A5069374770- Carcinogens and Genotoxicity Assessment
- Plant Toxicity and Pharmacological Properties
- Toxic Organic Pollutants Impact
- Drug-Induced Hepatotoxicity and Protection
- Analytical Chemistry and Chromatography
- DNA and Nucleic Acid Chemistry
- Free Radicals and Antioxidants
- Pharmacogenetics and Drug Metabolism
- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Chemical Reaction Mechanisms
- Molecular spectroscopy and chirality
- Skin Protection and Aging
- Botanical Research and Chemistry
- Chemical Reactions and Isotopes
- Atmospheric chemistry and aerosols
- Synthesis and Biological Evaluation
- Metabolomics and Mass Spectrometry Studies
- Inorganic and Organometallic Chemistry
- Antioxidant Activity and Oxidative Stress
- DNA Repair Mechanisms
- Nanoparticles: synthesis and applications
- Retinoids in leukemia and cellular processes
- Molecular Sensors and Ion Detection
- Chemical Synthesis and Reactions
Shandong University
2025
National Center for Toxicological Research
2015-2024
United States Food and Drug Administration
2015-2024
China University of Mining and Technology
2023
Applied Materials (United States)
2022
Columbia University
2016
National Institute of Environmental Health Sciences
2000-2012
Biochemical Society
2003-2010
Center for Food Safety and Applied Nutrition
2005
Jackson State University
2002-2005
Nanotechnology has gained a great deal of public interest because the needs and applications nanomaterials in many areas human endeavors including industry, agriculture, business, medicine, health. Environmental exposure to is inevitable as become part our daily life, and, result, nanotoxicity research gaining attention. This review presents summary recent efforts on fate, behavior, toxicity different classes environment. A critical evaluation challenges future for safe environmental...
The initial metabolites in the degradation of pyrene, anthracene, fluorene, and dibenzothiophene by Pleurotus ostreatus were isolated high-pressure liquid chromatography characterized UV-visible, gas-chromatographic, mass-spectrometric, (sup1)H nuclear magnetic resonance spectral techniques. from dibenzothiophene, fluorene amounted to 45, 84, 64, 96% total organic-solvent-extractable metabolites, respectively. Pyrene was metabolized predominantly pyrene trans-4,5-dihydrodiol. Anthracene...
ABSTRACT Metabolism of the environmental pollutant benzo[ a ]pyrene in bacterium Mycobacterium vanbaalenii PYR-1 was examined. This organism initially oxidized with dioxygenases and monooxygenases at C-4,5, C-9,10, C-11,12. The metabolites were separated by reversed-phase high-performance liquid chromatography (HPLC) characterized UV-visible, mass, nuclear magnetic resonance, circular dichroism spectral analyses. major intermediates metabolism that had accumulated culture media after 96 h...
The Dark Side of Langerhans Cells Several immune cell populations reside in the skin and are thought to provide a protective barrier against infections act as sentinels malignant transformation. However, studies mice that lack cells, subset dendritic have suggested these cells may actually promote tumorigenesis. Using mouse model squamous carcinoma, Modi et al. (p. 104 ) now reveal how transformation epithelial cells. In response carcinogen 7,12-dimethylbenz[α]anthracene (DMBA), increased...
Pyrrolizidine alkaloids (PAs) are natural toxins widely distributed in plants. The toxic potencies of different PAs vary significantly. mono- or diesters necine acids with a base. On the basis bases, classified into three types: retronecine-type, otonecine-type, and platynecine-type. Hepatotoxic contain an unsaturated exert hepatotoxicity through metabolic activation by hepatic cytochromes P450s (CYPs) to generate reactive intermediates which form pyrrole-protein adducts. These adducts...
Although enzyme-like nanomaterials have been extensively investigated over the past decade, most research has focused on peroxidase-like, catalase-like, or SOD-like activity of these nanomaterials. Identifying having oxidase-like activities received less attention. In this study, we demonstrate that platinum nanoparticles (Pt NPs) exhibit catechol activity, oxidizing polyphenols into corresponding o-quinones. Four unique approaches are employed to exerted by Pt NPs. First, UV–vis...
The white rot fungus Pleurotus ostreatus, grown for 11 days in basidiomycetes rich medium containing [14C] phenanthrene, metabolized 94% of the phenanthrene added. Of total radioactivity, 3% was oxidized to CO2. Approximately 52% trans-9,10-dihydroxy-9,10-dihydrophenanthrene (phenanthrene trans-9,10-dihydrodiol) (28%), 2,2'-diphenic acid (17%), and unidentified metabolites (7%). Nonextractable accounted 35% radioactivity. were extracted with ethyl acetate, separated by reversed-phase...
Intraperitoneal injection of [Gd@C<sub>82</sub>(OH)<sub>22</sub>]<sub>n</sub> nanoparticles decreased activities enzymes associated with the metabolism reactive oxygen species (ROS) in tumor-bearing mice. Several physiologically relevant ROS were directly scavenged by nanoparticles, and lipid peroxidation was inhibited this study. significantly reduced electron spin resonance (ESR) signal stable 2,2-diphenyl-1-picryhydrazyl radical measured ESR spectroscopy. Like-wise, studies using...