A5109138715- Atmospheric chemistry and aerosols
- Atmospheric Ozone and Climate
- Atmospheric and Environmental Gas Dynamics
- Bone health and osteoporosis research
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Bone Tissue Engineering Materials
- Wound Healing and Treatments
- Air Quality and Health Impacts
- Air Quality Monitoring and Forecasting
- Cancer Research and Treatments
- Healthcare and Venom Research
- Parathyroid Disorders and Treatments
- Genomics, phytochemicals, and oxidative stress
- Cancer-related molecular mechanisms research
- Acupuncture Treatment Research Studies
- Bone Metabolism and Diseases
- Traditional Chinese Medicine Studies
- Kruppel-like factors research
- Thyroid Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Ginseng Biological Effects and Applications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Synthesis and Biological Evaluation
- Medicinal Plant Pharmacodynamics Research
Tianjin Medical University Cancer Institute and Hospital
2015-2025
Sichuan University
2016-2025
West China Hospital of Sichuan University
2025
Peking University
2024
Shanghai Traditional Chinese Medicine Hospital
2019-2024
China Meteorological Administration
2010-2023
Sun Yat-sen Memorial Hospital
2017-2020
Sun Yat-sen University
2017-2020
State Key Laboratory of Oral Diseases
2016-2020
Southern Medical University
2020
Abstract Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to dysfunction of marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) an essential intermediate tricarboxylic acid (TCA) cycle. Studies have revealed that αKG extends lifespan worms maintains pluripotency embryonic stem (ESCs). Here, we show administration increases mass aged mice, attenuates age-related loss, accelerates regeneration rodents....
Abstract Osteoporosis is an age-related disease that affects millions of people. Growth differentiation factor 11 (GDF11) a secreted member the transforming growth beta (TGF-β) superfamily. Deletion Gdf11 has been shown to result in skeletal anterior–posterior patterning disorder. Here we show role for GDF11 bone remodelling. treatment leads loss both young and aged mice. inhibits osteoblast also stimulates RANKL-induced osteoclastogenesis through Smad2/3 c-Fos-dependent induction Nfatc1 ....
Abstract Wound healing in diabetic skin is impaired by excessive activation of matrix metalloproteinase-9 (MMP-9). MMP-9 transcription activated Ten-eleven translocation 2 (TET2), a well-known DNA demethylation protein that induces promoter tissues. However, how TET2 targeted to specific loci the unknown. Here, we identified TET2-interacting long noncoding RNA (TETILA) upregulated human TETILA regulates subcellular localization and enzymatic activity, indirectly activating demethylation....
161 Background: Patients (Pts) with mCRPC have a poor prognosis limited treatment options, particularly those who progressed after novel hormonal agents (NHA) and chemotherapy. CBP-1018 has demonstrated well-tolerated safety profile based on 112 pts preliminary efficacy in at RP2D of 0.14mg/kg as shown 2024ASCO 2024ESMO. Here we report the updated data 120 ≥0.14mg/kg including treated prior 2 nd generation androgen receptor pathway inhibitor (ARPI) taxane from Phase I/II study. Methods: In...
Impaired wound healing is one of the main causes diabetic foot ulcerations. However, exact mechanism delayed in diabetes not fully understood. Long noncoding RNAs (lncRNAs) are widely involved a variety biological processes and diseases, including its associated complications. In this study, we identified novel lncRNA, MRAK052872, named lncRNA UpRegulated Diabetic Skin (lnc-URIDS), which regulates diabetes. lnc-URIDS was highly expressed skin dermal fibroblasts treated with advanced...
Halogenated gases include ozone-depleting substances and greenhouse gases, such as chlorofluorocarbons, halons, hydrochlorofluorocarbons, hydrofluorocarbons, perfluorinated gases. In situ atmospheric observations of major halogenated were conducted at the Shangdianzi (SDZ) background station, China, from October 2020 to September 2021 using ODS5-pro, a newly developed measurement system. The time series 36 showed occasional pollution events, where conditions represented 25% (CH2Cl2) 81%...
