A5000235462- Neuroscience and Neuropharmacology Research
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Ion channel regulation and function
- Neurological disorders and treatments
- Global Health and Surgery
- Bacteriophages and microbial interactions
- Immune Response and Inflammation
- Parkinson's Disease Mechanisms and Treatments
- Cytokine Signaling Pathways and Interactions
- HIV, Drug Use, Sexual Risk
- Escherichia coli research studies
- Immunotherapy and Immune Responses
- Global Health Workforce Issues
- Neurological Disorders and Treatments
- Protein Kinase Regulation and GTPase Signaling
- Misinformation and Its Impacts
- T-cell and B-cell Immunology
- Trace Elements in Health
- PI3K/AKT/mTOR signaling in cancer
- Health and Medical Research Impacts
- Monoclonal and Polyclonal Antibodies Research
- Advanced Glycation End Products research
- Cardiac electrophysiology and arrhythmias
- Cell death mechanisms and regulation
Royal Brisbane and Women's Hospital
2025
Government of Canada
2018
University of British Columbia
2013-2017
Mitacs
2017
Vancouver Coastal Health
2013-2016
Vancouver Coastal Health Research Institute
2013
St. Boniface Hospital
2009
Stroke is the leading cause of disability in developed countries. However, no treatment available beyond 3 h post-ictus. Here, we report that nuclear translocation PTEN (phosphatase and tensin homolog deleted on chromosome TEN) a delayed step causatively to excitotoxic ( vitro ) ischemic vivo neuronal injuries. We found stimulation N -methyl- d -aspartate (NMDA) resulted cultured neurons, process requiring mono-ubiquitination at lysine 13 residue (K13), as was prevented by mutation K13 or...
Excitotoxicity, due to overstimulation of N-methyl D-aspartate receptors (NMDARs), has a pivotal role in many neurological disorders. However, NMDAR antagonists often cause side effects, and identifying more druggable therapeutic targets for excitotoxicity is an important goal. Activation caspases downstream effect that may be critically involved NMDAR-mediated cell death. Caspase-6 (casp6) particular been shown play key the pathogenesis stroke, Huntington disease, Alzheimer disease. Using...
Anti-carbohydrate antibodies (Abs) play crucial roles in pathogen control, but their generation remains poorly understood. By studying responses to Streptococcus pyogenes humans, we reveal that the glycan-targeted response shifts from IgM towards IgG and IgA memory with age antigen exposure across blood, spleen, tonsils. Both natural colonization controlled human infection S. increased class-switched B cells, evidence of within-clone switching. Glycan-specific cells readily participated...
Policy-makers are confronted with complex problems that require evaluating multiple streams of evidence and weighing competing interests to develop implement solutions. However, the policy interventions available resolve these have different levels supporting scientific evidence. Decision-makers, who not necessarily scientifically trained, may favour policies limited backing obtain public support. We illustrate tensions two case studies where consensus went up against governing parties’...
Abstract BACKGROUND Huntington’s Disease (HD) is an autosomal dominant neurodegenerative disease causing severe neurodegeneration of the striatum as well marked cognitive and motor disabilities. Excitotoxicity, caused by overstimulation NMDA receptors (NMDARs) has been shown to have a key role in neuropathogenesis HD, suggesting that targeting NMDAR-dependent signaling may be effective clinical approach for HD. However, broad NMDAR antagonists are generally poor therapeutics practice. It...