A5077220702- Immunotherapy and Immune Responses
- Animal Virus Infections Studies
- T-cell and B-cell Immunology
- Chemokine receptors and signaling
- Virus-based gene therapy research
- Bone Metabolism and Diseases
- High-Energy Particle Collisions Research
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Spinal Cord Injury Research
- Particle physics theoretical and experimental studies
- Veterinary medicine and infectious diseases
- Cancer-related molecular mechanisms research
- Animal Nutrition and Physiology
- Quantum Chromodynamics and Particle Interactions
- Coccidia and coccidiosis research
- Neuroinflammation and Neurodegeneration Mechanisms
- Respiratory viral infections research
- Crystallography and molecular interactions
- Viral-associated cancers and disorders
- Air Quality and Health Impacts
- HIV Research and Treatment
- vaccines and immunoinformatics approaches
- Pancreatic function and diabetes
Shanghai University of Traditional Chinese Medicine
2025
Fujian Academy of Agricultural Sciences
2021-2024
China Animal Disease Control Center
2021-2024
Northern Jiangsu People's Hospital
2022-2024
Nanjing University
2024
Army Medical University
2024
Nanjing Drum Tower Hospital
2024
Shandong First Medical University
2021-2023
Jinan Central Hospital
2020-2023
Shandong University
2004-2023
Autoantibodies to histidyl–tRNA synthetase (HisRS) or alanyl–, asparaginyl–, glycyl–, isoleucyl–, threonyl–tRNA occur in ∼25% of patients with polymyositis dermatomyositis. We tested the ability several aminoacyl–tRNA synthetases induce leukocyte migration. HisRS induced CD4+ and CD8+ lymphocytes, interleukin (IL)-2–activated monocytes, immature dendritic cells (iDCs) migrate, but not neutrophils, mature DCs, unstimulated monocytes. An NH2-terminal domain, 1–48 HisRS, was chemotactic for...
Infection due to 2009 pandemic H1N1 influenza A virus (A[H1N1]pdm09) is commonly manifested as mild infection but occasionally severe pneumonia. We hypothesized that host genetic variations may contribute disease severity. An initially small-scale genome-wide association study guided the selection of CD55 single-nucleotide polymorphisms in 425 Chinese patients with (n = 177) or 248) disease. Carriers rs2564978 genotype T/T were significantly associated (odds ratio, 1.75; P .011) under a...
The immunostimulatory outcome of the interactions many pathogens with dendritic cells (DCs) has been well characterized. There are fewer examples similar between DCs and self-molecules, especially abnormal self-proteins such as tumor Ags, their effects on DC function immune response. We show that human epithelial cell Ag MUC1 mucin is recognized in its aberrantly glycosylated form by immature myeloid both a chemoattractant (through polypeptide core) maturation activation signal carbohydrate...
Reactive astrocytes are implicated in traumatic spinal cord injury (TSCI). Interestingly, naïve can easily transform into neurotoxic reactive (A1s) with inflammatory stimulation. Previous studies demonstrated that microRNA(miR)-21a-5p was up-regulated tissue after TSCI; however, it is not clear whether this affected astrocyte polarization. Here, we aim to detect the effects of miR-21a-5p on induction A1 formation and underlying mechanisms. Our study found expression significantly increased...
Abstract Aim To investigate the effect of apigenin on fibrous scar formation after mouse spinal cord injury (SCI). Methods The pneumatic impactor strike method was used to establish an SCI model. Mice were intraperitoneally injected with 5 mg/kg or 20 daily for 28 days SCI. Basso Mouse Scale (BMS) score, hematoxylin–eosin staining, and immunohistochemical staining assess motor function recovery. Western blotting qRT‐PCR detect expression fibrosis‐related parameters in tissue homogenates....
Osteomyelitis (OM) is an inflammatory condition of bone characterized by cortical devascularization and necrosis. Dysregulation remodelling triggered OM. Bone precisely coordinated resorption formation via a reversal phase. However, the cellular molecular mechanisms underlying failure after osteomyelitis remain elusive. To elucidate mechanism healing osteomyelitis, we employed single-cell RNA sequencing (scRNA-seq) to depict atlas human in normal, infected reconstructed states....
