A5081738795- Heavy Metal Exposure and Toxicity
- Analytical chemistry methods development
- Nanoparticles: synthesis and applications
- Chromium effects and bioremediation
- Mass Spectrometry Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Mercury impact and mitigation studies
- Trace Elements in Health
- Graphene and Nanomaterials Applications
- Air Quality and Health Impacts
- Electrochemical Analysis and Applications
- Adsorption and biosorption for pollutant removal
- Gut microbiota and health
- X-ray Spectroscopy and Fluorescence Analysis
- Metabolomics and Mass Spectrometry Studies
- Advanced Proteomics Techniques and Applications
- Drug Transport and Resistance Mechanisms
- Biosensors and Analytical Detection
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Quantum Dots Synthesis And Properties
- Pharmacological Effects and Toxicity Studies
- Advanced Nanomaterials in Catalysis
- Iron Metabolism and Disorders
- Anesthesia and Neurotoxicity Research
Chinese Academy of Sciences
2016-2025
Institute of High Energy Physics
2016-2025
First Affiliated Hospital of Guangdong Pharmaceutical University
2025
First Hospital of Jilin University
2025
Jilin University
2025
Ocean University of China
2025
Harbin Medical University
2024-2025
Second Affiliated Hospital of Harbin Medical University
2024-2025
Education Department of Heilongjiang Province
2024-2025
Hebei Academy of Agriculture and Forestry Sciences
2025
Before researchers apply nanomaterials (NMs) in biomedicine, they need to understand the blood circulation and clearance profile of these materials vivo. These qualities determine balance between nanomaterial-induced activity unwanted toxicity. NMs have heterogeneous characteristics: combine bulk properties solids with mobility molecules, their highly active contact interfaces exhibit diverse functionalities. Any new unexpected features patterns are great concern toxicological studies...
Abstract Carbon nanotubes (CNTs) hold promise in manufacturing, environmental, and biomedical applications, as well food agricultural industries. Previous observations have shown that CNTs antimicrobial activity; however, the impact of to human gut microbes has not been investigated. Here, antibacterial activity against commonly encountered digestion system— L. acidophilus , B. adolescentis E. coli faecalis S. aureus —are evaluated. The bacteria studied include pathogenic non‐pathogenic,...
Exposure to nanoparticles has presented potential risks human cardiorespiratory systems. Pulmonary retention and extrapulmonary redistribution of inhaled have been considered be important contributing factors diseases. In the present work, 22-nm 59Fe2O3 (radioactive isotope 59Fe-labeled ferric oxide nanoparticles) were intratracheally instilled into male Sprague-Dawley rats at a dose 4 mg/rat. Extrapulmonary distribution in organs its metabolism lung, blood, urine, feces measured for 50 days...
A wide range of nanoparticles (NPs) have been found to generate free radicals in biological systems. Hence, it is hypothesized that radical generation may play a key role the mechanism nanomaterial toxicity vivo. However, main physicochemical basis for particularly biomicroenvironment has not yet fully established. In this study, we performed comprehensive spectroscopic techniques probe origin induced by iron oxide biomicroenvironment. We demonstrated α-Fe2O3 and γ-Fe2O3 NPs hydroxyl (•OH)...
Two-dimensional (2D) nanosheets (NSs) have a large surface area, high free energy, and ultrathin structure, which enable them to more easily penetrate biological membranes promote adsorption of drugs proteins. NSs are capable adsorbing amount blood proteins form NSs-protein corona complexes; however, their inflammatory effects still unknown. Therefore, we investigated the pro-inflammatory effect 2D model nanosheet structures, molybdenum disulfide (MoS2), MoS2 complexes with four abundant in...
Abstract Inflammatory bowel diseases (IBD) are widespread inflammatory that cause debilitating health problems including cancer. In this study, we show ZnO nanoparticle (ZnONP) treatment has markedly dose-dependent effects on the remission of dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. We demonstrate mechanism involves antioxidant and anti-inflammatory abilities ZnONPs to suppress ROS malondialdehyde (MDA) production; increase GSH level; proinflammatory cytokines IL-1β...
Abstract Background To effectively applied nanomaterials (NMs) in medicine, one of the top priorities is to address a better understanding possible sub-organ transfer, clearance routes, and potential toxicity NMs liver kidney. Results Here we explored how surface chemistry polyethylene glycol (PEG), chitosan (CS), polyethylenimine (PEI) capped gold nanoparticles (GNPs) governs their biodistribution, profiles kidney after intravenous injection mice. The PEG-GNPs maintained dispersion...
Recent epidemiologic researches indicate that exposure to ultrafine particles (nanoparticles) is an independent risk factor for several cardiovascular diseases. The induction of endothelial injuries hypothesized be attractive mechanism involved in these To investigate this hypothesis, the widely used iron nanomaterials, ferric oxide (Fe2O3) and ferriferrous (Fe3O4) nanoparticles were incubated with human umbilical cells (ECV304 cells) at different concentrations 2, 20, 100 microg/mL. cell...
Abstract Evaluation of systemic biosafety nanomaterials urgently demands a comprehensive understanding the mechanisms undesirable interference and signaling that arises between man‐made biological systems. It is shown exosomes may act as signal conveyors for nanoparticle‐induced immune responses. Exosomes are extracellularly secreted membrane vesicles which Trojan horses dissemination intercellular communication natural nanosized particles (like viruses). Upon exposure to magnetic iron oxide...
Single cell analysis has become an important field of research in recent years reflecting the heterogeneity cellular responses biological systems. Here, we demonstrate a new method, based on laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS), which can quantify situ gold nanoparticles (Au NPs) single cells. Dried residues picoliter droplets ejected by commercial inkjet printer were used to simulate matrix-matched calibration standards. The cells exposed 100 nM NIST Au NPs...
Novel single cell techniques are attracting growing interest for clinical applications, because they can elucidate the cellular diversity and heterogeneity instead of average masked by bulk measurements. Herein, time-resolved ICP-MS determination essential mineral elements in cells has been developed is used to analyze contents distribution patterns Fe, Cu, Zn, Mn, P S two types cancer (HeLa A549) one type normal (16HBE). The results show that there obvious differences among three cells....
With the increasing production and widespread potential applications of single-walled carbon nanotubes (SWCNTs), possible impacts oral administration SWCNTs on gastrointestinal tract at currently occupational exposure limits biomedical should be concerned. To address concerns, mice are orally administrated doses 0.05, 0.5, 2.5 mg kg-1 body weight per day for 7 d. The investigation shows that SWCNT treatment had promoted intestinal injuries acute dose day, including increase histological...
Quantitative analysis of proteins is an essential part and also constitutes a major challenge in modern proteomics. Quantification by inductively coupled plasma mass spectrometry (ICPMS) offers alternative method for quantitative In this study, we developed absolute quantification via sulfur size exclusion chromatography (SEC) to ICPMS with collision cell (ICP-CC-MS) postcolumn isotope dilution. Bovine serum albumin (BSA), superoxide dismutase (SOD), metallothionein-II (MT-II) served as...