A5022554492- Analytical chemistry methods development
- Mass Spectrometry Techniques and Applications
- Graphene and Nanomaterials Applications
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- Biosensors and Analytical Detection
- Pharmacological Effects and Toxicity Studies
- Ion-surface interactions and analysis
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Granular flow and fluidized beds
- Mercury impact and mitigation studies
- Electrochemical Analysis and Applications
- Cyclone Separators and Fluid Dynamics
- Gut microbiota and health
- Air Quality and Health Impacts
- Nanocluster Synthesis and Applications
- Click Chemistry and Applications
- Metabolomics and Mass Spectrometry Studies
- Heavy Metal Exposure and Toxicity
- Alzheimer's disease research and treatments
- Forensic and Genetic Research
- Medical and Biological Ozone Research
- Particle Dynamics in Fluid Flows
China University of Mining and Technology
2023-2024
Institute of High Energy Physics
2015-2024
Chinese Academy of Sciences
2015-2024
University of Hong Kong
2020-2023
University of Chinese Academy of Sciences
2019
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2014
Nanomaterials Research (United States)
2014
Jingdong (China)
2014
Zhengzhou University
2011
Abstract Carbon nanotubes (CNTs) hold promise in manufacturing, environmental, and biomedical applications, as well food agricultural industries. Previous observations have shown that CNTs antimicrobial activity; however, the impact of to human gut microbes has not been investigated. Here, antibacterial activity against commonly encountered digestion system— L. acidophilus , B. adolescentis E. coli faecalis S. aureus —are evaluated. The bacteria studied include pathogenic non‐pathogenic,...
Abstract Background To effectively applied nanomaterials (NMs) in medicine, one of the top priorities is to address a better understanding possible sub-organ transfer, clearance routes, and potential toxicity NMs liver kidney. Results Here we explored how surface chemistry polyethylene glycol (PEG), chitosan (CS), polyethylenimine (PEI) capped gold nanoparticles (GNPs) governs their biodistribution, profiles kidney after intravenous injection mice. The PEG-GNPs maintained dispersion...
Single cell analysis has become an important field of research in recent years reflecting the heterogeneity cellular responses biological systems. Here, we demonstrate a new method, based on laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS), which can quantify situ gold nanoparticles (Au NPs) single cells. Dried residues picoliter droplets ejected by commercial inkjet printer were used to simulate matrix-matched calibration standards. The cells exposed 100 nM NIST Au NPs...
Novel single cell techniques are attracting growing interest for clinical applications, because they can elucidate the cellular diversity and heterogeneity instead of average masked by bulk measurements. Herein, time-resolved ICP-MS determination essential mineral elements in cells has been developed is used to analyze contents distribution patterns Fe, Cu, Zn, Mn, P S two types cancer (HeLa A549) one type normal (16HBE). The results show that there obvious differences among three cells....
With the increasing production and widespread potential applications of single-walled carbon nanotubes (SWCNTs), possible impacts oral administration SWCNTs on gastrointestinal tract at currently occupational exposure limits biomedical should be concerned. To address concerns, mice are orally administrated doses 0.05, 0.5, 2.5 mg kg-1 body weight per day for 7 d. The investigation shows that SWCNT treatment had promoted intestinal injuries acute dose day, including increase histological...
Vertical hydraulic transport of particles with wide particle size distributions is a crucial process for coal physical fluidized mining. In the present study, an improved semi-resolved computational fluid dynamics (CFD)-discrete element method was developed to simulate flows distributions. this model, CFD cells allocated volume and momentum source term were defined as dependent domain influential domain, respectively. On basis, two-way expansion one-way adopted liquid–solid simulation coarse...
We report for the first time seeing and counting integrin α(IIb)β3 on a single-cell level. The proposed method is based using of Au cluster probe. With fluorescent property Au24 specific targeting ability peptide, our probe can directly visualize membrane human erythroleukemia cells (HEL) via confocal microscopy. On basis accurate formula (Au24Peptide8), number be precisely counted by quantifying gold content single HEL cell laser ablation inductively coupled plasma mass spectrometry. Our...
The impact of the gut microbiota on human health is widely perceived as most exciting advancement in biomedicine. has been known to play a crucial role defining states and diseases, thus becomes potential new territory for drug targeting. Herein, graphene oxide (GO) interaction with five common bacteria, B. adolescentis, L. acidophilus, E. coli, faecalis, S. aureus, was studied. It shown that, bacterial media, GO sheets were able form effective, anaerobic membrane scaffolds that enhanced...
Laser ablation–inductively coupled plasma–mass spectrometry (LA–ICP–MS) is an emerging method for the analysis of metal nanoparticles (NPs) in single cells. However, two main obstacles, low analytical throughput and lack commercial reference materials, need to be overcome. In this work, we demonstrated principles a new approach termed "single-cell isotope dilution analysis" (SCIDA) remove obstacles. For proof concept, macrophage cells were chosen as model study uptake silver NPs (AgNPs) at...
Nonalcoholic fatty liver disease (NAFLD) is the leading hepatic manifestation of metabolic syndrome worldwide, and clinically accompanied by iron overload. As increasing application oxide nanoparticles (IONPs) on imaging diagnosis in NAFLD, potential effect mechanism IONPs NAFLD should be well studied. Here, we demonstrate that carboxyl-modified (COOH-IONPs) amino-coated (NH2-IONPs) exhibit no significant toxicity normal mice at clinical injection dose, but aggravate SREBP-1c-mediated de...
Abstract Background Renal excretion is one of the major routes nanomaterial elimination from body. Many previous studies have found that graphene oxide nanosheets are excreted in bulk through kidneys. However, how lateral size affects GO disposition kidneys including glomerular filtration, active tubular secretion and reabsorption still unknown. Results The thin, two-dimensional (GOs) was observed to excrete urine kidneys, but dimension GOs their renal clearance pathway injury. s -GOs could...
Silver nanoparticles in single cells trapped by a microwell array were quantified laser ablation-ICP-MS.
Single-particle inductively coupled plasma-mass spectrometry (SP-ICP-MS) has emerged as an important tool for the characterization of inorganic nanoparticles (NPs) in environment. Although most SP-ICP-MS applications rely on quadrupole ICP-MS (ICP-QMS), it is limited by slow scanning speed quadrupole. Recent advancements instrumentation have led to development plasma time-of-flight mass (ICP-TOF-MS) which offers a viable solution. In this review, we discuss recent advances and methodology...
Nanocarriers have been researched comprehensively for the development of novel boron-containing agents in boron neutron capture therapy (BNCT). We designed and synthesized a multifunctional mesoporous silica nanoparticle (MSN)-based agent. The latter was coated with lipid bilayer (LB) decorated SP94 peptide (SFSIIHTPILPL) on surface as SP94-LB@BA-MSN. incorporated boric acid (BA) into hydrophobic mesopores, an LB, modified LB. SP94-LB@BA-MSN enhanced nano interface tumor-targeting ability...