Primary liver tumors (PLCs) and metastasis currently represent the leading cause of cancer-related deaths worldwide due to poor outcomes, high incidence, postsurgical recurrence. Hence, novel diagnostic markers therapeutic strategies for PLCs are urgently needed. The human microbiome can directly or indirectly impact cancer initiation, progression, response therapy, including immunotherapy; however, roles microbiota in tumor microenvironment not clear require more investigation. Here, we...

Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) is a highly aggressive malignancy with inferior outcomes after treatment, which might be largely attributed to the immune escape induced by EBV via modulation of checkpoint programmed cell death 1 (PD-1)/PD-ligand (PD-L1). This study aimed explore role that EBV-encoded latent membrane protein 2A (LMP2A) played in mechanisms EBV+ DLBCL cells. Ten cases each and without immunohistochemical expression LMP2A were submitted...

EBV + inflammatory follicular dendritic cell (FDC) sarcoma is an indolent malignant neoplasm of spindled FDCs with a rich lymphoplasmacytic infiltrate and consistent association Epstein-Barr virus (EBV). It occurs exclusively in the liver spleen, exception few colonic examples. In this study, we report 9 extrahepatosplenic cases, including 4 occurring previously undescribed sites, but all apparently anatomically related to aerodigestive tract. The cases included 5 gastrointestinal tumors...

Abstract Purpose Large B‐cell lymphoma with IRF4 rearrangement (LBCL, +) has been recently recognized as a specific entity that is frequently associated young age and favorable prognosis. However, whether the good outcome of disease due to + or other factors remains obscure. We thus analyzed 100 patients primary head neck LBCL see clinicopathologic correlates +. Methods The histopathology, immunophenotype, status tumors, clinical data were reviewed. Results Twenty‐one tumors diagnosed LBCL,...

The well-established cell-of-origin (COO) algorithm categorizes diffuse large B-cell lymphoma (DLBCL) into activated B-cell-like (ABC) and germinal center (GCB) subgroups through gene expression profiling. We aimed to develop validate a qPCR-based assay determine the COO of DLBCL with formalin-fixed paraffin-embedded (FFPE) tissue. first established transcriptome database 1,016 samples retrieved from three published datasets (GSE10846, GSE22470, GSE31312). With this database, we identified...

Pediatric-type follicular lymphoma (PTFL) is a rare pediatric-type indolent B-cell that clinicopathologically differs from adult lymphoma. Accurate diagnosis of PTFL, which often challenging, essential to avoid missed diagnosis, misdiagnosis, and overtreatment. To improve our understanding clinicopathological features, differential molecular mutation characteristics four patients PTFL were analyzed using hematoxylin eosin staining, immunohistochemistry, polymerase chain reaction,...

DIXDC1 (Dishevelled-Axin domain containing 1) is a positive regulator of the Wnt pathway. In field cancer research, role unclear. Our previous in vitro study showed that enhances β-catenin nuclear accumulation gastric cell lines. The aim this was to detect expression different histological subtypes carcinoma and evaluate correlation between localization clinicopathological parameters, including patients' survival.Immunohistochemical staining performed characterize archived materials from 259...

Abstract The prognostic value of histologic grading and the Ki‐67 proliferation index in follicular lymphoma (FL) is controversial. This study investigated clinical usefulness these two factors Asian FL patients. Four hundred thirty‐three patients diagnosed with were retrospectively reviewed a median follow‐up time 47.0 months (range, 24.0‐168.0). 10‐year overall survival (OS) rate progression‐free (PFS) 91.0% 47.1%, respectively. Grade 3B grade diffuse large B cell (DLBCL) showed better PFS...

MYC overexpression is a common feature of diffuse large B-cell lymphoma (DLBCL) and associated with poor prognosis in patients this neoplasm. We aimed to investigate the underlying mechanisms dysregulation, as they have not been fully determined.We immunohistochemically evaluated correlation between receptor (BCR)-phosphoinositide 3-kinase (PI3K) pathway activity level 108 cases de-novo DLBCL, 25 which featured loss BCR, investigated effects BCR-PI3K signalling on phosphorylation DLBCL cell...

To investigate the efficacy and safety of bupivacaine liposome for pericapsular nerve group block (PENGB) postoperative analgesia in elderly patients with total hip replacement.

Recent studies have demonstrated the benefits of metformin on patients with lymphomas. B-cell receptor (BCR)-PI3K-AKT pathway-dependent cholesterol synthesis may represent a positive feedback mechanism responsible for pathogenesis BCR-dependent diffuse large lymphomas (DLBCLs). Thus, restriction lipid would affect integrity lipid-forming membranes and block BCR signaling pathway. Our in vitro findings suggested that blocking effect pathway is possibly exerted via biosynthesis cholesterol. A...

