A5101767042- Ocular Diseases and Behçet’s Syndrome
- interferon and immune responses
- Systemic Lupus Erythematosus Research
- Gut microbiota and health
- Microbial Natural Products and Biosynthesis
- Cytomegalovirus and herpesvirus research
- Cell death mechanisms and regulation
- Inflammasome and immune disorders
- Reproductive System and Pregnancy
- Inflammatory Bowel Disease
- Immune Response and Inflammation
- Ultrasound and Hyperthermia Applications
- NF-κB Signaling Pathways
- Mycobacterium research and diagnosis
- Subcritical and Supercritical Water Processes
- Hepatitis B Virus Studies
- Diet and metabolism studies
- Bone Tissue Engineering Materials
- Oral microbiology and periodontitis research
- MicroRNA in disease regulation
- Reproductive tract infections research
- Pancreatic function and diabetes
- Pregnancy and Medication Impact
- Actinomycetales infections and treatment
- Osteoarthritis Treatment and Mechanisms
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Lanzhou University
2024-2025
Changzhi Medical College
2024-2025
Chang Gung Memorial Hospital
2025
Gannan Normal University
2025
Xiangya Hospital Central South University
2022-2025
Central South University
2022-2025
Minzu University of China
2025
University of Electronic Science and Technology of China
2023-2025
Second Affiliated Hospital of Nanchang University
2025
Behcet's disease (BD) is a recalcitrant, multisystemic inflammatory that can lead to irreversible blindness. Microbial agents have been considered contribute the pathogenesis of this disease, but underlying mechanisms remain unclear. In study, we investigated association gut microbiome composition with BD as well its possible roles in development disease. Fecal and saliva samples were collected from 32 active patients 74 healthy controls. DNA extracted fecal was subjected metagenomic...
Gut microbiota-mediated secondary bile acids (BAs) play an important role in energy balance and host metabolism via G protein-coupled receptors and/or nuclear receptors. Emerging evidence suggests that BAs are for maintaining innate immune responses these However, the effect of on autoimmune uveitis is still unknown. Here, we demonstrate decreased microbiota-related BA concentration feces serum animals with experimental (EAU). Restoration gut pool attenuates severity EAU association...
To investigate gut microbiota composition and fecal metabolic phenotype in patients with acute anterior uveitis.Fecal DNA was extracted from 78 samples (38 uveitis (AAU) 40 family members of or sex- age-matched healthy controls) then sequenced by high-throughput 16S rDNA analysis. Gas chromatographic mass spectrometry (GC-MS) based metabolomics performed on 60 (30 AAU 30 controls).A significant difference observed beta diversity between controls. Eight genera including Roseburia were reduced...
Background Vogt-Koyanagi-Harada (VKH) disease is a multisystemic autoimmune disorder characterized by granulomatous panuveitis. Gut microbiome has been considered to play role in the pathogenesis of this but whether alternation gut was involved unclear. This study set up identify abnormalities composition VKH disease.Results Depleted butyrate-producing bacteria, lactate-producing bacteria and methanogens as well enriched Gram-negative were identified active patients, patients Mix enterotype...
The chitinase binding domain (ChBD) plays a crucial role in the properties of enzymes. To assess its impact, we cloned truncated mutant gene CaChi18B from novel chitinase-producing facultative anaerobic bacterium Chitinilyticum aquatile CSC-1, designated as CaChi18B_ΔChBDs. recombinant was successfully expressed and purified, exhibiting specific activity 3.48 U/mg on colloidal chitin, with optimal conditions at 45 °C pH 6.0, retaining over 80% temperatures up to 40 °C. Kinetic analysis...
Abstract RIPK1 is a death-domain (DD) containing kinase involved in regulating apoptosis, necroptosis and inflammation. activation known to be regulated by its DD-mediated interaction ubiquitination, though underlying mechanisms remain incompletely understood. Here we show that K627 human RIPK1-DD equivalent K612 murine key ubiquitination site regulates the overall pattern of interactions with other DD-containing proteins. K627R/K612R mutation inhibits blocks both apoptosis mediated TNFR1...
