A5027605871- Advanced Surface Polishing Techniques
- Advanced machining processes and optimization
- Advanced Machining and Optimization Techniques
- Advanced Measurement and Metrology Techniques
- Optical Systems and Laser Technology
- RNA modifications and cancer
- Engineering Applied Research
- Laser Material Processing Techniques
- Cancer-related molecular mechanisms research
- Manufacturing Process and Optimization
- Laser and Thermal Forming Techniques
- Mesenchymal stem cell research
- Cancer-related gene regulation
- Tunneling and Rock Mechanics
- Immune cells in cancer
- Bone Tissue Engineering Materials
- Advanced optical system design
- MicroRNA in disease regulation
- Dental Implant Techniques and Outcomes
- Metallurgy and Material Forming
- Metal-Organic Frameworks: Synthesis and Applications
- Nuclear Physics and Applications
- Advancements in Photolithography Techniques
- Metal and Thin Film Mechanics
- Adaptive optics and wavefront sensing
University of Cambridge
2025
Wellcome Trust
2025
Xiamen University
2025
The Gurdon Institute
2025
Zhejiang University
2025
Sichuan University
2017-2024
State Key Laboratory of Oral Diseases
2017-2024
Gunma University
2012-2024
West China Hospital of Sichuan University
2024
Taiz University
2023
Abstract Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to dysfunction of marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) an essential intermediate tricarboxylic acid (TCA) cycle. Studies have revealed that αKG extends lifespan worms maintains pluripotency embryonic stem (ESCs). Here, we show administration increases mass aged mice, attenuates age-related loss, accelerates regeneration rodents....
Diabetes has long been considered a risk factor in implant therapy and impaired wound healing soft hard oral tissues. Magnesium proved to promote bone under normal conditions. Here, we elucidate the mechanism by which Mg
Abstract N6‐methyladenosine (m 6 A) modification, installed by METTL3‐METTL14 complex, is abundant and critical in eukaryotic mRNA. However, its role oral mucosal immunity remains ambiguous. Periodontitis a special but prevalent infectious disease characterized as hyperinflammation of mucosa bone resorption. Here, it reported that genetic deletion Mettl3 alleviates periodontal destruction via suppressing NLRP3 inflammasome activation. Mechanistically, the stability TNFAIP3 (also known A20)...
Alveolar type 2 (AT2) cells maintain lung health by acting as stem and producing pulmonary surfactant. AT2 dysfunction underlies many diseases, including interstitial disease (ILD), in which some inherited forms result from the mislocalization of surfactant protein C (SFTPC) variants. Lung modeling dissection underlying mechanisms remain challenging due to complexities deriving maintaining human ex vivo. Here, we describe development mature, expandable organoids derived fetal lungs are...
Abstract Alveolar bone is the thickened ridge of jaw that supports teeth. It subject to constant occlusal force and pathogens invasion, therefore under active remodeling immunomodulation. holds a distinct niche from long considering their different developmental origin postnatal pattern. However, systematic explanation alveolar at single-cell level still lacking. Here, we construct atlas mouse mandibular through RNA sequencing (scRNA-seq). A more immune microenvironment identified in bone,...
Periodontium supports teeth in a mechanically stimulated tissue environment, where heterogenous stem/progenitor populations contribute to periodontal homeostasis. In this study, Leptin receptor+ (Lepr+) cells are identified as distinct ligament stem cell (PDLSC) population by single-cell RNA sequencing and lineage tracing. These Lepr+ PDLSCs located the peri-vascular niche, possessing multilineage potential contributing repair response injury. Ablation of disrupts Hyper-loading unloading...
Abstract Positioning a diverse set of building blocks in well‐defined array enables cooperativity amongst them and the systematic programming functional properties. The extension this concept to porous metal–organic frameworks (MOFs) is challenging since installation multiple components well‐ordered framework requires careful design lattice topology, judicious selection blocks, precise control crystallization parameters. Herein, we report how met these challenges prepare first quinary MOF...
Abstract Chromodomain helicase DNA-binding protein 7 (CHD7), an ATP-dependent eukaryotic chromatin remodeling enzyme, is essential for the development of organs. The mutation CHD7 main cause CHARGE syndrome, but its function and mechanism in skeletal system remain unclear. Here, we show conditional knockout Chd7 bone marrow mesenchymal stem cells (MSCs) preosteoblasts leads to a pathological phenotype manifested as low mass severely high adiposity. Mechanistically, identify enhancement...
