A5101731259- Breast Cancer Treatment Studies
- Lymphoma Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Liver physiology and pathology
- CNS Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cancer and Skin Lesions
- Metastasis and carcinoma case studies
- HER2/EGFR in Cancer Research
- Genetic factors in colorectal cancer
- Chronic Lymphocytic Leukemia Research
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Cells and Metastasis
- AI in cancer detection
- Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Cutaneous lymphoproliferative disorders research
- Cancer Treatment and Pharmacology
- Glaucoma and retinal disorders
- Ubiquitin and proteasome pathways
- Monoclonal and Polyclonal Antibodies Research
- Microscopic Colitis
- Vascular Tumors and Angiosarcomas
Fudan University Shanghai Cancer Center
2015-2025
Shanghai Medical College of Fudan University
2014-2025
Fudan University
2008-2024
Affiliated Hospital of Jining Medical University
2018-2023
Hebei Medical University
2023
Fourth Hospital of Hebei Medical University
2023
Qingdao University
2018-2021
Affiliated Hospital of Qingdao University
2018-2021
AstraZeneca (United States)
2020
Jinan University
2014
Background Ki67 labeling index (LI) is critical for treatment options and prognosis evaluation in breast cancer. Visual assessment (VA) widely used to assess LI, but has some limitations. In this study, we compared the consistency between VA automated digital image analysis (DIA) of LI cancer, evaluate application value DIA assessment. Methods immunostained slides 155 cases primary invasive cancer were eyeballing assessed by five pathologists analyzed one pathologist respectively. Two score...
GATA-binding protein 3 (GATA3) is a sensitive and relatively specific marker in breast urothelial carcinomas. Its diagnostic utility primary metastatic cancers has been explored confirmed. However, the relationship between GATA3 expression different carcinoma intrinsic subtypes not specifically defined literature despite few reports with small number of cases. The aim current investigation to clarify among histological surrogate molecular large series cases.Immunohistochemical staining...
Ki67 labeling index (LI) is used as a predictive marker and associated with prognosis in breast cancer. However, standardised methodologies for measurement are lacking which has limited its application clinical practice. In this study, we evaluated the interobserver concordance of visual assessment LI cancer.Ki67-immunostained slides 160 cases primary invasive cancer were assessed by five pathologists two different methods to choose scoring fields: (1) hot-spot score, (2) average score....
This retrospective study aimed to evaluate the efficacy and safety of PBVD (pegylated liposomal doxorubicin [PLD], bleomycin, vinblastine, dacarbazine) in first-line treatment classical Hodgkin lymphoma (cHL) patients with cardiovascular risk factors. Overall, 84 (53 had stage I–II 31 III–IV disease) received PBVD. The median PLD duration was 16 weeks (interquartile range [IQR]: 8–24) for 24 (IQR: 12–24) III–IV. Among them, 56 (66.7%) radiotherapy (45 11 disease). Seventy-four (88.1%)...
Aims To study the clinicopathological, immunohistochemical and molecular features of carcinoma arising in microglandular adenosis (MGACA) breast. Methods Clinicopathological 13 cases MGACA were analysed. All tumours subtype by immunohistochemistry (IHC) AR, CD8, FOXC1 DCLK1 expression. Next-generation sequencing including 511 genes was Results showed a histological spectrum ranging from (MGA) to atypical MGA (AMGA), ductal situ (DCIS) MGACA. Invasive components 10 invasive no special type...
Abstract Purpose: BATF2, a novel IFN-stimulated gene, inhibits tumor cell proliferation, invasion, and migration. The objectives of this study were to determine how BATF2 expression is associated with colorectal cancer progression patient outcome, investigate overexpression hepatocyte growth factor (HGF)/MET signaling, elucidate the rationale for combining MET inhibitors IFN. Experimental Design: in tissues was determined correlated prognosis. Cultured cells used effects on malignant...
Triple-negative breast cancers (TNBCs) are a group of heterogeneous diseases with various morphology, prognosis, and treatment response. Therefore, it is important to identify valuable biomarkers predict the therapeutic response prognosis for TNBCs. Tumor-infiltrating lymphocytes (TILs) may have predictive value pathological complete (pCR) in neoadjuvant treated However, absence standardized methodologies TILs measurement has limited its evaluation application practice. In 2014,...
