A5051390360- Fullerene Chemistry and Applications
- Graphene research and applications
- Carbon Nanotubes in Composites
- Conducting polymers and applications
- Perovskite Materials and Applications
- Diamond and Carbon-based Materials Research
- Boron and Carbon Nanomaterials Research
- Electrochemical sensors and biosensors
- Graphene and Nanomaterials Applications
- Organic Electronics and Photovoltaics
- Electrochemical Analysis and Applications
- Quantum Dots Synthesis And Properties
- Polymer Nanocomposite Synthesis and Irradiation
- Advancements in Battery Materials
- Advanced biosensing and bioanalysis techniques
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Nanoparticle-Based Drug Delivery
- Solid-state spectroscopy and crystallography
- Supercapacitor Materials and Fabrication
- Carbon and Quantum Dots Applications
- Quantum, superfluid, helium dynamics
- Molecular Junctions and Nanostructures
Institute of High Energy Physics
2016-2025
Chinese Academy of Sciences
2016-2025
University of Chinese Academy of Sciences
2015-2025
Delft University of Technology
2023
China University of Petroleum, East China
2023
Institut Pasteur of Shanghai
2019
Center for Excellence in Molecular Cell Science
2019
Shenyang Jianzhu University
2019
Foundation for Biomedical Research
2018
Beijing Institute of Technology
2016
Because of their unique physical, chemical, electrical, and mechanical properties, carbon nanotubes (CNTs) have attracted a great deal research interest many potential applications. As large-scale production application CNTs increases, the general population is more likely to be exposed either directly or indirectly, which has prompted considerable attention about human health safety issues related CNTs. Although experimental data CNT toxicity at molecular, cellular, whole animal levels been...
Abstract The contemporary use of nanomedicines for cancer treatment has been largely limited to serving as carriers existing therapeutic agents. Here, we provide definitive evidence that, the metallofullerenol nanomaterial Gd@C 82 (OH) 22 , while essentially not toxic normal mammary epithelial cells, possesses intrinsic inhibitory activity against triple-negative breast cells. blocks epithelial-to-mesenchymal transition with resultant efficient elimination stem cells (CSCs) resulting in...
Cisplatin is a chemotherapeutic drug commonly used in clinics. However, acquired resistance confines its application chemotherapeutics. To overcome the to cisplatin, it reasoned, based on our previous findings of mediation cellular responses by [Gd@C 82 (OH) 22 ] n nanoparticles, that may reverse tumor cisplatin reactivating impaired endocytosis cisplatin-resistant human prostate cancer (CP-r) cells. Here we report exposure CP-r PC-3-luc cells presence nontoxic not only decreased number...
Pancreatic adenocarcinoma is the most lethal of solid tumors and fourth-leading cause cancer-related death in North America. Matrix metalloproteinases (MMPs) have long been targeted as a potential anticancer therapy because their seminal role angiogenesis extracellular matrix (ECM) degradation tumor survival invasion. However, inhibition specificity to MMPs molecular-level understanding mechanism remain largely unresolved. Here, we found that endohedral metallofullerenol Gd@C 82 (OH) 22 can...
Antiangiogenesis is an effective strategy for cancer treatment because uncontrolled tumor growth depends on angiogenesis and sufficient blood supply. Great progress has been made in developing a “molecular” form of inhibitors; however, the narrow inhibition spectrum limits anticancer efficacy as those inhibitors that usually target few or even single angiogenic factor among many factors might initially be but ultimately lead to failure due induction expression other factors. In this work, we...
Polyhydroxylated fullerenols especially gadolinium endohedral metallofullerenols (Gd@C 82 (OH) 22 ) are shown as a promising agent for antitumor chemotherapeutics and good immunoregulatory effects with low toxicity. However, their underlying mechanism remains largely unclear. We found the first time persistent uptake subcellular distribution of in macrophages by taking advantages synchrotron‐based scanning transmission X‐ray microscopy (STXM) high spatial resolution 30 nm. Gd@C can...