Trauma rapidly mobilizes the immune response of surrounding tissues and activates regeneration program. Manipulating to promote tissue shows a broad application prospect. However, understanding bone healing dynamics at cellular level remains limited. Here, we characterize landscape cells after alveolar injury reveal pivotal role infiltrating natural killer T (NKT) cells. We observe rapid increase in NKT injury, which inhibit osteogenic differentiation mesenchymal stem (MSCs) impair healing....
An injectable dual crosslinking hyaluronic acid hydrogel was prepared by a thiol–ene click reaction and conversion between sulfhydryl disulfide bonds. This exhibits good biocompatibility potential biomedical applications.
Recombinant humanized type III collagen (rhCol III) is a highly adhesive biomaterial composed of 16 adhesion-related tandem repeats refined from human collagen. Here, we aimed to investigate the effect rhCol on oral ulcers and reveal underlying mechanism.
Introduction Hepatic fibrosis (HF), a progressive chronic liver disease, is serious threat to global public health. The lack of preventive and therapeutic strategies has created an urgent need for effective anti-fibrosis agents. There growing evidence that natural products might provide safe interventions HF. Among them, rhaponticin (RHA), stilbenoid glucoside product isolated from medicinal plants Rheum L. Polygonaceae Juss. many pharmacological activities such as anti-inflammatory,...
Cotranslational folding of nascent polypeptides is essential for protein function and cellular homeostasis. Ribosome-associated chaperones assist in this process, but coordination between their recruitment translation initiation remains poorly understood. We report here that specific binding sites eukaryotic factor eIF3 within the 5′ untranslated regions (5′UTRs) mRNAs promote its retention on 80S ribosomes during synthesis select endoplasmic reticulum (ER) membrane proteins. Disruption...
Bone tissue is intrinsically electroactive, and electrical signaling one of its key regulatory mechanisms. The electroactive poly (vinylidene fluoride trifluoroethylene) (PVTF), due to piezoelectricity, can provide stimulation cells, regulating their proliferation osteogenic differentiation. Collagen I (COL) the main organic component bone involved in various physiological processes bone. A crucial question that remains be explored whether materials meet requirements for GBR membranes what...
Mechanical signals have been played close attention to regulate chondrogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). In this study, dynamic mechanical loading simulation with natural frequencies and intensities were applied the 3D cultured BMSCs–collagen scaffold constructs. We investigated effects on cell adhesion, uniform distribution, proliferation, secretion extracellular matrix (ECM) The results indicated that facilitated BMSCs proliferation ECM a slight...
We present the design, fabrication, and evaluation of a large total-reflection mirror for focusing x-ray free-electron laser beams to nanometer dimensions. used an elliptical made silicon that was 400 mm long had focal length 550 mm. Electrolytic in-process dressing grinding initial-step figuring elastic emission machining employed final surface smoothing. A figure accuracy with peak-to-valley height 2 nm achieved across entire area. Characterization focused beam performed at BL29XUL...
Abstract Genetic variation is considered to affect the N 6 ‐methyladenosine (m6A) RNA transcript modification, which most prevalent posttranscriptional messenger modification. This study aimed identify m6A‐associated single‐nucleotide polymorphisms (m6A‐SNPs) that may m6A methylation from numerous periodontitis (PD) SNPs. We identified an abundance of m6A‐SNPs by analyzing raw data published PD genome‐wide association studies and list m6AVar database. Other evidence was found in public...
Oncostatin M (OSM) has been reported to be a key regulating factor in the process of tumor development. Previous studies have demonstrated both promotion and inhibition effects OSM tumors, therefore inspiring controversies. However, no systematic assessment across various cancers is available, mechanisms behind OSM-related cancer progression remain elucidated.Based on The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) databases, we conducted pan-cancer analysis explore its...
As the largest salivary gland in oral cavity, parotid plays an important role initial digesting and lubricating food. The abnormal secretory function of can lead to dental caries mucosal inflammation. In recent years, single-cell RNA sequencing (scRNA-seq) has been used explore heterogeneity diversity cells various organs tissues. However, transcription profile human at resolution not reported yet. this study, we constructed cell atlas using 10× Genomics platform. Characteristic gene...