A5046381266- Autophagy in Disease and Therapy
- Immune Cell Function and Interaction
- RNA modifications and cancer
- IL-33, ST2, and ILC Pathways
- Liver physiology and pathology
- Spine and Intervertebral Disc Pathology
- MicroRNA in disease regulation
- Eicosanoids and Hypertension Pharmacology
- Medical Imaging and Analysis
- Digestive system and related health
- Advanced Glycation End Products research
- Eosinophilic Esophagitis
- Acute Kidney Injury Research
- Orthopaedic implants and arthroplasty
- Diabetes and associated disorders
- Tryptophan and brain disorders
- Macrophage Migration Inhibitory Factor
- Cardiac Arrest and Resuscitation
- Child Nutrition and Water Access
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic function and diabetes
- Gut microbiota and health
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Infant Nutrition and Health
- Chronic Kidney Disease and Diabetes
Washington University in St. Louis
2023-2024
Air Force Medical University
2014
Xijing Hospital
2014
British Geriatrics Society
2008
Twin Cities Orthopedics
1995
University of Minnesota
1995
Dysregulation of transcription factors (TFs) is associated with tumor progression, but little known about TF expression patterns in the context gastric cancer (GC) metastasis. Using array-based profile analysis, we found that 22 TFs showed differential activities between GC cell lines low- and high-metastatic potential. Of this group TFs, serum response factor (SRF) was significantly upregulated metastatic cells. SRF frequently elevated a panel cells tissues, high-level more aggressive...
Abstract Paneth cells (PCs), a specialized secretory cell type in the small intestine, are increasingly recognized as having an essential role host responses to microbiome and environmental stresses. Whether how commensal pathogenic microbes modify PC composition modulate inflammation remain unclear. Using newly developed PC‐reporter mice under conventional gnotobiotic conditions, we determined transcriptomic heterogeneity response invasive at single level. Infection expands pool of CD74 +...
SUMMARY Advanced glycation end‐products (AGE) and their receptors (RAGE) have been implicated in renal damage diabetes. The aim of the present study was to investigate effects benazepril, an angiotensin‐converting enzyme inhibitor (ACEI), on formation AGE, expression RAGE other associated components oxidative stress pathway spontaneously hypertensive rats (SHR). Groups SHR were treated with or without 10 mg/kg per day benazepril for 12 weeks. Systolic blood pressure (SBP) angiotensin (Ang)...
The prevalence of obesity in the United States has continued to increase over past several decades. Understanding how diet-induced modulates mucosal immunity is clinical relevance. We previously showed that consumption a high fat, sugar "Western" diet (WD) reduces density and function small intestinal Paneth cells, epithelial cell type with innate immune function. hypothesized could also result repressed gut adaptive immunity. Using intraepithelial lymphocytes (IEL) as readout, we found...
Environmental enteric dysfunction (EED) is a diffuse small bowel disorder associated with poor growth, inadequate responses to oral vaccines, and nutrient malabsorption in millions of children worldwide. We identify loss the intestinal Paneth goblet cells that are critical for innate immunity, reduced villous height, increased bile acids, dysregulated nicotinamide adenine dinucleotide (NAD + ) synthesis signaling as potential mechanisms underlying EED which also correlated diminished...
polymorphisms (G2019S/N2081D) that increase susceptibility to Parkinson's disease and Crohn's (CD) lead LRRK2 kinase hyperactivity suppress autophagy. This connection suggests inhibition, a therapeutic strategy being explored for disease, may also benefit patients with CD. Paneth cell homeostasis is tightly regulated by autophagy, their dysfunction precursor gut inflammation in Here, we found CD mice carrying hyperactive