A5031594239- Bone Tissue Engineering Materials
- Bone Metabolism and Diseases
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Bone health and treatments
- Bone health and osteoporosis research
- Oral microbiology and periodontitis research
- Mesenchymal stem cell research
- Dental Health and Care Utilization
- RNA modifications and cancer
- Orthodontics and Dentofacial Orthopedics
- Cancer-related gene regulation
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related molecular mechanisms research
- Dental Radiography and Imaging
- dental development and anomalies
- Parathyroid Disorders and Treatments
- Oral and gingival health research
- Osteoarthritis Treatment and Mechanisms
- Fibroblast Growth Factor Research
- Pituitary Gland Disorders and Treatments
- Healthcare and Venom Research
- Diet, Metabolism, and Disease
- Hemostasis and retained surgical items
- Dental Erosion and Treatment
Mahidol University
2016-2025
Sichuan University
2016
Harvard University
2010-2011
Erasmus MC
2009
Abstract N6‐methyladenosine (m 6 A) modification, installed by METTL3‐METTL14 complex, is abundant and critical in eukaryotic mRNA. However, its role oral mucosal immunity remains ambiguous. Periodontitis a special but prevalent infectious disease characterized as hyperinflammation of mucosa bone resorption. Here, it reported that genetic deletion Mettl3 alleviates periodontal destruction via suppressing NLRP3 inflammasome activation. Mechanistically, the stability TNFAIP3 (also known A20)...
Abstract Hyperprolactinemia is one of the risk factor decrease in bone mass which has been believed to be mediated by hypogonadism. However, presence prolactin receptor human osteosarcoma cell line and primary culture from mouse calvariae supported hypothesis a direct (PRL) action on cells. Therefore, aim this study was investigate role PRL its signal transduction pathway regulation metabolism via osteoblast differentiation. Human pre‐osteoblasts (SV‐HFO) that differentiate 3‐week period...
To evaluate the efficacy of a toothpaste containing amine compound, 0.5% zinc lactate, and 1400 ppm F (NaF) in comparison to regular fluoride 1450 as MFP/NaF (negative control). Plaque gingivitis indices were determined over 6-month period. In randomized, double-blind, two-cell, parallel-group design on healthy adults from Bangkok, Thailand area presenting with initial (Löe-Silness gingival index ≥ 1) visible plaque (Turesky Modification-Quigley-Hein 1.5) assigned test negative control...
Abstract Prolactin (PRL) enhanced bone remodeling leading to net loss in adult and gain young animals. Studies PRL‐exposed osteoblasts derived from humans revealed an increase the expression ratio of receptor activator nuclear factor κB ligand (RANKL) osteoprotegerin (OPG), thus supporting previous finding PRL‐induced adults. This study investigated effects PRL on osteoblast functions RANKL/OPG human fetal (hFOB) cells which strongly expressed receptors. After 48 h incubation, increased...
Jansen metaphyseal chondrodysplasia (JMC) is caused by a constitutively activating mutation of the parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor (PTHR1) and characterized widening metaphyses, reduction long bone length, short stature. A transgenic mouse expressing this under collagen α1(II) promoter has been generated to investigate mechanisms responsible for chondrodysplasia. We recently identified zinc finger 521 (Zfp521) as downstream target gene PTHrP signaling....
Background/purpose Resonance frequency analysis (RFA) is clinically used in dentistry to access the stiffness of dental implants surrounding bone. However, clear advantages and disadvantages this method are still inconclusive. The aim study was investigate compare implant stability quotient (ISQ) values obtained from RFA with parameters a cone beam computed tomography (CBCT) scan same region. Materials methods Nineteen (Conelog) were inserted posterior maxillary mandibular partially...
Abstract Chronic kidney disease (CKD) has been regarded as a risk for bone health. The aim of this study was to evaluate the effect CKD on defect repair in rats. Uremia induced by subtotal renal ablation and serum levels BUN PTH were significantly elevated four weeks after second surgery. Calvarial defects 5-mm diameter created implanted with or without deproteinized bovine mineral (DBBM). Micro-CT histological analyses consistently revealed decreased newly regenerated volume rats 4 8 weeks....