Aims Programmed death-ligand 1 (PD-L1) is known to be highly expressed in various malignancies, including head and neck squamous cell carcinoma (HNSCC). We aimed determine the prevalence of PD-L1 expression recurrent or metastatic HNSCC (R/M HNSCC) among Chinese patients. Methods This multicentre, retrospective analysis data from six centres China included patients with R/M treated 9 August 2021 28 February 2022. tumour tissue was assessed represented using a combined positive score (CPS)....

Objective: To investigate the clinical pathological features, diagnosis and differential of hybrid schwannoma/perineurioma. Methods: The clinicopathological data 35 cases were collected at Fudan University Shanghai Cancer Center, from October 2010 to August 2017; morphological observation immunohistochemical staining performed, literatures also reviewed. Results: There 7 males 28 females (male∶female=1∶4), patients with onset age ranging 3 81 years(mean=36 years). Of tumors, 11 occurred in...

Pediatric-type follicular lymphoma (PTFL) and pediatric nodal marginal zone (PNMZL) are two rare indolent B-cell lymphomas with overlapping features. Recently, cases showing hybridizing features of PTFL PNMZL have been reported. Herein, we retrospectively analyzed the clinicopathologic 59 patients, including 39 PTFL, 5 PNMZL, 15 mixed-type tumors (MTT). And next-generation sequencing analysis was performed on 3 2 MTT cases. In addition, previously published mutational data 96 PTFLs, 25...

Diffuse Large B-Cell Lymphoma (DLBCL) is the most common lymphoid malignancy in adults, which often takes a nonlymph nodes organ as primary focus. Primary of thyroid gland not clinic, EBV-positive diffuse large B-cell lymphoma rare and its pathogenesis, treatment prognosis are rarely studied. We reported an 85-year-old female patient with gland, disease eventually relapsed skeletal muscle patient. The pathological type after relapse was consistent that As far we know secondary DLBCL from...

Pediatric follicular lymphoma (PTFL) is one of the rare pediatric-type indolent B-cell lymphomas that clinicopathologically differs from adult lymphoma. Accurate diagnosis PTFL essential to avoid leak-diagnosis, misdiagnosis and overtreatment, but it often challenging. To improve understanding PTFL, we collected four cases analyzed clinicopathological features, differential molecular mutation characteristics by hematoxylin‑eosin stain, immunohistochemistry, polymerase chain reaction (PCR),...

Abstract Programmed death-ligand 1 (PD-L1) is a trans-membrane protein and co-inhibitory factor of the immune response. PD-L1 can combine with its receptor (PD-1) to reduce proliferation PD-1-positive cells induce apoptosis. Therefore, was employed as prognostic marker target for anti-cancer immunotherapy in blocking PD-1 checkpoints. highly expressed various malignancies, including head neck squamous cell carcinoma (HNSCC). HNSCC sixth most common cancer worldwide, high incidence mortality...

Background: Anaplastic lymphoma kinase-positive large B-cell (ALK+ LBCL) is a rare neoplasm of B-cells with plasmablastic immunophenotype and ALK expression due to rearrangements. The molecular genetic profile the disease, however, remains largely unknown. Design: Clinicopathologic features 10 cases ALK+ LBCL 12 ALK-negative were retrospectively analyzed. mutational landscapes revealed by screening targeted panel 136 genes using next-generation sequencing formalin-fixed, paraffin-embedded...

Background: Human epidermal growth factor receptor 2 (HER2) is crucial for the development and targeted therapy of gastric carcinoma. GC highly heterogeneous. In current clinical practice, however, accurate assessment HER2 status cannot be achieved in surgical specimens. Methods: All formalin-fixed paraffin-embedded (FFPE) samples 2627 surgically resected specimens carcinoma were analyzed with immunohistochemistry (IHC) methods. Based on Monte Carlo method MATLAB software, 3+ positivity rate...

Background: EBV+ DLBCL is an aggressive malignancy that largely resistant to current therapeutic regimens. LMP2A expressed during different latency stages of EBV-infected B cells in which it triggers activation cytoplasmic protein tyrosine kinases. Early studies have revealed immunoreceptor tyrosine-based motif the N-terminus can trigger a transient increase cytosolic Ca2+ concentration similar observed activated cells. Meanwhile, tumor often express PD-L1 DLBCL, providing possible mechanism...

Background: B-cells can function as antigen presenting cells by antigens captured the B-cell receptor (BCR) on Class II Major Histocompatibility Complex (MHCII) to T-cells. In addition, also maintain immune homeostasis expressing PD-L1 and suppress T-cell activity. Epstein-Barr virus (EBV) infection disrupt lead malignancies, including diffuse large lymphoma (DLBCL). Here we show that EBV-positive DLBCL (EBV+ DLBCL) has decreased BCR MHCII expression, but over-expressed PD-L1, which may...