A5009216477- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neonatal and fetal brain pathology
- Cholinesterase and Neurodegenerative Diseases
- Anesthesia and Neurotoxicity Research
- Genetics and Neurodevelopmental Disorders
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Inflammasome and immune disorders
- Photoreceptor and optogenetics research
- Neurogenesis and neuroplasticity mechanisms
- Nuclear Receptors and Signaling
- Receptor Mechanisms and Signaling
- Autism Spectrum Disorder Research
- Nerve injury and regeneration
- Neural dynamics and brain function
- Microtubule and mitosis dynamics
- Pain Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Adenosine and Purinergic Signaling
- Nicotinic Acetylcholine Receptors Study
Children's Hospital of Chongqing Medical University
2016-2025
Chongqing Medical University
2016-2025
China International Science and Technology Cooperation
2012-2023
Ministry of Education of the People's Republic of China
2014
University of British Columbia
2010-2013
Chinese Academy of Sciences
2004-2009
Kunming Institute of Zoology
2004-2009
Although NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) and depression (LTD) of glutamatergic transmission are candidate mechanisms for spatial memory, the precise contributions LTP LTD remain poorly understood. Here, we report that in hippocampal CA1 region freely moving adult rats were prevented by NMDAR 2A (GluN2A) 2B subunit (GluN2B) preferential antagonists, respectively. These results strongly suggest subtype antagonists appropriate tools to probe roles memory. Using a...
Posttranslational modification (PTM) of the amyloid precursor protein (APP) plays a critical role in Alzheimer's disease (AD). Recent evidence reveals that lactylation modification, as novel PTM, is implicated occurrence and development AD. However, whether how APP contributes to both pathogenesis cognitive function AD remains unknown. Here, we observed reduction patients model mice cells. Proteomic mass spectrometry analysis further identified lysine 612 (APP-K612la) crucial site for...
Long-term potentiation (LTP) of synaptic strength between hippocampal neurons is associated with learning and memory, LTP dysfunction thought to underlie memory loss. can be temporally mechanistically classified into decaying (early-phase) nondecaying (late-phase) LTP. While the nature depend on protein synthesis contribute maintenance, little known about mechanisms roles Here, we demonstrated that inhibiting endocytosis postsynaptic α-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid...
Abstract Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is an essential negative regulator of MAPKs by dephosphorylating at both tyrosine and threonine residues. Dysregulation the MAPK signaling pathway has been associated with Alzheimer’s disease (AD). However, role MKP-1 in AD pathogenesis remains elusive. Here, we report that levels were decreased brain tissues patients mouse model. The reduction gene expression appeared to be a result transcriptional inhibition via...
Abstract Alzheimer's disease (AD) is one of the most common causes neurodegenerative diseases in elderly. The accumulation amyloid‐β (Aβ) peptides pathological hallmarks AD and leads to impairments synaptic plasticity cognitive function. transient receptor potential vanilloid 1 (TRPV1), a nonselective cation channel, involved memory. However, role TRPV1 pathogenesis remains largely elusive. Here, we reported that expression was decreased brain APP23/PS45 double transgenic model mice. Genetic...
It is well known that novel environments can enhance learning and memory. However, the underlying mechanisms remain poorly understood. Here, we report that, in freely moving rats, novelty exploration facilitates production of hippocampal CA1 long-term depression (LTD), a characterized form synaptic plasticity believed to be cellular substrate spatial learning, thereby converts short-term memory (STM) into (LTM) an inhibitory avoidance procedure. Blocking induction or expression LTD with two...
Stroke is the leading cause of disability in developed countries. However, no treatment available beyond 3 h post-ictus. Here, we report that nuclear translocation PTEN (phosphatase and tensin homolog deleted on chromosome TEN) a delayed step causatively to excitotoxic ( vitro ) ischemic vivo neuronal injuries. We found stimulation N -methyl- d -aspartate (NMDA) resulted cultured neurons, process requiring mono-ubiquitination at lysine 13 residue (K13), as was prevented by mutation K13 or...
Maternal sleep deprivation (MSD) is a global public health problem that affects the physical and mental development of pregnant women their newborns. The latest research suggests (SD) disrupts gut microbiota, leading to neuroinflammation psychological disturbances. However, it unclear whether MSD establishment microbiota in In present study, was performed on Sprague-Dawley rats third trimester pregnancy (gestational days 15–21), after which intestinal contents brain tissues were collected...
Summary Background Parkinson disease ( PD ) is a neurodegenerative characterized by the loss of dopaminergic neurons in substantia nigra SN and diminished dopamine content striatum, which at least partly associated with α ‐synuclein protein overexpression these neurons. Recent reports show that 7,8‐dihydroxyflavone DHF ), TrkB agonist, has beneficial effects animal model . However, it unclear whether therapeutic are expression ‐synuclein. Aims In this study, we investigated protective on...
