A5077553067- Geological and Geochemical Analysis
- Endoplasmic Reticulum Stress and Disease
- Geochemistry and Geologic Mapping
- Geological Studies and Exploration
- Cardiac Fibrosis and Remodeling
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Chronic Kidney Disease and Diabetes
- Connective Tissue Growth Factor Research
- Pharmacological Effects of Natural Compounds
- earthquake and tectonic studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Colorectal Cancer Treatments and Studies
- Energy and Environment Impacts
- Saffron Plant Research Studies
- Coastal and Marine Dynamics
- Methane Hydrates and Related Phenomena
- Gut microbiota and health
- Tryptophan and brain disorders
- Genetic factors in colorectal cancer
- Acute Myeloid Leukemia Research
- Radioactive element chemistry and processing
- Nanoparticle-Based Drug Delivery
- Geochemistry and Elemental Analysis
- Renal Diseases and Glomerulopathies
Washington University in St. Louis
2018-2025
National Taiwan University
2011-2024
National Taiwan University Hospital
2018
University of Chicago
2018
Lung cancer in East Asia is characterized by a high percentage of never-smokers, early onset and predominant EGFR mutations. To illuminate the molecular phenotype this demographically distinct disease, we performed deep comprehensive proteogenomic study on prospectively collected cohort Taiwan, representing stage, predominantly female, non-smoking lung adenocarcinoma. Integrated genomic, proteomic, phosphoproteomic analysis delineated attributes hallmarks tumor progression. Mutational...
Abstract Pulmonary fibrosis (PF) is a major public health problem with limited therapeutic options. There clear need to identify novel mediators of PF develop effective therapeutics. Here we show that an ER protein disulfide isomerase, thioredoxin domain containing 5 (TXNDC5), highly upregulated in the lung tissues from both patients idiopathic pulmonary and mouse model bleomycin (BLM)-induced PF. Global deletion Txndc5 markedly reduces extent preserves function mice following BLM treatment....
Rationale: Cardiac fibrosis plays a critical role in the pathogenesis of heart failure. Excessive accumulation extracellular matrix (ECM) resulting from cardiac impairs contractile function and increases arrhythmogenicity. Current treatment options for fibrosis, however, are limited, there is clear need to identify novel mediators facilitate development better therapeutics. Exploiting coexpression gene network analysis on RNA sequencing data failing human heart, we identified TXNDC5...
Renal fibrosis, a common pathological manifestation of virtually all types chronic kidney disease (CKD), often results in diffuse scarring and predisposes to end-stage renal disease. Currently, there is no effective therapy against fibrosis. Recently, our laboratory identified an ER-resident protein, thioredoxin domain containing 5 (TXNDC5), as critical mediator cardiac Transcriptome analyses biopsy specimens from patients with CKD revealed marked TXNDC5 upregulation fibrotic kidneys,...
Background and objectives Liver fibrosis (LF) occurs following chronic liver injuries. Currently, there is no effective therapy for LF. Recently, we identified thioredoxin domain containing 5 (TXNDC5), an ER protein disulfide isomerase (PDI), as a critical mediator of cardiac lung fibrosis. We aimed to determine if TXNDC5 also contributes LF its potential therapeutic target Design Histological transcriptome analyses on human cirrhotic livers were performed. Col1a1-GFP Tg ,...
The prevalence of obesity in the United States has continued to increase over past several decades. Understanding how diet-induced modulates mucosal immunity is clinical relevance. We previously showed that consumption a high fat, sugar "Western" diet (WD) reduces density and function small intestinal Paneth cells, epithelial cell type with innate immune function. hypothesized could also result repressed gut adaptive immunity. Using intraepithelial lymphocytes (IEL) as readout, we found...
Abstract Objectives: Mesenchymal-type colorectal cancer (CRC), characterized by strong stromal infiltration and immune tolerance, resists checkpoint blockade has poor outcomes. Cancer-associated fibroblasts (CAFs), abundant in tumor stroma, actively remodel the extracellular matrix (ECM), modulate evasion, drive progression. We have recently identified thioredoxin domain-containing protein 5 (TXNDC5), a disulfide isomerase (PDI), as critical mediator of fibroblast activation ECM remodeling...
polymorphisms (G2019S/N2081D) that increase susceptibility to Parkinson's disease and Crohn's (CD) lead LRRK2 kinase hyperactivity suppress autophagy. This connection suggests inhibition, a therapeutic strategy being explored for disease, may also benefit patients with CD. Paneth cell homeostasis is tightly regulated by autophagy, their dysfunction precursor gut inflammation in Here, we found CD mice carrying hyperactive
Introduction: Cardiac fibrosis plays a critical role in fostering heart failure (HF). Excessive accumulation of extracellular matrix (ECM) resulting from cardiac impairs contractile function and increases arrhythmogenicity. Current treatment options for fibrosis, however, are limited. Exploiting RNA sequencing data human failing co-expression gene network analysis, we identified thioredoxin domain containing 5 (TXNDC5), fibroblast (CF)-enriched endoplasmic reticulum (ER) protein, as...
QRS-T angle was calculated from the 10 second ECG as total cosine R-to-T (TCRT) using singular value decomposition with aid of custom written software and is expressed in degrees.Abnormal defined 100o.Follow up until death, transplantation, or most recent dialysis session.Follow censored at transplantation.End points were death major cardiac events (MACE: acute coronary syndrome, revascularisation, hospitalisation due to heart failure arrhythmia, sudden death).The association TCRT 100o these...
INTRODUCTION AND AIMS: Renal fibrosis is the common pathological manifestation of virtually all types chronic kidney disease (CKD).Regardless underlying etiology, progressive renal often results in diffuse scarring that predisposes to end-stage (ESRD), a devastating condition requires dialysis or transplantation.Currently, there no effective therapy treat reverse fibrosis.It is, therefore, imperative identify novel mediators pathways are critical for pathogenesis develop therapeutics.Our...