A5101468123- Bacterial biofilms and quorum sensing
- Genomics and Phylogenetic Studies
- Antibiotic Resistance in Bacteria
- Ubiquitin and proteasome pathways
- Bacterial Genetics and Biotechnology
- SARS-CoV-2 and COVID-19 Research
- Plant and Fungal Species Descriptions
- Bacteriophages and microbial interactions
- Phosphorus and nutrient management
- MicroRNA in disease regulation
- Adsorption and biosorption for pollutant removal
- Probiotics and Fermented Foods
- Plant Diversity and Evolution
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Vibrio bacteria research studies
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Herbal Medicine Research Studies
- Vector-borne infectious diseases
- Antibiotic Use and Resistance
- Insect symbiosis and bacterial influences
- Salmonella and Campylobacter epidemiology
- RNA modifications and cancer
The University of Texas MD Anderson Cancer Center
2020-2025
First Affiliated Hospital of Jiangxi Medical College
2025
Nanchang University
2025
Chengdu Medical College
2015-2023
Shanghai University
2022
Second Affiliated Hospital of Xi'an Jiaotong University
2020-2021
Shanghai Medical College of Fudan University
2010-2011
Sun Yat-sen University
2010
Heart failure (HF) is a prevalent age-related cardiovascular disease with poor prognosis in the elderly population. This study aimed to establish causal relationship between ageing and HF by conducting bidirectional Mendelian randomization (MR) analysis on epigenetic age (a marker of ageing) HF.
Circular RNAs (circRNAs) are a new type of extensive non-coding that regulate the activation and progression different human diseases, including cancer. However, information on underlying mechanisms clinical significance circRNAs in lung squamous cell carcinoma (LUSC) remains scant. The expression profile 8 LUSC tissues, 9 healthy tissues were assayed using RNA sequencing (RNA-seq) techniques. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to circPVT1 its relationship...
Recent researches indicated a down-regulation of Human beta-defensin2 (HBD2) expression in cervical cancer cells, but the mechanism and clinical significance is not clear yet. In this paper, based on data from TCGA database, bioinformatics analysis provided by UALCAN server was used. The HBD2 mRNA levels were tested with RT-qPCR cells protein concentration cell cultural supernatant assayed ELISA. When gene papillomavirus type 16 E7 oncoprotein (HPV16 E7) overexpression or knockdown, ASK1 p38...
Abstract Lung cancer is the leading cause of cancer-related death worldwide. The most common type lung KRAS mutant adenocarcinoma (KM-LUAD), which associated with smoking and inflammatory conditions. Despite various approaches recent discoveries, effective treatments for this aggressive disease remain elusive. Our previous studies along others demonstrated that expression Muc5ac, a main secretory airway mucin, high in KM-LUAD patients correlates poor prognosis. Using mouse model (CC-LR...
As an increasingly common cause of skin infections worldwide, the prevalence antibiotic-resistant Staphylococcus aureus (S. aureus) across China has not been well documented. This literature aims to study resistance profile commonly used antibiotics, including macrolides, fusidic acid (FA) and mupirocin, its relationship genetic typing in 34 S. strains, 6 methicillin-resistant (MRSA), isolated from a Chinese hospital. The MIC results showed 27 (79.4%), 1 (2.9%) (17.6%) isolates were...
The plasmid-mediated transmission of antibiotic resistance genes has been reported to be involved in the development bacteria, and poses a serious threat for success bacterial infection treatment human health worldwide. present study used 454 GS‑FLX pyrosequencing system determine ~140 kb nucleotide sequence plasmid pHS36‑NDM, which was identified Salmonella Stanley isolate from stool sample an 11‑month‑old girl at Lishui Central Hospital, China, contains New Delhi metallo‑β‑lactamase‑1...
Previously, we identified differentially expressed proteins, including ADFP, between lung adenocarcinoma (LAC) tissue and paired normal bronchioloalveolar epithelium. In this study, investigated the role of ADFP in LAC. levels serum patients with cancer benign diseases were measured by enzyme-linked immunosorbent assays (ELISA). shRNA was used to knock-down or overexpress A549 NCI-H1299 cells. The biological function its underlying mechanisms evaluated vivo vitro. highly patients, especially...
Pseudomonas aeruginosa, the main conditional pathogen causing nosocomial infection, is a gram-negative bacterium with largest genome among known bacteria. The reasons why aeruginosa prone to drug-resistant strains in clinic are: genes its and drug resistance easily induced by single antibiotic treatment. With development of high-throughput sequencing technology bioinformatics, functions various small RNAs (sRNA) are being revealed. Different sRNAs regulate gene expression binding protein or...
TFPI-2 (tissue factor pathway inhibitor-2) has recently been recognized as a new tumour suppressor gene. Low expression of this protein in several types cancers allows for enhanced growth, invasion and metastasis. To investigate the molecular mechanism responsible tumour-suppressor effects TFPI-2, we performed yeast two-hybrid analysis identified PSAP (prosaposin) TFPI-2-interacting partner. This interaction was confirmed by co-immunoprecipitation immunofluorescence. The region that...
Although most Coronavirus disease (COVID-19) patients can recover fully, the remains a significant cause of morbidity and mortality. In addition to consequences acute infection, proportion population experiences long-term adverse effects associated with SARS-CoV-2. Therefore, it is still critical comprehend virus’s characteristics how interacts its host develop effective drugs vaccines against COVID-19. SARS-CoV-2 pseudovirus, replication-deficient recombinant glycoprotein chimeric viral...
Q fever is a zoonotic disease caused by Coxiella burnetii. Most patients have non-specific symptoms at onset. In addition, routine diagnostic tests for C. burnetii are not sensitive, and the bacterium cannot grow in general culture medium. The diagnosis of therefore poses challenge. This case study describes man with clear history tick bite who had recurrent fever, pneumonia, liver damage. Routine bacterial cultures failed to clarify pathogeny, but laboratory imaging data suggested...
Leukemia is a common blood cancer, whose treatment usually necessitates chemo/radiotherapy and bone marrow transplant. Hence, safer more effective options are urgently needed. Mylabris, the dried body of blister beetles, has been used extensively in traditional Chinese medicine. This study applied bioinformatics systematic pharmacology to investigate mechanism action mylabris leukemia. Five components 35 corresponding target proteins were identified by screening TCMSP database; whereas 776...
TOA02 is a genetically modified oncolytic adenovirus that contains human granulocyte macrophage colony-stimulating factor (hGM-CSF). It has been verified in vitro can specifically replicate tumor cells possess high telomerase reverse transcriptase activity and Rb pathway deficiency. However, the replication specificity, hGM-CSF expression, toxicity of vivo are still unknown. Therefore, biosafety remains critical issue before its potential clinical use. In this study, viral expression levels...
This study aimed to evaluate the potential mechanism by which Monocyte locomotion inhibitory factor (MLIF) improves outcome of ischemic stroke (IS) inflammatory injury.Potential MLIF-related targets were predicted using Swiss TargetPrediction and PharmMapper, while IS-related found from GeneCards, PharmGKB, Therapeutic Target Database (TTD). After obtaining intersection these two datasets, Search Tool for Retrieval Interacting Genes/Protein (STRING11.0) database was used analyze...