A5103023144- Dental Implant Techniques and Outcomes
- Bone Tissue Engineering Materials
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Periodontal Regeneration and Treatments
- Cancer-related Molecular Pathways
- Dental materials and restorations
- RNA Interference and Gene Delivery
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- Peroxisome Proliferator-Activated Receptors
- DNA Repair Mechanisms
- Bioactive natural compounds
- Endodontics and Root Canal Treatments
- Nasal Surgery and Airway Studies
- Hydrogels: synthesis, properties, applications
- Nuclear Structure and Function
- Dental Radiography and Imaging
- Histone Deacetylase Inhibitors Research
- Hepatitis Viruses Studies and Epidemiology
- Cancer, Hypoxia, and Metabolism
- Liver physiology and pathology
State Key Laboratory of Oral Diseases
2013-2023
Peking University
2019-2023
Sichuan University
2006-2023
Augusta University
2008-2015
Jinan University
2012-2015
Georgia Regents Medical Center
2015
West China Medical Center of Sichuan University
2000
Abstract Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to dysfunction of marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) an essential intermediate tricarboxylic acid (TCA) cycle. Studies have revealed that αKG extends lifespan worms maintains pluripotency embryonic stem (ESCs). Here, we show administration increases mass aged mice, attenuates age-related loss, accelerates regeneration rodents....
Abstract Age-dependent bone loss has been well documented in both human and animal models. Although the underlying causal mechanisms are probably multifactorial, it hypothesized that alterations progenitor cell number or function important. Little is known regarding properties of marrow stromal cells (BMSCs) during aging process, so question whether alters BMSC/progenitor osteogenic differentiation remains unanswered. In this study, we examined age-dependent changes potential between mature...
In orthopedics, the regeneration and repair of cartilage or bone defects after trauma, cancer, metabolic disorders is still a major clinical challenge. Through developmental plasticity, marrow mesenchymal stem cells (BMSSCs) are important seed for musculoskeletal tissue engineering approach. The present study sought to determine ectopic osteogenic chondrogenic ability BMSSCs in combination with scaffolding material made from alginate gel. After isolation BALB/C mice, were expanded vitro...
Anemone flaccida Fr . Schmidt (Ranunculaceae) (Di Wu in Chinese) is used to treat punch injury and rheumatoid arthritis (RA). However, the active compounds underlying mechanism of action mediating anti-arthritic effects A. remain unclear. This study aims evaluate crude triterpenoid saponins (AFS) on RA using a type II collagen (CII)-induced (CIA) rat model, assess anti-inflammatory main AFS, namely flaccidoside II, anhuienoside E, glycoside St-I4a, hemsgiganoside B, hederasaponin...
Extracellular matrix (ECM), like biomimetic surface modification of titanium implants, is a promising method for improving its biocompatibility. In this paper chitosan (Chi) and heparin (Hep) multilayer was coated on pure using layer-by-layer (LbL) self-assembly technique. The Hep-Chi growth carried out by first depositing single layer positively charged poly-L-lysine (PLL) the NaOH-treated substrate (negatively surface), followed alternate deposition negatively Hep Chi, terminated an...
Concentrated growth factors (CGFs) are widely used in surgery with bone grafting, but the release of from CGFs is rapid. RADA16, a self-assembling peptide, can form scaffold that similar to extracellular matrix. Based on properties RADA16 and CGF, we hypothesized nanofiber hydrogel could enhance function hydrogel-wrapped (RADA16-CGFs) would perform good osteoinductive function. This study aimed investigate RADA16-CGFs. Scanning electron microscopy, rheometry, ELISA were performed, MC3T3-E1...
Genetic variability has significant impacts on biological characteristics and pathogenicity of hepatitis B virus (HBV), in which the N-terminal sequence presurface 1 (preS1) region HBV large surface protein (LHBs) displays genotype (GT) dependent genetic heterogeneity. However, influence this heterogeneity its roles is largely unknown. By analyzing 6560 full-length genome sequences GTA-GTH downloaded from HBVdb database, preS1 were divided into four representative types, namely C-type...
Background and Objective Nowadays, most designs for the transmucosal surface of implants are machined‐smooth. However, connective tissue adhered to smooth an implant has poor mechanical resistance, which can render separation from interface induce epithelial downgrowth. Modification implants, help form a good seal tissue, is therefore desired. We hypothesized that anodic oxidation ( AO ) polydopamine PD deposition could be used enhance attachment between peri‐implant tissue. tested this...
Abstract To simulate extra‐cellular matrix, a novel three‐dimensional scaffold of polyelectrolyte complex (PEC) hydrogel as an osteoblast carrier was synthesized. First, chitosan, natural glycosaminoglycan, modified by phosphorylation to obtain water‐soluble phosphorylated chitosan ( P ‐content: 10.7 mass%). The PEC then formed from equal volumes 0.173 mass% in water and 1 1% (V/V) acetic acid solution. Rat osteoblasts were seeded the hydrogel. had hierarchically‐porous structure good...
Three-dimensionally printed polyetheretherketone (PEEK) materials are promising for fabricating customized dental abutments. This study aimed to investigate the adhesive property of a 3D-printed PEEK material. The effects surface treatment and temporary crown on shear bond strength were evaluated. A total 108 discs 3D by fused-filament fabrication. Surface treatments, including sandblasting, abrasive paper grinding, CO2 laser ablation, applied discs, with untreated specimens set as control....
Cellular fibronectin (cFn) is a type of bioactive non-collagen glycoprotein regarded as the main substance used to maintain periodontal attachment. The content cFn in some specific sites can reflect progress periodontitis or peri-implantitis. This study aims evaluate expression messenger RNA (mRNA) tissues adult and peri-implantitis by real-time fluorescent quantitative polymerase chain reaction (PCR) determine its clinical significance. A total 30 patients were divided into three groups 10:...
This study aims to find an optimal method for modifying the neck of dental implants gingival attachment through in vitro investigations biological features various anodised TiO2 films. The titanium sheets were divided into four groups: a control group and three test groups classified according anodisation voltage (Group 150 V, Group 180 V or 200 V).The surface microstructure crystal structure observed using scanning electron microscopy X-ray diffraction. protein adsorption ability,...
The existence of hepatic cancer stem cells (CSCs) contributes to chemotherapy resistance and recurrence after treatment or surgery. However, very little is known about the hepatitis B virus (HBV) replication its relationship with stemness hepatocellular carcinoma (HCC) in HBV-related HCC patients. We collected tumor tissues (T), matched adjacent non-tumor (NT), distal (FNT) from 55 patients for analysis. found HBV DNA levels were higher T samples than NT FNT samples, but pgRNA total RNA...
How the ataxia telangiectasia mutated (ATM) protein kinase, a core in DNA damage response, is regulated at post-transcription level remains unclear. Here it identified that Reprimo (RPRM) downregulates ATM levels, resulting impaired repair and enhanced cellular radiosensitivity. Mechanistically, although primarily localized cytoplasm, RPRM translocates to nucleus shortly after induced by X-irradiation, interacts with promotes its nuclear export proteasomal degradation. The translocation...
Hepatitis B virus (HBV) infection contributes to hepatocellular carcinoma (HCC) tumorigenesis, drug resistance, and recurrence, although the underlying molecular mechanisms remain unclear. Recent studies suggest that HBV may be associated with liver cancer stem cells (LCSCs), but exact are yet resolved. In this study, we aimed analyze role of in regulating stemness HCCs, which is closely linked resistance. Sphere formation assay real-time Polymerase Chain Reaction quantification were used...