To analyze physicochemical such as surface structures, the crystallinity, chemical composition, calcium phosphate dissolution and osteogenic properties of tooth derived bone substitute (TDBS) processed chair-side other grafting materials. The number anaerobic facultative bacteria in supernatant TDBS was determined. Human osteoblasts were co-cultured with or allograft transwell system to examine cell migration. BMP2 released from measured by ELISA. had high crystallinity similar BoneCeramic...
Type 2 diabetes mellitus (T2DM) often occurs concurrently with high blood cholesterol or dyslipidemia. Although T2DM has been hypothesized to impair bone microstructure, several investigations showed that, when compared age-matched healthy individuals, patients had normal relatively mineral density (BMD). Since and lipids profoundly affect the function of osteoblasts osteoclasts, it might be that obscured changes in BMD microstructure T2DM. The present study, therefore, aimed determine...
Chronic kidney disease (CKD) has been regarded as a grave public health problem. Estrogen is critical factor for both renal protection and bone remodeling. Our previous study demonstrated that CKD impairs the healing of titanium implants. The aim this was to investigate effects estrogen deficiency on mandibular in mice.Forty eleven-week-old female C57BL mice were used study. Uremia induced by 5/6 nephrectomy ovariectomy (OVX), respectively. After 8 weeks, sacrificed, their mandibles...
Chronic kidney disease (CKD) patients, especially those with end stage renal (ESRD) undergoing hemodialysis (HD), exhibit high prevalence of periodontitis. This cross-sectional study aimed to investigate the periodontal status HD patients and its relationship salivary microbiome.One hundred eight one healthy control individuals were recruited. They subjected examination followed by saliva samples collection for 16S rRNA gene sequencing.The worse health status, exhibited higher microbial...
Prolactin is an important hormone involved in the interaction between maternal, extraembryonic, and fetal tissues that remains high levels during entire duration of pregnancy. Although many systemic alterations occur pregnancy, such as hormonal changes, are known to be associated with periodontitis tooth loss, PRL function human periodontal ligament fibroblasts (HPDLF) had never been studied. Herein, we investigated role regulation HPDLF proliferation differentiation. were cultured...
Objective: The purpose of this investigation was to examine the effect resorbable collagen plug (RCP) on bone regeneration in rat calvarial critical-size defects. Methods: About 5-mm-diameter defects were created forty 12-week-old male Sprague-Dawley rats and implanted with or without RCP. Animals killed at 1, 2, 4, 8 weeks postoperatively. After being killed, specimens collected subjected micro-computed tomography (μCT) histological analysis. Results: μCT showed a significant increase newly...
Introduction: Implant surface modification methods have recently involved laser treatment to achieve the desired implant characteristics. Meanwhile, could potentially introduce foreign elements during manufacturing process. Objectives: The study aimed investigate chemistry and topography of commercially available laser-modified titanium implants, together with evaluating cell morphology adhesion human fetal osteoblast (hFOB) seeded onto same implants. Method: Six (6) samples implants were...
METTL5 is a methyltransferase that mediates eukaryotic 18S ribosomal RNA m6A modification, and its mutations lead to intellectual disability, microcephaly, facial dysmorphism in patients. However, the role of craniofacial development remains poorly understood. This study demonstrates Mettl5 knockout mice exhibit poor ossification, widened cranial sutures, cleidocranial dysplasia-like phenotype. Deletion leads increased proliferation decreased osteogenic differentiation suture mesenchymal...
Abstract Background Periodontitis often leads to progressive destruction and loss of alveolar bone, the reconstruction which remains difficult in periodontal therapy. As a novel bone graft material, tooth-derived substitute (TDBS) processed from extracted teeth has been previously reported about its osteoconductivity promising results regeneration. This study was investigate biological effects regeneration properties TDBS vitro vivo using rat defect model. Methods Three groups materials were...
The marginal bone loss that usually observed around dental implant has been well documented and expected. It related with self-reaction to the forensic body of each patient as osseointegrated interface. Bone quantity quality site may help define implant-bone interface, which in turn affects primary stability immediate placement. Analysis prior surgery provides vital information during treatment planning for implant. Additionally, it helps predicting postsurgical success. classification...