Diabetes elevates matrix metalloproteinase (MMP)-9 levels in the skin and its keratinocytes, activated MMP-9 impairs wound healing. Epigenetic regulation of DNA methylation status within promoter plays an important role alteration expression. Our aim was to investigate mechanism growth arrest damage-inducible 45a (GADD45a), a well-known demethylation regulatory protein that mediates methylation, In this study, we showed GADD45a markedly upregulated tissues from patients with diabetic foot...
Micheliolide (MCL) is a promising novel compound with broad-spectrum anticancer activity. However, little known regarding its action and mechanism in breast cancer. To explore the potential therapeutic application of MCL as chemosensitivity modulator, this study investigated effects on cisplatin sensitivity cancer underlying mechanisms. In 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide cytotoxicity assay xenograft tumor model, enhanced cell line MCF-7 both vitro vivo. Treatment...
Abstract: Dynamin-related protein 1 (Drp1) is a newly discovered therapeutic target for tumor initiation, migration, proliferation, and chemosensitivity. Thus, strategies that focus on targeting Drp1 its related signaling pathway pave new way to address the ineffectiveness of traditional cancer therapies. Micheliolide (MCL), guaianolide sesquiterpene lactone, can selectively eradicate acute myeloid leukemia stem or progenitor cells. But effect MCL mitochondrial dynamics cells still not well...
Abstract Chronic kidney disease (CKD) has been regarded as a risk for bone health. The aim of this study was to evaluate the effect CKD on defect repair in rats. Uremia induced by subtotal renal ablation and serum levels BUN PTH were significantly elevated four weeks after second surgery. Calvarial defects 5-mm diameter created implanted with or without deproteinized bovine mineral (DBBM). Micro-CT histological analyses consistently revealed decreased newly regenerated volume rats 4 8 weeks....
Scientific evidence has linked diabetes to a higher incidence and increased aggressiveness of breast cancer; however, mechanistic studies the numerous regulators involved in this process are insufficiently thorough. Advanced glycation end products (AGEs) play an important role chronic complications diabetes, but mechanisms AGEs cancer largely unexplored. In study, we first demonstrate that high AGE levels tissues associated with diabetic state poor patient outcomes. Furthermore, interact...
Abstract Naturally occurring isothiocyanates (ITCs) found in cruciferous vegetables, such as benzyl isothiocyanate (BITC), phenethyl (PEITC), and sulforaphane (SFN), have attracted significant research interest for their promising anti-cancer activity vitro vivo. While the induction of apoptosis is recognized to play a key role effects ITCs, specific protein targets associated upstream events underlying ITC-induced remain unknown. In this study, we present set chemical probes that are...
Objective: The purpose of this investigation was to examine the effect resorbable collagen plug (RCP) on bone regeneration in rat calvarial critical-size defects. Methods: About 5-mm-diameter defects were created forty 12-week-old male Sprague-Dawley rats and implanted with or without RCP. Animals killed at 1, 2, 4, 8 weeks postoperatively. After being killed, specimens collected subjected micro-computed tomography (μCT) histological analysis. Results: μCT showed a significant increase newly...
Abstract Background Metaplastic breast carcinoma (MBC) is a rare cancer subtype; most cases are triple‐negative cancers (TNBCs) and poorly responsive to conventional systemic therapy. Few potential diagnostic prognostic markers for distinguishing between metaplastic TNBC nonmetaplastic have been discovered. We performed bioinformatic analysis explore the underlying mechanism by which differs from provides pathogenic genes of TNBC. Methods Differentially expressed (DEGs) in tumors patients...
Histone deacetylase inhibitors (HDACis) are able to suppress breast cancer cells in vitro and vivo by altering the expression of estrogen receptor (ER), progesterone (PR) or human epidermal growth factor 2 (Her2/neu). Since HDACis can alter various microRNAs (miRNAs/miRs), present study aimed examine role miRNAs effects on cells. We first examined mRNA ER, PR, Her2/neu using RT-PCR protein levels western blot analysis MDA-MB-231 BT474 cells, after trichostatin A (TSA) vorinostat (SAHA)...
Abstract. Strict air pollution control strategies have been implemented in recent decades the North China Plain (NCP), previously one of most polluted regions world, and resulted considerable changes emissions pollutants. However, little is so far known about long-term trends regional background level NOx SO2, along with increase decrease processes emissions. In this study, seasonal diurnal variations SO2 as well their at a station NCP were characterized from 2004 to 2016. On average, mixing...