A5065747383- Photosynthetic Processes and Mechanisms
- Natural Compound Pharmacology Studies
- Phytochemistry and Biological Activities
- Hemoglobin structure and function
- Nitric Oxide and Endothelin Effects
- Synthesis of Organic Compounds
- Metal-Catalyzed Oxygenation Mechanisms
- Renin-Angiotensin System Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Protein Structure and Dynamics
- Cancer-related molecular mechanisms research
- Acute Lymphoblastic Leukemia research
- Pharmacogenetics and Drug Metabolism
- Bacterial Genetics and Biotechnology
- Porphyrin Metabolism and Disorders
- Medicinal Plant Extracts Effects
- Photoreceptor and optogenetics research
- Natural product bioactivities and synthesis
- Breast Cancer Treatment Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mitochondrial Function and Pathology
- Histone Deacetylase Inhibitors Research
- Biomarkers in Disease Mechanisms
- Breast Lesions and Carcinomas
- Bacterial biofilms and quorum sensing
Dartmouth College
2013-2025
Wenzhou Institute of Technology Testing & Calibration
2020-2024
Affiliated Hospital of Southwest Medical University
2019-2024
Dartmouth Hospital
2024
Sir Run Run Shaw Hospital
2024
Zhejiang University
2024
Huaiyin Normal University
2023
Obstetrics and Gynecology Hospital of Fudan University
2023
Macau University of Science and Technology
2019-2021
Jiangxi University of Science and Technology
2021
Significance Pseudomonas aeruginosa , a versatile bacterium that lives in environmental habitats and causes life-threatening opportunistic infections, uses quorum sensing to coordinate gene expression. The lasR gene, which encodes quorum-sensing regulator, is often found have loss-of-function mutations clinical isolates. Interestingly, LasR− strains high activity of the oxygen-sensitive transcription factor Anr microoxic conditions. This report identifies characterizes an Anr-regulated...
It has been suggested that the alkaline form of cytochrome c (cyt c) regulates function this protein as an electron carrier in oxidative phosphorylation and a peroxidase reacts with cardiolipin (CL) during apoptosis. In form, Met80, native ligand to heme iron, is replaced by Lys. While it become clear structure cyt changes, extent sequence conformational rearrangements associated replacement remain subject debate. Herein we report high-resolution crystal Lys73-ligated conformation reveals...
Significance Metal thiolates are common components of electron transfer proteins, enzymes, and redox sensors. Reduction ferric thiolate hemes often involves protonation the Cys ligand loss or substitution. These reactions contribute to enzyme inactivation form basis sensing functions, but their mechanistic details not well understood, particularly in proteins. A neutral thiol is a viable heme; however, analysis this interaction has been challenging. Herein, we describe series model proteins...
The coordination sphere of the two Fe( iii ) ions in HLP from Azotobacter vinelandii is same as mycobacterial HLPs but an outer-sphere Thr-to-Phe substitution required for presence a μ-oxo bridge and reactivity toward NO.
Abstract Microsatellite instability (MSI) has emerged as an important predictor of sensitivity for immunotherapy-based strategies. β-2-Microglobulin (B2M) contains microsatellites within the coding regions and is prone to somatic changes in MSI/mismatch repair deficiency (MSI/dMMR) tumors. To delineate prevalence associations B2M mutations MSI-H/dMMR cancers, we investigated mutational profile clinical pathological features gastric cancer (GC), colorectal (CRC), endometrial (EC) with a high...
Returning crop straw to the field not only improves nitrogen (N) supplying capacity and N retention of soil but also decreases amount rural organic waste prevents air pollution. Therefore, understanding mechanisms release re-adsorption dynamics on residue during decomposition in agricultural is important, this can help us strengthen fertilizer management growth period. An on-farm incubation experiment was conducted Jianghan Plain Central China under flooded conditions using nylon mesh bag...
Context Due to the poor prognosis of T-cell acute lymphoblastic leukaemia (T-ALL), there is an urgent need identify safer and more cost-effective drugs.Objective This study evaluated antitumour activity Shuanghuanglian (SHL) on T-ALL cells elucidated mechanism.Materials methods Jurkat Molt4 were treated with SHL (0.1, 0.2 0.4 mg/mL) for 24 48 h. The controls RPMI 1640 containing 10% foetal bovine serum. Cell viability was through Counting Kit-8 assay. Patterns death signalling pathway...
Abstract Five new xanthones, namely Garcinexanthones A–E (1–5), were isolated from the barks of Garcinia xanthochymus . Their structures elucidated by spectral analysis, primarily NMR, MS, and UV. The complete assignments 1 H NMR 13 C chemical shifts for compounds achieved using 1D 2D techniques, including DEPT, HSQC, HMBC experiments. Copyright © 2008 John Wiley & Sons, Ltd.
Abstract Five new xanthones, garcinenone A ( 1 ), B 3 C 4 D 7 ) and E 8 along with known compounds were isolated from the EtOAc‐soluble extract of bark Garcinia xanthochymus , their structures elucidated by spectroscopic methods, especially 2D‐NMR techniques. Jacareubin 2 1,4,6‐trihydroxy‐5‐methoxy‐7‐(3‐methyl‐2‐butenyl)xanthone 6 subeliptenone 11 symphoxanthone 12 obtained this plant for first time. The exhibited potent antioxidant activity in 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) radical...
Met80, one of the heme iron ligands in cytochrome c (cyt c), is readily oxidized to Met sulfoxide (Met-SO) by several biologically relevant oxidants. The modification has been suggested affect both electron-transfer (ET) and apoptotic functions this metalloprotein. coordination Met-oxidized cyt (Met-SO c) critical for these but remained poorly defined. We present electronic absorption, NMR, EPR spectroscopic investigations as well kinetic studies mutational analyses identify yeast iso-1...
Abstract A new bis‐xanthone (xanthone=9 H ‐xanthen‐9‐one), named bigarcinenone ( 1 ) which is the first example of a with xanthone–xanthone linkage between an aromatic C‐atom and C 5 side chain from guttiferae plant, phloroglucinol (=benzene‐1,3,5‐triol) derivative, garcinenone F 2 ), together seven known xanthones were isolated bark Garcinia xanthochymus. Their structures elucidated by spectroscopic methods, especially 2D‐NMR techniques. Bigarcinenone exhibited potent antioxidant activity...
Abstract A new xanthone derivative, garcinexanthone F ( 1 ), which was found to possess an α , β ‐unsaturated γ ‐lactone moiety, and a bisxanthone, bigarcinenone B 2 with terpene bridge providing the xanthonexanthone linkage, were isolated from bark of Garcinia xanthochymus. Their structures elucidated by spectroscopic methods, especially 2D‐NMR techniques. The antioxidant assay in vitro showed that compounds exhibited significant scavenging activities against 1,1‐diphenyl‐2‐picrylhydrazyl...