Abstract Osteoporosis (OP) is a common and fracture-prone skeletal disease characterized by deteriorated trabecular microstructure pathologically involving various forms of regulated bone cell death. However, the exact role, cellular nature regulatory mechanisms ferroptosis in OP are not fully understood. Here, we reported that femurs from ovariectomized (Ovx) mice exhibited pronounced iron deposition, ferroptosis, transcriptional suppression key anti-ferroptotic factor GPX4 (glutathione...
The influence of steam and minerals on Cr transformation during oxy-coal combustion has been examined in a drop tube furnace at 1273 K. An extra 500 ppmv HCl 1000 SO2 were also added to flue gas examine the competition H2O, HCl, behaviors upon recirculation impurities gas. It was found that CaO Fe2O3 exhibited high capability capturing Cr-bearing vapors compared limestone kaolin. Changing air obviously weakened role CaO, whereas it promoted reaction between vapors. existence H2O facilitated...
Background. Lymphatic filariasis is a chronic human parasitic disease in which the parasites repeatedly provoke acute and inflammatory reactions host bloodstream lymphatics. Excretory-secretory products derived from filariae are believed to play an important role development of associated immunologic conditions; however, specific mechanisms involved these changes not well understood. Recently, cytoplasmic aminoacyl-transfer (t) RNA synthetases, autoantigens idiopathic myopathies, were shown...
The shear viscosity to entropy density ratio, $\ensuremath{\eta}/s$, characterizes how perfect a fluid is. We calculate the leading order $\ensuremath{\eta}/s$ of gluon plasma in perturbation using kinetic theory. contribution only involves elastic $gg\ensuremath{\leftrightarrow}gg$ (22) process and inelastic $gg\ensuremath{\leftrightarrow}ggg$ (23) process. hard-thermal-loop (HTL) treatment is used for 22 matrix element, while exact element vacuum supplemented by Debye mass insertion 23...
Subunit a plays key role in coupling H+ transport to rotations of the subunit c-ring F1Fo ATP synthase. In Escherichia coli, binding and release occur at Asp-61 middle second transmembrane helix (TMH) Fo c. Based upon Ag+ sensitivity Cys substituted into a, are thought reach via aqueous pathways mapping surfaces TMH 2–5. this study we have extended characterization most Ag+-sensitive residues with cysteine reactive methanethiosulfonate (MTS) reagents Cd2+. The effect these on ATPase-coupled...
We compute sea quark Sivers distribution within color glass condensate(CGC) framework. It has been found that up to the leading logarithm accuracy, collinear twist-3 approach and CGC calculation yield same result for in dilute limit. further verify transverse momentum dependent factorization is consistent with treatment at small $x$ case of spin asymmetry open charm production semi-inclusive deeply inelastic scattering process an overlap kinematical region.
The leading order contribution to the shear and bulk viscosities, \eta \zeta, of a gluon plasma in perturbative QCD includes gg -> (22) process, <-> ggg (23) process multiple scattering processes known as Landau-Pomeranchuk-Migdal (LPM) effect. Complete computations for \zeta were obtained by Arnold, Moore Yaffe (AMY) Dogan (ADM), respectively, with inelastic computed an effective g splitting. We study how complementary calculations 22 23 simple treatment model LPM effect compare results AMY...
TLR agonists have been suggested to directly impact Tregs, thereby enhancing or reversing their suppressive function. Here, in order select leading potent effector T-cell responses, while minimizing Treg inhibitory function, we used a model antigen, covalently linked an inert delivery system, combined with large panel of agonists, for the immunization mice attenuated/depleted intact subset. We observed that negative modulation CD4(+) T cells exerted by Tregs cannot be circumvented, whatever...
Utilising rabbit corneal endothelial cells (CEC) in three different paradigms, two human FGF1 derivatives (TTHX1001 and TTHX1114), engineered to exhibit greater stability, were tested as proliferative agents. Primary CECs mouse NIH 3T3 treated with the showed equivalent EC50 ranges (3.3–24 vs.1.9–16. ng/mL) and, organ culture, chemically lesioned corneas regained half of lost layer days after treatment compared controls. In vivo, following cryolesioning, CEC monolayer, judged by specular...