The PI3K/AKT pathway might be involved in the development of some certain diffuse large B-cell lymphoma (DLBCL) by as-yet unclear mechanisms. PIK3CA mutations exons 9 and 20 were investigated 76 primary human DLBCLs, 3 DLBCL cell lines (LY1, LY8, LY10), related samples using polymerase chain reaction-based sequence analysis to assess possible relevance activation. AKT phosphorylation (pAKT) was also detected Western blot immunohistochemistry. All showed high levels pAKT, 72.4% (55/76) DLBCLs...
Plasma extracellular vesicles (EVs) have been reported to be a promising source of diagnostic and prognostic biomarkers in various cancers. However, further research this area is needed due the limitations circulating detection methods. Using Single Molecule array (SiMoa) technology, we developed two vesicle assays, CD9-CD63 PD-L1-CD63, determine universal EVs PD-L1 positive EVs, respectively. A total 164 diffuse large B-cell lymphoma (DLBCL) patients were retrospectively included study....
Background:Expert consensus on BRCA1/2 genetic testing and clinical application in Chinese breast cancer patients recommends that should be performed those with risk factors, such as an early onset, triple-negative (TNBC) or family history of cancer. With the increasing multigene panels, for genes beyond has become more prevalent. However, non-BRCA mutation status high-risk not been fully explored. Methods: A total 230 from Fudan University Shanghai Cancer Center who had undergone peripheral...
Aims Human epidermal growth factor receptor 2 (HER2)-positive patients with breast cancer may have different HER2/CEP17 ratios and HER2 copy numbers, inconsistent responses to anti-HER2 neoadjuvant chemotherapy (NACT). Our study aimed explore the relationship between fluorescence in situ hybridisation (FISH) patterns HER2-positive NACT. Methods 527 invasive who received NACT from 2015 2022 were included divided into three groups by FISH results, namely group A: HER2/CEP17<2.0 numbers...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers, partly due to its high level drug resistance. β-Catenin critical for resistance in pancreatic cancer, which occurs through multiple mechanisms. Here, we observed that miR-33a targeted 3′UTR β-catenin, inducing apoptosis and inhibiting growth human cancer cells. Moreover, gemcitabine (GEM) treatment enhanced β-catenin expression by reducing a dose-dependent manner. GEM-resistant MiaPaCa-2res cells with low adopted...
Dihydroartemisinin (DHA), a semisynthetic derivative of artemisinin isolated from the traditional Chinese herb Artemisia annua, is an effective novel antimalarial drug. Recent studies suggest that it also has anticancer effects. The present study investigated apoptosis activity DHA in cultured human lung cancer cells by terminal deoxynucleotidyl transferase dUTP nick-end labelling (TUNEL) assay and flow cytometry. Intracellular free calcium concentrations were evaluated laser scanning...
Abstract Some histone deacetylases (HDACs) promote tumor cell growth and pan‐ or selective HDAC inhibitors are active in some cancers; however, the pivotal enzyme its functions human diffuse large B‐cell lymphoma (DLBCL) remain largely unknown. Using NanoString nCounter assays, we profiled mRNA expression identified HDAC6 as an upregulated family member DLBCL tissue samples. We then found that plays oncogenic role DLBCL, evidenced by promotion of proliferation vitro xenograft vivo ....
Abstract Purpose Large B‐cell lymphoma with IRF4 rearrangement (LBCL, +) has been recently recognized as a specific entity that is frequently associated young age and favorable prognosis. However, whether the good outcome of disease due to + or other factors remains obscure. We thus analyzed 100 patients primary head neck LBCL see clinicopathologic correlates +. Methods The histopathology, immunophenotype, status tumors, clinical data were reviewed. Results Twenty‐one tumors diagnosed LBCL,...
Aims Pure mucinous carcinoma (PMC) of the breast is a low‐grade cancer. In this study, we aimed to elucidate prognostic significance micropapillary structures in PMC. Methods and results Seventy‐five patients with PMC were recruited. All haematoxylin eosin (H&)‐stained slides reviewed, clinicopathological features including age, tumour size, growth pattern, nuclear grade, histological lymph node (LN) status, immunohistochemistry (IHC) staining hormone receptor, human epidermal factor...