A5102711177- Microbial Inactivation Methods
- Endometrial and Cervical Cancer Treatments
- Microfluidic and Bio-sensing Technologies
- Ovarian cancer diagnosis and treatment
- Semiconductor Lasers and Optical Devices
- Photonic and Optical Devices
- Uterine Myomas and Treatments
- Ultrasound and Cavitation Phenomena
- Intraperitoneal and Appendiceal Malignancies
- Cervical Cancer and HPV Research
- Optical Network Technologies
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- PARP inhibition in cancer therapy
- Management of metastatic bone disease
- Endometriosis Research and Treatment
- Minimally Invasive Surgical Techniques
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
- Cancer Risks and Factors
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Ultrasound and Hyperthermia Applications
- Soft tissue tumors and treatment
- Cancer, Hypoxia, and Metabolism
The Affiliated Yongchuan Hospital of Chongqing Medical University
2012-2024
Chongqing Medical University
2012-2024
Nanjing University of Chinese Medicine
2023
Shanghai Institute of Materia Medica
2023
Chinese Academy of Sciences
2023
Chongqing University
2003-2013
Wan Fang Hospital
2013
Royal Liverpool University Hospital
2010
University of Liverpool
2010
Xingtai University
2005
This phase III trial aimed to explore the efficacy and safety of fuzuloparib (formerly fluzoparib) versus placebo as a maintenance treatment after response second- or later-line platinum-based chemotherapy in patients with high-grade, platinum-sensitive, recurrent ovarian cancer.Patients cancer previously treated at least two regimens were assigned (2:1) receive (150 mg, twice daily) matching for 28-day cycles. The primary end points progression-free survival (PFS) assessed by blinded...
Abstract Background Among the common preventable cancers of women, cervical cancer has highest morbidity. It is curable if detected at an early stage. However, reliable diagnostic and prognostic markers, which relate to physiologic pathologic regulation cancer, are not available. In this study, one such potential marker, ZBTB28, was evaluated for its usefulness in assessment. Methods Public database analysis, reverse-transcription polymerase chain reaction (PCR), methylation-specific PCR...
<h3>Introduction/Background</h3> Disitamab Vedotin (RC48) is a HER2-targeted ADC. A phase II, open-label, multicenter basket design study (NCT04965519) currently underway to evaluate the effectiveness and safety of RC48 monotherapy in treatment HER2-expressing gynecologic malignancies. <h3>Methodology</h3> The cervical cancer cohort includes patients with recurrent or metastatic who have progressed on at least 1L anti-tumor therapy HER2 IHC ≥1+. regimen consists administered dose 2 mg/kg...
Preoperative neoadjuvant chemotherapy (NACT) has been widely used in developing countries for the treatment of patients with International Federation Gynecology and Obstetrics (FIGO) stages IB3 IIA2 cervical cancer. However, effectiveness NACT options NACT-insensitive have concerning. This study will assess prognostic differences between primary surgery (PST), determine factors associated prognosis, explore better adjuvant modalities patients.
We studied the influence of various parameters high-frequency nanosecond pulse bursts on strength rabbit muscle contractions. Ten unipolar with field intensities E (1 kV/cm, 4 and 8 kV/cm), intraburst frequencies f (10 kHz, 100 1 MHz), numbers N (1, 10, 100) were applied using a pair plate electrodes to surface skin rabbits’ biceps femoris, acceleration signal contraction near electrode was measured 3-axis sensor. A time- frequency-domain analysis signals showed that peak value increases...
This paper studies the apoptosis of human ovarian carcinoma cell Line (SKOV3) induced by nanosecond pulsed electric field (10kV/cm, 100ns, 1 Hz) and its effect on intracellular calcium concentration ([Ca2+]i). These cells were doubly marked Annexin V-FITC/PI, rate was analyzed with flow cytometry. After AO/EB staining morphological changes observed under fluorescent microscope, their ultrastructural scanning electron microscope (SEM). With Fluo-3/AM as marker, laser confocal (LSCM) used to...
In order to get in vivo evidences of nanosecond pulsed electric fields (nsPEF) for skin tumor treatment, models 10 female BALB/c nude mice were established by inoculating them with human melanoma cells A375. These randomly divided into treated group (exposed nsPEF intensity 20 kV/cm and duration 300 ns) control equally. Five days post-nsPEF growth the was effectively inhibited (P < 0.01 compared that group), typical apoptotic characteristics (DNA damage fragmentation) observed terminal...
