearts. Compared controls, NMDA-treated rats displayed a decrease standard...
Increased d-dimer is indicative of a hypercoagulable state and found to be associated with acute coronary syndromes. The present study aimed evaluate whether plasma levels could predict subsequent major clinical events in patients artery disease (CAD). First, 2209 angiographic-proven CAD were consecutively enrolled. Then, all subjected follow up for an average 18 months (ranged from 14 1037 days). relationships the severity future outcomes evaluated. We that was higher prior myocardial...
Purpose 3,3′-Diindolylmethane (DIM) is a natural component of cruciferous plants. It has strong antioxidant and anti-angiogenic effects promotes the apoptosis variety tumor cells. However, little known about critical role DIM on cardiac hypertrophy. In present study, we investigated Methods Multiple molecular techniques such as Western blot analysis, real-time PCR to determine RNA expression levels hypertrophic, fibrotic oxidative stress markers, histological analysis including H&E for...
Periostin is an extracellular matrix protein involved in tumorigenesis and metastasis. However, the role of serum periostin as a surrogate marker for treatment efficacy still unknown. In 122 advanced non–small cell lung cancer cases, 37 patients with benign disease 40 healthy controls, was measured by enzyme-linked immunosorbent assays. The associations levels clinic-pathological parameters, chemotherapy response, clinical outcomes were analyzed. Serum significantly higher patients, it...
Regulator of G protein signaling 3 (RGS3) is a negative regulator protein-mediated signaling. RGS3 has previously been shown to be expressed among various cell types within the mature heart. Basic and clinical studies have reported abnormal expressions in hypertrophic hearts failing myocardium. However, role cardiac remodeling remains unclear. In this study, we investigated effect overexpression human on hypertrophy induced by aortic banding (AB) transgenic mice wild-type littermates. The...
Transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective cation channel with high permeability to Ca2+. Intracellular Ca2+ signaling an essential regulator of endothelial nitric oxide (NO) synthase (eNOS) that plays beneficial role in myocardial fibrosis. The aim the present study was determine TRPV1 isoproterenol-induced Transgenic mice overexpressing were generated on C57BL/6J genetic background. An animal model fibrosis created by subcutaneously injecting isoproterenol....
Summary Background Aging is associated with higher incidence of heart failure and death following myocardial infarction ( MI ). The molecular cellular changes that lead to these worse outcomes are not known. Methods Results Young aging mice underwent induction by LAD ligation. There was a significant increase in mortality the mice. Neither young nor hearts after had inducible ventricular tachycardia. Cardiomyocyte apoptosis increases early mice, but much greater degree Caspase inhibition A...
(1) Background: This study aimed to investigate the effect of an additional catheter ablation (CA) procedure on risk post-procedure adverse events during CA combined with left atrial appendage closure (LAAC). (2) Methods: From July 2017 February 2022, data from 361 patients fibrillation who underwent LAAC at our center were analyzed retrospectively. The compared between + and LAAC-only groups. (3) Results: incidence device-related thrombus (DRT) embolic was significantly lower in group than...