A5102715682- Lung Cancer Treatments and Mutations
- Aortic Disease and Treatment Approaches
- Renal and related cancers
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Glycosylation and Glycoproteins Research
- RNA modifications and cancer
- vaccines and immunoinformatics approaches
- Click Chemistry and Applications
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Colorectal Cancer Treatments and Studies
- Aortic aneurysm repair treatments
- Cancer, Lipids, and Metabolism
- Immunotherapy and Immune Responses
- Cardiac Valve Diseases and Treatments
- Autophagy in Disease and Therapy
- Anesthesia and Neurotoxicity Research
- Macrophage Migration Inhibitory Factor
- Advanced Proteomics Techniques and Applications
- Chemical Synthesis and Analysis
- Genomics, phytochemicals, and oxidative stress
China Pharmaceutical University
2025
Second Affiliated Hospital of Xi'an Jiaotong University
2012-2024
Zhuhai People's Hospital
2022-2024
Guangdong Provincial People's Hospital
2022-2024
Shandong First Medical University
2024
Affiliated Hospital of Taishan Medical University
2024
Guangdong Academy of Medical Sciences
2022
Southern Medical University
2022
University of Tennessee Health Science Center
2017
Hebei Medical University
2011
Publications concerning the mechanism of biological activity, especially immunological C60(OH)20 nanoparticles, are relatively limited. However, structure and characteristics this carbon allotrope have been widely investigated. In paper, we demonstrated that water-soluble nanoparticles an efficient anti-tumor activity in vivo, show specific immunomodulatory effects to immune cells, such as T cells macrophages, both vivo vitro. For example, can increase production T-helper cell type 1 (Th1)...
Development of non-surgical treatment human abdominal aortic aneurysm (AAA) has clinical significance. Colchicine emerges as an effective therapeutic regimen in cardiovascular diseases. Yet, whether colchicine slows AAA growth remain controversy. Here, we demonstrated that daily intragastric administration low-dose blocked formation, prevented vascular smooth muscle cell (SMC) phenotype switching and apoptosis, inflammation both peri-aortic CaPO
Activation of peroxisome proliferator‐activated receptor (PPAR)‐γ suppresses proliferation rat pulmonary artery smooth muscle cells (PASMCs), and therefore ameliorates the development hypertension in animal models. However, molecular mechanisms underlying this effect remain largely unknown. This study addressed issue. The PPARγ agonist rosiglitazone dose‐dependently stimulated heme oxygenase (HO)‐1 expression PASMCs, 5 μ m inducing a 12.1‐fold increase HO‐1 protein level. Cells pre‐exposed...
Circular RNAs (circRNAs) are a new type of extensive non-coding that regulate the activation and progression different human diseases, including cancer. However, information on underlying mechanisms clinical significance circRNAs in lung squamous cell carcinoma (LUSC) remains scant. The expression profile 8 LUSC tissues, 9 healthy tissues were assayed using RNA sequencing (RNA-seq) techniques. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to circPVT1 its relationship...
// Zhuo Peng 1 , Longfei Pan Zequn Niu Wei Li 2 Xiaoyan Dang Lin Wan Rui Zhang and Shuanying Yang Department of Emergency Medicine, Second Affiliated Hospital, Xi’an Jiaotong University, 710004, Shaanxi Province, China Respiratory Correspondence to: Yang, email: yangshuanying66@163.com Keywords: microRNAs, lung adenocarcinoma, robust rank aggregation Received: March 20, 2017     Accepted: June 05, Published: July 18, 2017 ABSTRACT Lung adenocarcinoma (LUAD) is the...
The contribution of autophagy to cancer therapy resistance remains complex, mainly owing the discrepancy mechanisms in different therapy. However, potential autophagy-mediated icotinib have yet be elucidated.The effect was examined using a series vitro and vivo assays. results above were further verified biopsy specimens lung patients before after or gefitinib treatment.Icotinib increased ATG3, ATG5, ATG7 expression, but without affecting Beclin-1, VPS34 ATBG14 levels icotinib-resistant...
