A5103041998- Fullerene Chemistry and Applications
- Luminescence Properties of Advanced Materials
- Carbon Nanotubes in Composites
- Radiation Detection and Scintillator Technologies
- Graphene research and applications
- Diamond and Carbon-based Materials Research
- Advanced biosensing and bioanalysis techniques
- Solid State Laser Technologies
- Photorefractive and Nonlinear Optics
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Polymer Nanocomposite Synthesis and Irradiation
- Advanced Nanomaterials in Catalysis
- Boron and Carbon Nanomaterials Research
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Electrochemical Analysis and Applications
- Cancer Cells and Metastasis
- Extracellular vesicles in disease
- Research in Cotton Cultivation
- Perovskite Materials and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Boron Compounds in Chemistry
- Ion Transport and Channel Regulation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Chinese Academy of Sciences
2011-2025
Yueyang Hospital
2025
University of Chinese Academy of Sciences
2021-2025
Shanghai University of Traditional Chinese Medicine
2025
Fujian Institute of Research on the Structure of Matter
2023-2025
Xiamen Institute of Rare-earth Materials
2023-2025
Shanghai East Hospital
2024-2025
Institute of High Energy Physics
2007-2024
Yunnan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Antiangiogenesis is an effective strategy for cancer treatment because uncontrolled tumor growth depends on angiogenesis and sufficient blood supply. Great progress has been made in developing a “molecular” form of inhibitors; however, the narrow inhibition spectrum limits anticancer efficacy as those inhibitors that usually target few or even single angiogenic factor among many factors might initially be but ultimately lead to failure due induction expression other factors. In this work, we...
Cardiovascular diseases could be treated by chaperones that deliver the lipid mediator S1P promotes endothelial function.
WNK kinases, including WNK3, and the associated downstream Ste20/SPS1-related proline-alanine-rich protein kinase (SPAK) oxidative stress responsive 1 (OSR1) comprise an important signaling cascade that regulates cation-chloride cotransporters. Ischemia-induced stimulation of bumetanide-sensitive Na(+)-K(+)-Cl(-) cotransporter (NKCC1) plays role in pathophysiology experimental stroke, but mechanism its regulation this context is unknown. Here, we investigated WNK3-SPAK/OSR1 pathway as a...
Macrophages respond to various stimuli produce angiogenic factors but few mechanistic details are known. We examined the effects of hypoxia, lactate and nicotinamide on expression vascular endothelial growth factor by cultured macrophages. These agents were chosen because they down‐regulate polyadenosine diphosphoribose levels. Following exposure, conditioned media analyzed for protein. Nicotinamide adenine dinucleotide, diphosphoribose, mRNA measured in cellular fraction. Angiogenic...
Influences of structural properties on the stability fullerenols are studied using experimental techniques including laser-induced dissociation associated with a time-of-flight measurement, synchrotron radiation XPS, and FT-IR spectroscopy. Stabilities family (C60(OH)42, C60(OH)44, C60(OH)30, C60(OH)32, C60(OH)36) as functions parameters—the hydroxyl number, intensity impure group, ratio carbonyl to groups—are investigated. It is found that molecular largely depends quantity groups,...
Epidemiologic studies have revealed that pollution by ambient particulates is associated with respiratory and cardiovascular diseases, particularly in older people. Toxicologic sensitivity of nanoparticles different ages was investigated for the first time to demonstrate explain an age-related difference response manufactured nanoparticles. Young, adult, old rats physiologically inhaled air containing aerosol SiO2 (24.1 mg/m3; 40 min/day) four weeks. Changes serum biomarkers, hemorheologic,...
The strongly induced circular dichroism (ICD) signals of DNA wrapped around single-walled carbon nanotubes (SWCNTs) are shown by the Synchrotron Radiation Facility. In solution, trace amounts Hg ions have a strong affinity to bind nucleic bases DNA-SWCNTs via pseudo-first-order kinetic reaction. binding results in partial disassociation from SWCNTs. Such SWCNTs will decrease coupling effects transition dipole moments between and SWCNTs, thus inducing ICD signal significantly. Herein, is...
Abstract Novel boron‐containing carbon dots (BCDs) are designed and prepared for boron neutron capture therapy (BNCT) with superior water solubility excellent optical property tracking 10 B in vitro vivo. Encapsulation of BCDs using exosomes (Exos) from macrophages yields BCD–Exos ≈100 nm. Fluorescent imaging shows that the internalized distributed around nuclei U‐87‐MG glioma cells. also verified to cross blood–brain barrier significant accumulation tumor tissue orthotopic tumor‐bearing...
Quantitative analysis of proteins is an essential part and also constitutes a major challenge in modern proteomics. Quantification by inductively coupled plasma mass spectrometry (ICPMS) offers alternative method for quantitative In this study, we developed absolute quantification via sulfur size exclusion chromatography (SEC) to ICPMS with collision cell (ICP-CC-MS) postcolumn isotope dilution. Bovine serum albumin (BSA), superoxide dismutase (SOD), metallothionein-II (MT-II) served as...
Accurate prediction of the relative biological effectiveness (RBE) boron neutron capture therapy (BNCT) is challenging. The different from other radiotherapy; dynamic distribution boron-containing compounds in tumor cells affects therapeutic outcome considerably and hampers accurate measurement neutron-absorbed dose. Herein, we used metal-organic framework nanoparticles (BMOFs) with high content to target U87-MG maintain concentration 10B isotope cells. could 90% (60 ppm) within 20 min...
Glioma is the most prevalent tumor of central nervous system. The poor clinical outcomes and limited therapeutic efficacy underscore urgent need for early diagnosis an optimized prognostic approach glioma. Therefore, aim this study was to identify sensitive biomarkers Differentially expressed genes (DEGs) glioma were downloaded from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. potential identified using weighted gene co-expression network analysis (WGCNA) least...
The production of stable carbon dots in large quantities for use industrial or clinical applications has remained a challenge, particularly with regard to the preservation specific functional molecular groups. Synchrotron radiation-based analytical techniques have been used study reactions occurring during formation dots. Based on this technique, reaction mechanism intramolecular competition hydrothermal synthesis was found. competitively reactive groups result slowing rapid polymerization...
Chronic wound healing remains a major challenge in diabetes management due to prolonged inflammation, autonomic neuropathy, and bacterial infections. In particular, multidrug-resistant infections are important the development of diabetic wounds, leading persistent inflammation delayed healing. To address this issue, we developed self-adaptive nanozyme designed modulate infectious inflammatory microenvironments by doping Ce Ag into mesoporous silicon nanomaterials (MSNs). The resulting...
We developed a method to synthesize paramagnetic nanoparticles of Gd@C82(OH)22±2. Such are with ordered microstructures and have strong MRI proton relaxation in vitro/vivo. Compared commercial Gd-DTPA, 12× relaxivity Gd@C82(OH)22±2 was achieved vitro. The small nanoparticles, ∼65nm, could easily escape the RES uptake vivo; this opens door for their clinical applications.
Hypoxia ischemia (HI)-related brain injury is the major cause of long-term morbidity in neonates. One characteristic hallmark neonatal HI development reactive astrogliosis hippocampus. However, impact hippocampal damage after not fully understood. In current study, we investigated role Na+/H+ exchanger isoform 1 (NHE1) protein mouse astrocyte function an vitro model (oxygen/glucose deprivation and reoxygenation, OGD/REOX). 2 h OGD significantly increased NHE1 expression NHE1-mediated H+...