A5082217911- Bone health and osteoporosis research
- Gut microbiota and health
- Bone Metabolism and Diseases
- Bone Tissue Engineering Materials
- Vitamin D Research Studies
- Growth Hormone and Insulin-like Growth Factors
- Parathyroid Disorders and Treatments
- Birth, Development, and Health
- Hemoglobinopathies and Related Disorders
- Fibroblast Growth Factor Research
- Diet and metabolism studies
- Dental Implant Techniques and Outcomes
- Iron Metabolism and Disorders
- Trace Elements in Health
- Probiotics and Fermented Foods
- Adipose Tissue and Metabolism
- Pregnancy and preeclampsia studies
- biodegradable polymer synthesis and properties
- COVID-19 Clinical Research Studies
- Alzheimer's disease research and treatments
- Facial Trauma and Fracture Management
- Regulation of Appetite and Obesity
- Magnesium in Health and Disease
- Oral microbiology and periodontitis research
- Infant Nutrition and Health
Mahidol University
2015-2025
Rutgers, The State University of New Jersey
2021-2024
Thammasat University Hospital
2023
Rutgers New Jersey Medical School
2022-2023
Czech Academy of Sciences, Institute of Physiology
2012
United States Bone and Joint Initiative
2010
The lactogenic hormone prolactin (PRL) directly regulates osteoblast functions in vitro and modulates bone remodeling nulliparous rats, but its osteoregulatory roles pregnant lactating rats with physiological hyperprolactinemia remained unclear. Herein, changes were investigated treated bromocriptine (Bromo), an inhibitor of pituitary PRL release, or Bromo+PRL at different reproductive phases, from mid-pregnancy to late lactation. receptors strongly expressed osteoblasts lining trabeculae,...
Despite being widely recognized as the important bone-derived phosphaturic hormone, whether fibroblast growth factor (FGF)-23 modulated intestinal calcium absorption remained elusive. Since FGF-23 could reduce circulating level of 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃], probably compromised 1,25(OH)₂D₃-induced absorption. may also exert an inhibitory action directly through FGF receptors (FGFR) in cells. Herein, we demonstrated by Ussing chamber technique that male mice administered 1 μg/kg...
Abstract Paneth cells (PCs), a specialized secretory cell type in the small intestine, are increasingly recognized as having an essential role host responses to microbiome and environmental stresses. Whether how commensal pathogenic microbes modify PC composition modulate inflammation remain unclear. Using newly developed PC‐reporter mice under conventional gnotobiotic conditions, we determined transcriptomic heterogeneity response invasive at single level. Infection expands pool of CD74 +...
BACKGROUND & AIMS: Lacticaseibacillus rhamnosus GG (LGG) is the world's most consumed probiotic but its mechanism of action on intestinal permeability and differentiation along with interactions an essential source signaling metabolites, dietary tryptophan, are unclear.METHODS: Untargeted metabolomic transcriptomic analyses were performed in LGG monocolonized germ-free (GF) mice fed tryptophan (trp)-free or -sufficient diets.LGG-derived metabolites profiled vitro under anaerobic aerobic...
An earlier study reported that cecal calcium absorption contributes less than 10% of total absorbed by the intestine, although cecum has highest transport rate compared with other intestinal segments. Thus, physiological significance pertaining to body metabolism remains elusive. Herein, a 4-wk balance in cecectomized rats revealed an increase fecal loss marked decreases fractional and urinary excretion only early days post-operation, suggesting presence compensatory mechanism minimize...
Abstract BACKGROUND Breastfeeding leads to bone calcium loss for milk production, resulting in progressive maternal osteopenia. Calcium supplement from natural sources has been postulated be more beneficial health than purified CaCO 3 because also contain other nutrients such as certain amino acids that might enhance metabolism. Herein, we examined the effect of supplementation tuna powder and on bones dams offspring. RESULTS Both forms supplement, i.e. , increased mineral density (BMD)....
Oral calcium and plus vitamin D supplements are commonly prescribed to several groups of patients, e.g., osteoporosis, fracture, deficiency. Adequate steady extracellular levels essential for neuronal activity, whereas certain forms supplement (e.g., CaCO 3 ) probably interfere with memory function. However, it was unclear whether a long-term use ionized (calcium chloride in drinking water ad libitum ), (oral gavage) or the combination both affected anxiety memory, latter which dependent on...
Both Type 2 diabetes mellitus (T2DM) and estrogen deprivation have been shown to be associated with the development of cardiovascular disease adverse cardiac remodeling. However, role on remodeling in nonobese T2DM rats has not clearly elucidated. We hypothesized that estrogen-deprivation aggravates Goto-Kakizaki (GK) rats. Wild-type (WT) GK at age 9 months old were divided into two subgroups either a sham operation (WTS, GKS) or bilateral ovariectomy (WTO, GKO) (n = 6/subgroup). Four after...
Type 2 diabetes mellitus (T2DM) often occurs concurrently with high blood cholesterol or dyslipidemia. Although T2DM has been hypothesized to impair bone microstructure, several investigations showed that, when compared age-matched healthy individuals, patients had normal relatively mineral density (BMD). Since and lipids profoundly affect the function of osteoblasts osteoclasts, it might be that obscured changes in BMD microstructure T2DM. The present study, therefore, aimed determine...
Previously, β-thalassemia, an inherited anemic disorder with iron overload caused by loss-of-function mutation of β-globin gene, has been reported to induce osteopenia and impaired whole body calcium metabolism, but the pathogenesis aberrant homeostasis remains elusive. Herein, we investigated how β-thalassemia intestinal absorption whether it could be restored administration 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] or hepcidin, latter which was liver-derived antagonist absorption. The results...
In the present study, composite scaffolds of chitosan-graft-poly(methyl methacrylate) (Chi-g-PMMA) and mineral ions-loaded hydroxyapatite (mHA) (obtained by hydrothermal treatment (HA) in a simulated body fluid (SBF) solution (mHA@Chi-g-PMMA)) were prepared blending method. The physical properties, bioactivity, biological properties their capabilities for sustained drug protein release studied. Physicochemical analysis showed successful incorporation ions HA particles good distribution mHA...
The present study aimed to test the hypothesis that testosterone deprivation impairs osteoblastic insulin signaling, decreases osteoblast survival, reduces bone density, and obesity aggravates those deleterious effects in testosterone-deprived rats. Twenty four male Wistar rats underwent either a bilateral orchiectomy (O, n=12) or sham operation (S, n=12). Then each group were further divided into two subgroups fed with normal diet (ND) high-fat (HF) for 12 weeks. At end of protocol, blood...