Abstract Using 70 U/ml or 35 as CA125 routine abnormal threshold may result in omissions the relapse detection of Ovarian cancer (OvCa). This study aimed to clarify association between a biochemical (only elevation CA125) and an image-identified predict relapsed lesions better. 162 patients who achieved complete clinical response were enrolled from women diagnosed with stage I-IV serous ovarian, tubal, peritoneal cancers January 2013 June 2019 at our center. The level 2 × nadir was defined...
Molecular chaperones are key components of protein quality control system, which plays an essential role in controlling homeostasis. Aha1 has been identified as a co-chaperone Hsp90 known to strongly accelerate Hsp90's ATPase activity. Meanwhile, it is reported that could also act autonomous chaperone and protect stressed or disordered proteins from aggregation. Here, this article, series vitro experiments were conducted verify whether non-Hsp90-dependent holdase activity elucidate the...
Conflicting data have been published regarding the oncologic appropriateness of minimally invasive surgery (MIS) in treatment cervical cancer. The purpose present study was to investigate whether our experience early cancer using a robotic surgical approach safe and oncologically effective.The 557 patients with treated by were retrospectively collected, including perioperative survival outcomes. Tumor stage based on International Federation Gynecology Obstetrics (FIGO 2009). disease-free...
Recent studies have shown that minimally invasive surgery (MIS) is associated with a higher recurrence rate in patients early-stage cervical cancer. In this study, we aim to report the survival outcomes of cancer who received MIS, performed single center by same surgeon.Eligible participants included stage IA1 lymphovascular space invasion (LVSI+), IA2, and IB1. The surgeries were carried out surgeon 137 evaluated retrospectively.The median follow-up time for was 53 (25-94) months, five-year...
In order to study the apoptosis-induction effects of exponential decay nanosecond pulsed electric fields (EDnsPEF) <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in vivo</i> , tumor models in 20 female BALB/c nude mice were established by inoculating them with human melanoma cells A375. These randomly divided into treated group (exposed EDnsPEF intensity kV/cm and duration 300 ns) control equally. Twenty days later, growth was effectively...
Tumor cell apoptosis by using nanosecond pulsed electric fields (nsPEF) has a great potential in clinical tumor treatment. It is difficult to find the appropriate parameters of nsPEF which can induce substantial apoptotic cells because selectivity between and pulse number duration. To obtain optimum achieve large proportion cells, with different (Electric field intensity 45 kV/cm; durations are 50, 100 200 ns respectively; numbers 10, 30, 60 80, repetition frequency 1 Hz) were performed on...
Multi-walled carbon nanotubes with excellent electrical properties and high aspect ratios can reduce the field strength required to kill cancer cells in vitro nanosecond pulsed electric fields. For first time, this article systematically comprehensively evaluates effects of various parameters fields combined multi-walled on cell viability. The strength, E (2-10 kV/cm); pulse width, τ (100-500 ns); number, N (5-260) viability A375 human skin presence are studied using Cell Counting Kit 8...
Rationale: Pelvic exenteration is considered a method to treat central recurrent or persistent gynecologic malignancy after the initial therapy. The postoperative survival rate has been greatly increased by improvement in surgical technology and perioperative management. Yet various complications are still impacting quality of life. New technologies such as robotic surgery system made it possible approach radical resection using minimally invasive method. Patient concerns: patient...
High-intensity nanosecond pulsed electric fields (nsPEFs) are a novel treatment with promising applications for cell stimulation and tissue ablation, many research studies have shown that gold nanorods (GNRs) high-conductivity nanomaterials can enhance electroporation biomedical applications. In addition, the folic acid (FA) receptor has been demonstrated as valuable therapeutic target is highly expressed in variety of cancers. To reduce field strength required to treat tumors by nsPEFs,...
A recent prospective randomized study demonstrated that minimally invasive surgery (MIS) was inferior to open in disease survival early-stage cervical cancer. Our aim investigate whether there were benefits of preoperative conization prior MIS for cancer.We retrospectively analyzed patients who eventually underwent definitive with stage IA2 IB1 (no >2 cm) squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinoma. Preoperatively, the separated into 2 groups: one managed other...