Intraperitoneal injection of [Gd@C<sub>82</sub>(OH)<sub>22</sub>]<sub>n</sub> nanoparticles decreased activities enzymes associated with the metabolism reactive oxygen species (ROS) in tumor-bearing mice. Several physiologically relevant ROS were directly scavenged by nanoparticles, and lipid peroxidation was inhibited this study. significantly reduced electron spin resonance (ESR) signal stable 2,2-diphenyl-1-picryhydrazyl radical measured ESR spectroscopy. Like-wise, studies using...
Aims: [Gd@C82(OH)22]n is a new type of nanoparticle with potent antineoplastic activity and low toxicity compared traditional drugs. In this study, we explored, for the first time, effect on cell cycle using human breast cancer MCF-7 umbilical vein endothelial ECV304 lines by flow cytometry. Methods: Cell viability was assessed through CCK-8 assay, tumor-bearing mice were examined after 2 weeks treatment [Gd@C82(OH)22]n. cycle-related gene expression detected microarray confirmed real-time...
An electrically bistable and non-volatile rewritable memory effect on a sandwich architecture, ITO/PEDOT:PSS/organic–inorganic hybrid perovskite/Cu, is shown.
Photon radiotherapy is a common tool in the armory against tumors, but it limited by hypoxia-related radioresistance of tumors and radiotoxicity to normal tissues. Here, we constructed spatiotemporally controlled synergistic therapy platform based on heterostructured CuO@Graphdiyne (CuO@GDY) nanocatalyst for simultaneously addressing two key problems above radiotherapy. First, situ formed Z-scheme CuO@GDY heterojunction performs highly efficient photocatalytic O2 evolution upon near-infrared...
In this paper, a superior supercapacitor nanocomposite based on porous carbon nanotubes (PCNTs), MnO2/PCNT/MnO2, was synthesized, which displayed specific capacitance (C = 341.5 F g–1, 2 mV s–1), excellent rate capability 214.3 63% capacity retention, 100 and high cyclic stability (98% efficiency after 6000 charge/discharge cycles). The outstanding improvement of its electrochemical performances resulted from the massive nanopores walls PCNTs, made more MnO2 nanoparticles filled both in...
Abstract Quasi‐2D perovskites show great potential as photovoltaic devices with superior stability, but the power conversion efficiency (PCE) is limited by poor carrier transport. Here, it simultaneously affected hole transport layer (HTL) and perovskite incorporating pyridine‐based materials into poly(3,4‐ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS) to address key problem above in 2D perovskites. With this approach, enhanced optoelectronic performance of novel PEDOT:PSS due...
Although endohedral metallofullerenol [Gd@C(82)(OH)(22)](n) nanoparticles have anti-tumor efficiency and mostly deposit in the bones of mice, how these act bone marrow stromal cells (MSCs) remains largely unknown. Herein, we observed that facilitated differentiation MSCs toward osteoblasts, as evidenced by enhancement alkaline phosphatase (ALP) activity mineralized nodule formation upon nanoparticle treatment. Mechanistically, effect on ALP was inhibited addition noggin an inhibitor BMP...
Abstract Conversion of photon into electron is a phenomenon great importance in nature. Photodetectors based on this principle have immense potential applications at the frontiers both scientific and industrial communities, thus affecting daily life. Herein, novel class high‐quality organic–inorganic trihalide perovskite nanoscale hybrid photodetectors presented carbon electrode−molecule junctions working mild conditions. Almost every figure merit with high performance, such as highest...
As one of the typical carbon nanomaterials, graphdiyne (GDY) with unique chemical, physical, and electronic properties has a great potential in various fields. Although it is an important member nanozymes, research on its intrinsic enzyme mimetic applications still limited. Herein, oxide quantum dots (GDYO QDs) have been synthesized through oxidative cleavage, which exhibit enhanced peroxidase-like activity lower Km higher Vmax than those most carbon-based nanozymes. The catalytic mechanism...