Background and objectives Both gumarontinib savolitinib have demonstrated efficacy in treating non-small-cell lung cancer (NSCLC) with tumors harboring mesenchymal–epithelial transition factor gene exon 14 (METex14) skipping. However, the comparison of their pharmacoeconomics profiles remains limited. This study aims to evaluate cost-effectiveness versus for treatment METex14 skipping NSCLC China. Methods A 3-state partitioned survival model (PSM) was developed lifetime horizon from...
Sirtuin 1 (SIRT1) is involved in the pathogenesis of allergic asthma. This study aimed to investigate whether EX‑527, a specific SIRT1 inhibitor, exerted suppressive effects on airway inflammation mice submitted ovalbumin (OVA) inhalation. In addition, this assessed such protective role was mediated by autophagy suppression though mammalian target rapamycin (mTOR) activation. Female C57BL/6 were sensitized OVA and EX‑527 (10 mg/kg) administered prior challenge. The found that reversed...
Abstract Background We aimed to explore the correlation between blood lipids (high density lipoprotein cholesterol [HDL‐C] and apolipoprotein A1 [ApoA1]) epidermal growth factor receptor (EGFR) T790M mutation, as well its predictive role in clinical efficacy progression‐free survial (PFS) advanced non‐small cell lung cancer (NSCLC) patients treated with EGFR tyrosine kinase inhibitors (EGFR‐TKI). Methods retrospectively collected information of 153 NSCLC harboring exon mutation receiving...
Epidermal growth factor receptor (EGFR) T854A is an uncommon exon 21 mutation in patients with non-small cell lung cancer (NSCLC). It was first reported samples collected after generation EGFR tyrosine kinase inhibitor (TKI) treatment as acquired resistant to EGFR-TKI. The efficacy of osimertinib, a third EGFR-TKI, these not clear.In this study, total 8932 NSCLC NGS data were retrospectively analyzed investigate the molecular characteristics and clinical outcomes mutation.Eight (0.09%) had...
Abstract Background Lung cancer accounts for the highest rate of cancer‐related diagnosis and mortality. adenocarcinoma (LUAD) is most common histopathological type. BCCIP was originally identified as a BRCA2 CDKN1A interacting protein. In different cancers, plays roles. The role in LUAD still unknown. Methods expression prognostic value analyzed using public databases, including LCE, GEPIA, TCGA, clinical specimens. Bioinformatic analysis vitro experiments were conducted to explore...
Cathepsin X (Cat X) has been identified as a member of cathepsin family. Studies have shown that Cat is involved in tumorigenesis and tumor development various cancers. The aim this study to investigate the relationship between clinicopathological prognosis levels cystatin C serum patients with lung cancer.Blood samples were collected from 84 cancer 36 healthy control subjects. determined by quantitative ELISA.Cat significantly higher than subjects (P<0.01). level was correlated pathological...
This study was to evaluate the clinical efficacy of thoracic endovascular aortic repair (TEVAR) combined with Best Medical Therapy (BMT) in acute uncomplicated type B dissection (TBAD).
Abstract Kidney cancer is the third most common malignancy of urinary system, which, kidney renal clear cell carcinoma (KIRC) accounts for vast majority. Runt-related transcription factors (RUNX) are involved in multiple cellular functions. However, diverse expression patterns and prognostic values RUNX genes remained to be elucidated. In our study, we mined DNA methylation, transcriptional survival data patients with different kinds through Oncomine, Gene Expression Profiling Interactive...
The present study reports the case of a 53-year-old male who had been suffering from coughing and presence blood-streaked sputum for >1 month. Chest computed tomography (CT) bronchoscopic brush smear were performed. patient was subsequently diagnosed with small cell lung cancer (limited stage). developed polyarthritis, abdominal pain, diarrhea purpuric rash at 14 days post thoracotomy surgery cancer. Henoch-Schönlein purpura (HSP) based on clinical symptoms. received chemotherapy steroid...