A5101552914- Ocular Diseases and Behçet’s Syndrome
- Hepatitis B Virus Studies
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Hepatitis C virus research
- Asthma and respiratory diseases
- RNA modifications and cancer
- Otitis Media and Relapsing Polychondritis
- Food Allergy and Anaphylaxis Research
- Acute Lymphoblastic Leukemia research
- interferon and immune responses
- Liver Disease Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Inflammasome and immune disorders
- Metabolomics and Mass Spectrometry Studies
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Ocular Oncology and Treatments
- Cardiac Health and Mental Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Spondyloarthritis Studies and Treatments
Guangzhou Medical University
2024-2025
Chongqing Medical University
2011-2024
Children's Hospital of Chongqing Medical University
2024
Sichuan Agricultural University
2022
Huzhou University
2022
Hunan Provincial People's Hospital
2022
The Affiliated Yongchuan Hospital of Chongqing Medical University
2011-2021
Affiliated Hospital of Southwest Medical University
2021
Macau University of Science and Technology
2021
Wuxi People's Hospital
2018
TLR2, TLR4, TLR8, and TLR9 have been reported to be associated with several autoimmune diseases. The current study aimed explore whether singe nucleotide polymorphisms (SNPs) of these four genes were ocular Behçet's disease (BD), Vogt-Koyanagi-Harada (VKH) syndrome, acute anterior uveitis (AAU) or without ankylosing spondylitis (AS), pediatric in Han Chinese.Genotyping was performed by PCR-restriction fragment length polymorphism. first stage comprised 400 BD patients, VKH syndrome AAU ± AS...
TNF Receptor-Associated Factor 5 (TRAF5) has been shown to be associated with autoimmune disease. The current study sought investigate the potential association of TRAF5 acute anterior uveitis (AAU) and pediatric in Han Chinese.Three SNPs were analyzed 450 AAU patients or without ankylosing spondylitis (AS), 458 patients, 1,601 healthy controls by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) TaqMan SNP Genotyping Assay. Numerous variables evaluated,...
Abstract The inactivation of tumor-suppressor genes contributes heavily to oncogenesis. mutation TP53 has been well-studied and recognized as a major factor in the development tumors. Yet other means p53 not well-elucidated. We previously identified hypermethylated gene ZDHHC1 that suppresses tumor growth when expression was restored, but specific mechanism yet be found. protein product is an S-palmitoyltransferase we have substrate for ZDHHC1-mediated palmitoylation, specifically at C135,...
Abstract Background Among the common preventable cancers of women, cervical cancer has highest morbidity. It is curable if detected at an early stage. However, reliable diagnostic and prognostic markers, which relate to physiologic pathologic regulation cancer, are not available. In this study, one such potential marker, ZBTB28, was evaluated for its usefulness in assessment. Methods Public database analysis, reverse-transcription polymerase chain reaction (PCR), methylation-specific PCR...
Background TRAF5 and TRAF3IP2 have been reported to be associated with several autoimmune diseases. Behçet's disease (BD) Vogt-Koyanagi-Harada (VKH) syndrome are two uveitis entities whereby both genetic environmental factors thought involved. Objective The role of in BD VKH has not yet was therefore the subject this study. Methods study included 789 patients, 940 patients 1601 healthy unrelated individuals. Genotyping performed by polymerase chain reaction-restriction fragment length...
Background Recent reports show that gene therapy may provide a long-term, safe and effective intervention for human diseases. In this study, we investigated the effectiveness of adeno-associated virus 2 (AAV2) based interferon-alpha (hIFN-α) in experimental autoimmune uveoretinitis (EAU), classic model uveitis. Methodology/Principal Findings An AAV2 vector harboring hIFN-α (AAV2.hIFN-α) was subretinally injected into B10RIII mice at two doses (1.5×106 vg, 1.5×108 vg). encoding green...
Rhizoma Atractylodis macrocephalae have an important role in treating cerebrovascular diseases Traditional Chinese Medicine (TCM). The purpose of the present study was to determine neuroprotective effect macrocephalaon polysaccharides (AMPS) on hypoxia‑induced apoptosis cerebral cortical neurons. Neuronal cells obtained from neonatal rats were divided into following groups: Normal control (group C); positive induced by hypoxia‑reoxygenation culture rat primary neurons A); treated with 0.025...
