Lei Wang

ORCID: 0000-0003-0778-2175
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Research Areas
  • Hepatitis B Virus Studies
  • Hepatitis C virus research
  • Liver Disease Diagnosis and Treatment
  • Traditional Chinese Medicine Studies
  • Diabetes Management and Education
  • Healthcare Systems and Public Health
  • Surgical site infection prevention
  • Viral Infectious Diseases and Gene Expression in Insects
  • Immunotherapy and Immune Responses
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Gastric Cancer Management and Outcomes
  • HIV/AIDS drug development and treatment
  • Mobile Health and mHealth Applications
  • Health Literacy and Information Accessibility
  • Pancreatic and Hepatic Oncology Research
  • Pelvic and Acetabular Injuries
  • Monoclonal and Polyclonal Antibodies Research
  • Liver Disease and Transplantation
  • Biochemical and Molecular Research
  • Cholangiocarcinoma and Gallbladder Cancer Studies
  • Hepatitis Viruses Studies and Epidemiology
  • Reconstructive Surgery and Microvascular Techniques

Peking University
2021

Fudan University
2020

Shanghai University of Traditional Chinese Medicine
2020

Chongqing Medical University
2017

First Affiliated Hospital of Xinxiang Medical University
2013

Tianjin Infectious Diseases Hospital
2007

Tianjin University of Science and Technology
2006

This paper reports the synthesis of five sulfonamide derivatives, production broad-specificity polyclonal antibodies for immunoassay sulfonamides, and analysis milk samples by developed assay. The three-step procedure reported in most literature was adopted modified this study. In procedure, purification intermediate avoided time shortened from >20 to 6−9 h with improved yields. method is generally applicable haptens containing common structure sulfonamides. Three were coupled keyhole limpet...

10.1021/jf060868u article EN Journal of Agricultural and Food Chemistry 2006-06-01

Genetic variability has significant impacts on biological characteristics and pathogenicity of hepatitis B virus (HBV), in which the N-terminal sequence presurface 1 (preS1) region HBV large surface protein (LHBs) displays genotype (GT) dependent genetic heterogeneity. However, influence this heterogeneity its roles is largely unknown. By analyzing 6560 full-length genome sequences GTA-GTH downloaded from HBVdb database, preS1 were divided into four representative types, namely C-type...

10.3389/fmicb.2021.687785 article EN cc-by Frontiers in Microbiology 2021-07-09

Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection remains a major health problem. HBV e antigen (HBeAg)-negative strains have become prevalent. Previously, no animal model mimicked clinical course HBeAg-negative infection. To establish model, 3.2-kb full-length genome was cloned from sample and then circularized to form covalently closed circular (cccDNA). The resulting cccDNA introduced into liver C57BL/6J mice through hydrodynamic injection. Persistence...

10.1371/journal.pone.0175992 article EN cc-by PLoS ONE 2017-04-20

Patients with diabetes in China have low health literacy, which likely leads to poor clinical outcomes. This study aimed assess the effectiveness of literacy and exercise interventions on measurements Chinese adults type 2 mellitus (T2DM).

10.1136/bmjdrc-2020-001179 article EN cc-by-nc BMJ Open Diabetes Research & Care 2020-06-01

Objective To assess the application value of pancreatic stent placement for endoscopic resection duodenal major papilla adenoma. Methods A total 67 cases adenoma that were confirmed by biopsy and underwent papillectomy from August 2007 to July 2016 in endoscopy center Drum Tower Hospital Nanjing analyzed retrospectively. There 50 patients treated with 17 without as control group. The general information, efficacy complications two groups collected at same time. Results There no...

10.3760/cma.j.issn.1007-5232.2017.06.011 article EN Zhonghua xiaohua neijing zazhi 2017-06-20

Abstract Background: Plasmacytoid dendritic cell (pDC) has been reported showing obvious maturation and deficient function in chronic hepatitis B (CHB) patients. One of the traditional Chinese medicine, Bushen Jianpi Recipe (BSJPR), efficacy suppressing HBV by improving immune system. In this study, we explained its mechanism on cellular level.Methods: We measured contents pDC maturation-related extracellular cytokines intracellular signaling pathway proteins HBV-infected or not infected...

10.21203/rs.3.rs-124433/v1 preprint EN cc-by Research Square (Research Square) 2020-12-11
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