A5100323576- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Nerve injury and regeneration
- Restless Legs Syndrome Research
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Rheumatoid Arthritis Research and Therapies
- Botulinum Toxin and Related Neurological Disorders
- Functional Brain Connectivity Studies
- Nuclear Receptors and Signaling
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA Research and Splicing
- Cytokine Signaling Pathways and Interactions
- Mechanical Circulatory Support Devices
- Autophagy in Disease and Therapy
- Inflammasome and immune disorders
- Neuroblastoma Research and Treatments
- Spinal Cord Injury Research
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Radiomics and Machine Learning in Medical Imaging
- Tissue Engineering and Regenerative Medicine
- Spondyloarthritis Studies and Treatments
- Neurogenesis and neuroplasticity mechanisms
Changzhou No.2 People's Hospital
2012-2024
Nanjing Medical University
2014-2024
Capital Medical University
2014-2024
Thomas Jefferson University
2018-2024
Weatherford College
2021-2024
Anhui Medical University
2024
University of Georgia
2024
Tsinghua University
2022-2023
Jiangsu Province Hospital
2012-2023
Affiliated Hospital of Shaanxi University of Chinese Medicine
2023
Objectives: Emergence delirium (ED) is a common neurologic complication that can not only distress children and their families in the early postanesthetic period, but also have adverse effects on long-term. This study aimed to investigate of single-dose dexmedetomidine ED with sevoflurane anesthesia observe postoperative behavioral changes through long-term follow-up. Methods: Patients aged 2–7 years, American Society Anesthesiologists class (ASA) I or II, scheduled for tonsillectomy without...
<h3>Background:</h3> Depression and stress are major risk factors for suicidal behaviour, some studies show abnormalities of proinflammatory cytokines in the serum cerebrospinal fluid (CSF) depressed patients. However, it is not clear if similar present brain <h3>Methods:</h3> We therefore determined mRNA (using real-time polymerase chain reaction) protein enzyme-linked immunosorbent assay Western Blot) expression levels interleukin (IL)-1β, IL-6, tumour necrosis factor (TNF)-α, lymphotoxin...
Dysfunction of macroautophagy/autophagy in macrophages contributes to atherosclerosis. Impaired autophagy-lysosomal degradation system leads lipid accumulation, facilitating atherosclerotic plaque. ATG14 is an essential regulator for the fusion autophagosomes with lysosomes. Whether plays a role macrophage autophagy dysfunction atherosclerosis unknown. To investigate effects on autophagy, human plaque, apoe−/- mice and cultured mouse were evaluated. Overexpression by adenovirus was used...
Repair of spinal cord injury (SCI) depends on microenvironment improvement and the reconnection between injured axons regenerated neurons. Here, we fabricate a GelMA-MXene hydrogel nerve conduit with electrical conductivity internal-facing longitudinal grooves explore its function in SCI repair. It is found that resultant grooved could effectively promote neural stem cells (NSCs) adhesion, directed proliferation differentiation vitro. Additionally, when loaded NSCs (GMN) implanted into site,...
MicroRNAs (miRNAs) are small, noncoding regulatory molecules. They involved in many essential biological processes and act by suppressing gene expression. The present work reports an integrative analysis of miRNA-mRNA miRNA-miRNA interactions their patterns using high-throughput miRNA mRNA datasets. Aberrantly expressed profiles were obtained based on fold change analysis, qRT-PCR was used for further validation deregulated miRNAs. miRNAs target mRNAs found to show various expression...
Abstract Aims Inadequate autophagy contributed to endothelial dysfunction in diabetic patients. We aimed investigate the relationship between inadequate and cells (ECs) apoptosis diabetes its underlying mechanism. Methods results Aortic intima ECs were isolated from Cultured human aortic (HAECs) stimulated with advanced glycation end products (AGEs). The expression of apoptosis-related proteins determined by western blotting. Autophagosomes observed electron microscopy. fusion autophagosome...
Parkinson's disease (PD) is the second most common neurodegenerative disorder. Dopamine (DA) neurons in substantia nigra pars compacta, which have axonal projections to dorsal striatum (dSTR), degenerate PD. In contrast, DA ventral tegmental area, with striatum, including nucleus accumbens (NAcc) shell, are largely spared. This study aims uncover relative contributions of glycolysis and oxidative phosphorylation (OxPhos) release striatum. We measured evoked mouse striatal brain slices using...
Glial cell line-derived neurotrophic factor (GDNF) has been shown to protect and restore dopamine (DA) neurons in injury models is being evaluated for the treatment of Parkinson's disease. Nevertheless, little known its physiological role. We have that GDNF suppresses apoptosis DA substantia nigra (SN) postnatally both vitro during their first phase natural death vivo . Furthermore, intrastriatal injection neutralizing antibodies augments death, suggesting endogenous plays a role as...
Background Musculoskeletal pain is commonly experienced in patients with Parkinson's disease (PD). Few studies have investigated the clinical characteristics and risk factors associated musculoskeletal pain. Objectives To investigate distribution, characteristics, a large sample of PD. Methods We enrolled 452 from two clinics used standardized questionnaire to collect demographic information. was diagnosed based on Ford Classification System, severity assessed numeric rating scale (NRS)....
We conducted this study is to investigate the correlation between stereopsis dysfunction and color perception, as well whether impairment associated with motor in patients Parkinson's disease (PD).Our present included 45 PD 50 non-PD control attending Movement Disorder Center at Xuanwu Hospital Capital Medical University Beijing from July 2011 November 2011. Neurologic evaluations visual function assessments were conducted, results two groups of compared.We found that total error scores...