Dendritic cells (DCs) are the major antigen-presenting and play an important role in autoimmune uveitis.Emerging evidence suggests that bile acids (BAs) regulate DCs maturation.However, underlying mechanisms by which BAs function of still need to be clarified.Here, we demonstrate lithocholic acid (LCA) inhibits production pro-inflammatory cytokines expression surface molecules bone marrow-derived dendritic (BMDCs).LCA attenuates severity EAU modulating maturation splenic CD11C + MHCII high...
A 3D printed bionic trabecular bone scaffold based on nacre powder and sodium alginate is used for skull regeneration, platelet-rich fibrin accelerates repair.
Bioactivity-based molecular networking-guided fractionation enabled the isolation of three new polycyclic tetramic acids bearing cis-decalin, epicolidines A–C (1–3), along with one known compound, PF 1052 (4), from endophytic fungus Epicoccum sp. 1-042 collected in Tibet, China. Their structures were assigned on basis extensive spectroscopic data, partial hydrolysis, advanced Marfey's method, quantum chemistry calculations, and X-ray diffraction analysis. Compounds 2–4 displayed promising...
ABSTRACT Nitenpyram is a new neonicotinoid insecticide primarily used for the control of piercing–sucking pests as well fleas and lice on animals. It widely around world, concentrations detection rates in surface water groundwater are increasing. Current research has shown that nitenpyram toxic to honey bee, silkworms, other organisms, but toxicity aquatic organisms mechanisms its still unclear. This study uses zebrafish model investigate adverse effects early embryonic development...
To investigate aqueous metabolic profiles in Vogt-Koyanagi-Harada (VKH) and Behcet's disease (BD), we applied ultra-high-performance liquid chromatography equipped with quadrupole time-of flight mass spectrometry humor samples collected from these patients controls. Metabolite levels three groups were analyzed by univariate logistic regression. The differential metabolites subjected to subsequent pathway analysis MetaboAnalyst. results showed that both partial-least squares discrimination...
Behcet’s disease (BD) is associated with considerable gut microbiome changes. However, it still remains unknown how the composition of exactly affects development this disease. In study, transplantation stool samples from patients active ocular BD to mice via oral gavage was performed. This resulted in decreases three short chain fatty acids (SCFAs) including butyric acid, propionic acid and valeric feces BD-recipient group. Intestinal barrier integrity receiving damaged as shown by a...
Abstract Repairing osteochondral (OC) defect presents a significant challenge due to the intricate structural requirements and unpredictable differentiation pathways of bone marrow mesenchymal stem cells (BMSCs). To address this challenge, novel biomimetic OC hydrogel scaffold is developed that features structure soft hard components. This incorporates bilayer metal–organic frameworks (MOFs), specifically ZIF‐67 in upper layer ZIF‐8 lower layer, achieved through an situ printing process....
Patterns of disease and therapeutic responses vary widely among patients with autoimmune glomerulonephritis. This study introduces groundbreaking personalized infrared (IR)-based diagnostics for real-time monitoring status treatment in lupus nephritis (LN). We have established a relative absorption difference (RAD) equation to assess characteristic spectral indices based on the temporal peak heights (PHs) two serum bands: ν1 as target signal ν2 PH reference band, measured at each dehydration...
Enhancing defective cartilage repair by creating a bionic hydrogel supplemented with in situ electromagnetic stimulation, replicating endogenous effects, remains challenging. To achieve this, unique three-phase solvent system is designed to prepare magnetoelectric incorporating piezoelectric poly(3-hydroxybutyric acid-3-hydroxyvaleric acid) (PHBV) and magnetostrictive triiron tetraoxide nanoparticles (Fe3O4 NPs) into sodium alginate (SA) form dual-network, semi-crosslinked chain entanglement...
Abstract To establish a discriminant function model combining clinical data and multimodal ultrasound to predict the degree of renal fibrosis in patients with chronic kidney disease (CKD) explore application value non-invasive assessment by new techniques. Clinical ultrasonography, shear wave elastography, angio planewave ultrasensitive imaging characteristics CKD were collected. The significant indicators screened models distinguish fibrosis, diagnostic efficacy was evaluated. 158 divided...