This study aims to determine whether the combined blockade of IL-1β and TNF-α can alleviate pathological allergic inflammatory reaction in nasal mucosa lung tissues rhinitis (AR) guinea pigs. Healthy pigs treated with saline were used as healthy controls. The AR randomly divided into (1) model group intranasal saline; (2) 0.1% nonspecific IgY treatment group; (3) anti-TNF-α (4) anti-IL-1β (5) (6) fluticasone propionate group. cells evaluated using Wright's staining. Histopathology was...
Hepatocellular carcinoma (HCC) is a highly vascularized, inflammatory, and abnormally proliferating tumor. Monotherapy often unable to effectively comprehensively inhibit the progress of HCC. In present study, we selected ginsenoside Rg3, ganoderma lucidum polysaccharide (GLP), oridonin as combined therapy. These three plant monomers play important roles in anti-angiogenesis, immunological activation, apoptosis promotion, respectively. However, low solubility poor bioavailability seriously...
Purpose.: Janus kinase 1 (JAK1), JAK2, and signal transducer activator of transcription 3 (STAT3) play an important role in Th1 Th17 differentiation gene polymorphisms these factors have been demonstrated to be associated with certain autoimmune diseases. The present study was performed assess the association between JAK1, STAT3 Vogt–Koyanagi–Harada (VKH) syndrome a HanChinese population. Methods.: A case-control 737 Chinese VKH patients 809 healthy controls from Han genotypes three...
Abstract Background and Aim Hepatocellular carcinoma (HCC) urgently needs a marker for early diagnosis targeted treatment. C2orf40 has been identified as tumor suppressor gene in many cancers. However, the precise role regulatory mechanism by contribute to HCC remain elusive merit exploration. Methods Reverse‐transcription PCR, quantitative real‐time methylation‐specific PCR were used detect expression methylation of cell lines or tissues. The effects liver cancer cells examined via colony...
Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection remains a major health problem. HBV e antigen (HBeAg)-negative strains have become prevalent. Previously, no animal model mimicked clinical course HBeAg-negative infection. To establish model, 3.2-kb full-length genome was cloned from sample and then circularized to form covalently closed circular (cccDNA). The resulting cccDNA introduced into liver C57BL/6J mice through hydrodynamic injection. Persistence...
Rhizoma Dioscoreae polysaccharides (RDPS) are the primary active ingredient of Dioscoreae, which is a traditional Chinese medicine. RDPS have previously been shown to scavenge reactive oxygen species, and protect against D-galactose-induced mimetic aging. The present study aimed investigate neuroprotective effects hypoxia-induced neuronal cell apoptosis. Neuronal cells harvested from pregnant Sprague-Dawley rats were divided into groups, as follows: i) Normal control group; ii) apoptosis...
High replication and mutation rates of hepatitis B virus (HBV) often lead to reduced or suppressed e antigen expression. The most common mutations are genomic variations in the basal core promoter (BCP) pre-core (PC) regions. However, effect BCP/PC on HBV phenotype vivo remains unclear. We compared analyzed reverse mouse models. In addition terminating expression HBeAg, also resulted a significant decrease HBsAg, DNA, cccDNA early stage, an obvious increase serum alanine aminotransferase...
Abstract Uveal melanoma (UM) is the most common primary ocular malignancy in adults, and 5‐year disease‐related mortality rate 30%. MAL proteolipid family (MALs), including T‐cell differentiation protein (MAL), 2 (MAL2), like (MALL), were involved progression prognosis of many different cancers. However, role MALs UM was not reported. samples extracted from The Cancer Genome Atlas. R software (R3.6.3) used to comprehensively analyze roles (significance threshold: p < 0.05). mRNA expression...
Abstract Kinetochore-localized astrin/SPAG5-binding protein (KNSTRN) promotes the progression of bladder cancer and lung adenocarcinoma. However, its expression biological function in breast remain largely unknown. Therefore, this study aimed to analyze KNSTRN expression, prognoses, correlation with immune infiltration, expression-associated genes, regulated signaling pathways characterize role regulating cell cycle using both bioinformatics vitro functional experiments. Analyses The Cancer...
Follicle-stimulating hormone (FSH) regulates oogenesis and spermatogenesis by binding to its receptor (FSHR) on target cells in the ovary testis, respectively. The signaling cascades activated after ligand are extremely complex have been shown include protein kinase A phosphatidylinositol 3-kinase/protein kinase. adapter APPL1 (adapter with PH domain, PTB leucine zipper), which is an assortment of other proteins, was previously identified interact FSH B (AKT) pathway. plays important role...