A5036936453- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Otitis Media and Relapsing Polychondritis
- interferon and immune responses
- Inflammasome and immune disorders
- Cytomegalovirus and herpesvirus research
- RNA modifications and cancer
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Autoimmune and Inflammatory Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinal Diseases and Treatments
- MicroRNA in disease regulation
- Autoimmune and Inflammatory Disorders
- Immunodeficiency and Autoimmune Disorders
- Retinal and Optic Conditions
- Retinal Development and Disorders
- Peroxisome Proliferator-Activated Receptors
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immunotherapy and Immune Responses
- Retinopathy of Prematurity Studies
- Connexins and lens biology
- Spondyloarthritis Studies and Treatments
- Single-cell and spatial transcriptomics
- Adenosine and Purinergic Signaling
Capital Medical University
2023-2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2016-2025
Chongqing Medical University
2016-2025
Beijing Tongren Hospital
2023-2025
Tianjin Institute of Industrial Biotechnology
2025
Chinese Academy of Sciences
2025
University of Chinese Academy of Sciences
2025
Yunnan Metallurgical Group (China)
2025
Kunming University of Science and Technology
2023-2025
National Laboratory of Energy and Geology
2025
Behcet's disease (BD) is a recalcitrant, multisystemic inflammatory that can lead to irreversible blindness. Microbial agents have been considered contribute the pathogenesis of this disease, but underlying mechanisms remain unclear. In study, we investigated association gut microbiome composition with BD as well its possible roles in development disease. Fecal and saliva samples were collected from 32 active patients 74 healthy controls. DNA extracted fecal was subjected metagenomic...
Abstract Background Ocular neovascularization is a leading cause of blindness. Retinal microglia have been implicated in hypoxia-induced angiogenesis and vasculopathy, but the underlying mechanisms are not entirely clear. Lactylation novel lactate-derived posttranslational modification that plays key roles multiple cellular processes. Since hypoxia ischemic retinopathy precipitating factor for retinal neovascularization, lactylation very likely to be involved this process. The present study...
Galectin-3, an attractive molecule of innate immunity, has been reported to be involved in the neuroinflammatory diseases. However, role Galectin-3 autoimmune uveitis is still unclear. The purpose this study was investigate effect and mechanism on microglial activation inflammation experimental (EAU). We immunized female C57BL/6 J mice with IRBP651-670 induce EAU specific inhibitor intravitreally injected mice. Disease severity evaluated by clinical histopathological scores....
Uveitis causes blindness and critical visual impairment in people of all ages, retinal microglia participate uveitis progression. Unfortunately, effective treatment is deficient. Icariin (ICA) a bioactive monomer derived from Epimedium. However, the role ICA remains elusive. Our study indicated that alleviated intraocular inflammation vivo. Further results showed proinflammatory M1 could be transferred to anti-inflammatory M2 by retina HMC3 cells. direct pharmacological target unknown, this...
Abstract Activated microglia in the retina are essential for development of autoimmune uveitis. Yin‐Yang 1 (YY1) is an important transcription factor that participates multiple inflammatory and immune‐mediated diseases. Here, increased YY1 lactylation retinal within experimental uveitis (EAU) group observed. contributed to boosting microglial activation promoting their proliferation migration abilities. Inhibition suppressed attenuated inflammation EAU. Mechanistically, cleavage under...
Vascular endothelial growth factor (VEGF) is one of the most powerful proangiogenic factors and plays an important role in multiple diseases. Increased glycolytic rates lactate accumulation are associated with pathological angiogenesis.
To identify susceptibility loci for Behçet's disease (BD) and elucidate their functional role.A genome-wide association study (GWAS) studies were conducted. A total of 149 patients 951 controls enrolled in the initial GWAS, 554 1,159 replication study. Real-time polymerase chain reaction, luciferase reporter assay, enzyme-linked immunosorbent assay performed.Our GWAS identified a locus around STAT4 (single-nucleotide polymorphisms [SNPs] rs7574070, rs7572482, rs897200; P = 3.36 × 10(-7) to...