Sleep deprivation during pregnancy is a serious public health problem as it can affect the of pregnant women and newborns. However, not well studied whether sleep at different stages has similar effects on emotional cognitive functions offspring, if so, potential cellular mechanisms also remain poorly understood. In present study, rats were subjected to for 6 h per day by gentle handling first (gestational days 1–7), second 8–14) third trimester 15–21) pregnancy, respectively. The...
Alzheimer's disease (AD) is a chronic neurodegenerative leading to dementia, which characterized by progressive memory loss and other cognitive dysfunctions. Recent studies have attested that noninvasive repetitive transcranial magnetic stimulation (rTMS) may help improve function in patients with AD. However, the majority of these focused on effects high-frequency rTMS function, little known about low-frequency AD treatment. Furthermore, potential mechanisms improvement learning also remain...
Neonatal hypoxia-ischemia is one of the main reasons that cause neuronal damage and neonatal death. Several studies have shown tanshinone I (TsI), major ingredients Danshen, exerts potential neuroprotective effect in adult mice exposed to permanent left cerebral ischemia. However, it unclear whether administration TsI has on hypoxic-ischemic brain (HIBD), if so, mechanisms also remain unclear. Here, we reported treatment with (5 mg/kg, i.p.) significantly alleviated deficits myodynamia motor...
Alzheimer's disease (AD) is a neurodegenerative characterized by the deposition of amyloid-β peptides (Aβ). Aβ accumulation leads to formation neurofibrillary tangles, inflammation, axonal injury, synapse loss, and neuronal apoptosis. Thus, reducing levels should exert neuroprotective effect against AD. Ginsenoside Rf, an extract from Panax notoginseng, has potent anti-fatigue, anti-nociception, anti-oxidation, anti-inflammation properties. However, it unclear whether ginsenoside Rf...
Alzheimer's disease (AD) is the most common cause of progressive cognitive impairment in aged. The aggregation amyloid β-protein (Aβ) a hallmark AD and linked to synapse loss impairment. Capsaicin, specific agonist transient receptor potential vanilloid 1 (TRPV1), has been proven ameliorate stress-induced AD-like pathological impairments, but it unclear whether TRPV1 activation can affect synaptic functions Aβ-induced mouse model AD. In this study, we investigated effects on spatial memory...
The NLRP3 inflammasome has been shown to be involved in the development of uveitis, but exact mechanism remains elusive. This study was undertaken explore role uveitis.First, Nlrp3-deficient mice were used experimental autoimmune diseases, such as uveitis (EAU) and encephalomyelitis (EAE). Next, gathering ASC, activation caspase 1 gasdermin D, secretion lactate dehydrogenase interleukin-1β detected confirm macrophage pyroptosis AIM2 Nlrp3-/- mice. Additionally, RNA sequencing chromatin...
Abstract Maintaining a proper balance between the glutamate receptor-mediated neuronal excitation and A type of GABA receptor (GABA R) mediated inhibition is essential for brain functioning; its imbalance contributes to pathogenesis many disorders including neurodegenerative diseases mental illnesses. Here we identify novel glutamate-GABA R interaction by direct binding R. In HEK293 cells overexpressing recombinant Rs, analog ligands, while producing no current on their own, potentiate...
The hippocampus, being sensitive to stress and glucocorticoids, plays significant roles in certain types of learning memory. Therefore, the hippocampus is probably involved increasing drug use, seeking, relapse caused by stress. We have studied effect with morphine on synaptic plasticity CA1 region vivo a delayed-escape paradigm Morris water maze. Our results reveal that acute enables long-term depression (LTD) induction low-frequency stimulation (LFS) but causes potentiation. Remarkably,...
Learned association between drugs of abuse and context is essential for the formation drug conditioned place preference (CPP), which believed to engage many brain regions including hippocampus nucleus accumbens (NAc). The underlying mechanisms are not fully understood. Here, we examined whether glucocorticoid receptors (GRs) NAc influenced morphine CPP in Sprague Dawley rats. We found that systemic or intrahippocampal infused DMSO vehicle (DMSO 20% saline) 30 min before daily (10 mg/kg, sc)...
Neonatal isolation is a widely accepted model to study the long-term behavioral changes produced by early life events. However, it remains unknown whether neonatal can induce autistic-like behaviors, and if so, pharmacological treatment overcome it. Here, we reported that newborn rats subjected individual isolations from their mother nest for 1 h per day postnatal days 1-9 displayed apparent symptoms including social deficits, excessive repetitive self-grooming behavior, increased anxiety-...