A5090470678- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Synthesis and properties of polymers
- Silicone and Siloxane Chemistry
- Epoxy Resin Curing Processes
- Neuroscience and Neuropharmacology Research
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoplatforms for cancer theranostics
- Immune Response and Inflammation
- Photoacoustic and Ultrasonic Imaging
- Photodynamic Therapy Research Studies
- Financial Risk and Volatility Modeling
- Market Dynamics and Volatility
- Advancements in Battery Materials
- Financial Markets and Investment Strategies
- Advanced Battery Technologies Research
- Acupuncture Treatment Research Studies
- Ion Transport and Channel Regulation
- Digital Platforms and Economics
- Apelin-related biomedical research
- Fire dynamics and safety research
- Digital Economy and Work Transformation
- Advanced Battery Materials and Technologies
- Medicinal Plants and Bioactive Compounds
Northwestern Polytechnical University
2020-2025
Xi'an Technological University
2025
University of Science and Technology Beijing
2017-2022
Heilongjiang Academy of Sciences
2017-2020
Kutztown University
2010-2019
Harbin University
2018
National Defense Medical Center
2015
University of Virginia
2008-2015
Beth Israel Deaconess Medical Center
2015
Harvard University
2015
Preexposure of brain to isoflurane, a commonly used anesthetic, induces ischemic tolerance. This phenomenon is called isoflurane preconditioning. However, it not known whether application after ischemia provides neuroprotection.Corticostriatal slices (400 microm) freshly prepared from adult male Sprague-Dawley rats were subjected 15-min oxygen-glucose deprivation (OGD; simulate in vitro). Isoflurane was applied OGD. Brain harvested 2 h OGD for measuring 2,3,5-triphenyltetrazolium chloride...
Obesity is a major health issue. started from teenagers has become concern in recent years. Intermittent fasting increases the life span. However, it not known whether obesity and intermittent affect brain functions structures before aging. Here, we subjected 7-week old CD-1 wild type male mice to (alternate-day) or high fat diet (45% caloric supplied by fat) for 11 months. Mice on had better learning memory assessed Barnes maze fear conditioning, thicker CA1 pyramidal cell layer, higher...
In this study, we investigated the development of endoplasmic reticulum (ER) stress after traumatic brain injury (TBI) and efficacy post-TBI administration docosahexaenoic acid (DHA) in reducing ER stress. TBI was induced by cortical contusion Sprague-Dawley rats. Either DHA (16 mg/kg DMSO) or vehicle DMSO (1 ml/kg) administered intraperitoneally at 5 min TBI, followed a daily dose for 3–21 d. triggered sustained expression marker proteins including phosphorylated eukaryotic initiation...
WNK kinases, including WNK3, and the associated downstream Ste20/SPS1-related proline-alanine-rich protein kinase (SPAK) oxidative stress responsive 1 (OSR1) comprise an important signaling cascade that regulates cation-chloride cotransporters. Ischemia-induced stimulation of bumetanide-sensitive Na(+)-K(+)-Cl(-) cotransporter (NKCC1) plays role in pathophysiology experimental stroke, but mechanism its regulation this context is unknown. Here, we investigated WNK3-SPAK/OSR1 pathway as a...
Background Preconditioning the brain with relatively safe drugs seems to be a viable option reduce ischemic injury. The authors and others have shown that volatile anesthetic isoflurane can precondition against ischemia. Here, determine whether preconditioning improves long-term neurologic outcome after Methods Six-day-old rats were exposed 1.5% for 30 min at 24 h before hypoxia-ischemia was induced by left common carotid arterial ligation then exposure 8% oxygen 2 h. neuropathology, motor...
Postoperative cognitive decline is a clinical syndrome. Volatile anesthetics are commonly used during surgery. It conceivable that volatile may contribute to postoperative decline. Isoflurane can impair functions of animals under certain conditions. However, the mechanisms for this impairment not clear. Here, male 18-month old Fisher 344 rats or 10-week mice were exposed 1.2 1.4% isoflurane 2 h. Our studies showed impaired in Barnes maze. Isoflurane-exposed had reduced freezing behavior...
Excitatory amino-acid transporters (EAATs) transport glutamate into cells under physiologic conditions. transporter type 3 (EAAT3) is the major neuronal EAAT and also uptakes cysteine, rate-limiting substrate for synthesis of glutathione. Thus, we hypothesize that EAAT3 contributes to providing brain ischemic tolerance. Male 8-week-old knockout mice on CD-1 mouse gene background wild-type were subjected right middle cerebral artery occlusion 90 minutes. Their infarct volumes, neurologic...
To enhance the performance of combustors in micro thermophotovoltaic systems, this study employs numerical simulations to investigate a planar microscale combustor featuring counter-flow flame configuration. The analysis begins with an evaluation effects (1) equivalence ratio Φ and (2) inlet flow rate Vi on key thermal combustion parameters, including average temperature main wall (T¯w), non-uniformity (R¯Tw) radiation efficiency (ηr). findings indicate that increasing causes these...
Background Isoflurane pretreatment can induce protection against lipopolysaccharide and interferon gamma (IFNgamma)-induced injury activation of mouse microglial cells. This study's goal was to determine whether delayed isoflurane treatment is protective. Methods Mouse cells were exposed various concentrations for 1 h immediately after the initiation (10 or 1000 ng/ml) IFNgamma U/ml) stimulation 2% at times stimulation. Nitrite production, lactate dehydrogenase release, cell viability...
Neuroinflammation is an important pathological process for almost all acquired neurological diseases. Microglial cells play a critical role in neuroinflammation. We determined whether lidocaine, local anesthetic with anti-inflammatory property, protected microglial and attenuated cytokine production from activated cells.Mouse cultures were incubated or without 1 μg/mL lipopolysaccharide 10 U/mL interferon γ (IFNγ) 24 hours the presence absence of lidocaine hour started at 2, 3, 4 after onset...
Two new monomers were prepared by the reaction of 2-allylphenol and 4,4′-biphenyldicarbonyl chloride under different conditions. The characterized Fourier transform infrared spectroscopy nuclear magnetic resonance spectroscopy. curing processes N, N-4,4′-bismaleimidodiphenylmethyene with 4,4′-bis(2-allylphenyl) biphenyldicarbonylate (BABC) 4,4′-bis(2-propenylphenyl benzoate) ether (BPBE) studied rheological analysis differential scanning calorimetry. Melting points two monomers, BABC BPBE,...