Dysregulation of CD4+ T cell differentiation is linked to autoimmune diseases. Metabolic reprogramming from oxidative phosphorylation glycolysis and accumulation lactate are involved in this process. However, the underlying mechanisms remain unclear. Our study showed that lactate-derived lactylation regulated differentiation. Lactylation levels cells increased with progression experimental uveitis (EAU). Inhibition suppressed TH17 attenuated EAU inflammation. The global lactylome revealed...
<h3>Purpose</h3> IL-23 has been shown to be involved in the pathogenesis of Behcet9s disease (BD) through promoting IL-17 production. This study examined whether <i>IL-23R</i> polymorphisms were associated with susceptibility this a Chinese Han population. <h3>Methods</h3> Four single-nucleotide (SNP), rs7517847, rs11209032, rs 1343151 and rs17375018 genotyped 338 BD patients 407 age, sex ethnically matched healthy controls using PCR restriction fragment length polymorphism assay....
MicroRNA-146a (miR-146a) is involved in certain immune-mediated diseases. Transcription factor Ets-1 strongly affects miR-146a promoter activity and directly regulates expression. This study was performed to investigate the association of gene polymorphisms with Behçet's disease (BD) Vogt-Koyanagi-Harada (VKH) a Chinese Han population.A total 809 patients BD, 613 VKH 1132 normal controls were genotyped for miR-146a/rs2910164, rs57095329 rs6864584, Ets-1/rs1128334 rs10893872 using PCR...
Uveitis is characterized as a common cause of blindness worldwide. Aryl hydrocarbon receptor (AhR), ligand-activated nuclear receptor, has been implicated to play role in human uveitis, although the exact mechanisms remain poorly understood. The purpose this study was enhance our knowledge concerning AhR during intraocular inflammation. We immunized wild type and knockout C57BL/6J mice with IRBP651-670 induce experimental autoimmune uveitis (EAU). Disease severity evaluated both clinical...
Purpose: Apigenin is a natural small molecule compound widely present in various vegetables and fruits. Recently, was reported to inhibit lipopolysaccharide (LPS)-simulated microglial proinflammatory activation. Considering the important role of microglia retinal disorders, we wonder whether could exert therapeutic effect on experimental autoimmune uveitis (EAU) through reprogramming beneficial subtype. Methods: EAU induced C57BL/6J mice by immunization with interphotoreceptor...
Abstract Autoimmune uveitis (AU) is a kind of immune‐mediated disease resulting in irreversible ocular damage and even permanent vision loss. However, the precise mechanism underlying dynamic immune changes contributing to initiation progression AU remains unclear. Here, we induced an experimental (EAU) model with IRBP 651‐670 found that day[D]14 was inflammatory summit remarking clinical histopathological manifestations activation retinal microglia exhibited time‐dependent pattern EAU...
Th17 cells, a lymphocyte subpopulation that is characterized by the expression of transcription factor "retinoic acid receptor-related orphan receptor gamma-t" (RORγt), plays an important role in pathogenesis autoimmune disease. The current study was set up to discover novel and non-steroidal small-molecule inverse agonists RORγt determine their effects on Structure-based virtual screening (SBVS) used find compounds targeting RORγt. Flow cytometry detect cell differentiation. Inverse were...
The NLRP3 inflammasome has been shown to be involved in the development of uveitis, but exact mechanism remains elusive. This study was undertaken explore role uveitis.First, Nlrp3-deficient mice were used experimental autoimmune diseases, such as uveitis (EAU) and encephalomyelitis (EAE). Next, gathering ASC, activation caspase 1 gasdermin D, secretion lactate dehydrogenase interleukin-1β detected confirm macrophage pyroptosis AIM2 Nlrp3-/- mice. Additionally, RNA sequencing chromatin...
Vogt-Koyanagi-Harada (VKH) disease is a leading cause of blindness in young and middle-aged people. However, the etiology VKH remains unclear. Here, we performed first trio-based whole-exome sequencing study, which enrolled 25 patients 50 controls, followed by study 2081 from Han Chinese population to uncover detrimental mutations. A total 15 de novo mutations were identified, with one most important being membrane palmitoylated protein 2 (MPP2) p.K315N (MPP2-N315) mutation. The MPP2-N315...