A5042238696- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Parkinson's Disease Mechanisms and Treatments
- Anesthesia and Pain Management
- Spine and Intervertebral Disc Pathology
- Transplantation: Methods and Outcomes
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Anesthesia and Neurotoxicity Research
- Cardiac, Anesthesia and Surgical Outcomes
- Mesenchymal stem cell research
- Neurogenesis and neuroplasticity mechanisms
- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- Breast Cancer Treatment Studies
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Hip and Femur Fractures
- Immune Cell Function and Interaction
- Caveolin-1 and cellular processes
- Breast Lesions and Carcinomas
- Cancer, Stress, Anesthesia, and Immune Response
- Intensive Care Unit Cognitive Disorders
- Anesthesia and Sedative Agents
- Infectious Diseases and Tuberculosis
Yixing People's Hospital
2017-2025
Jiangsu University
2015-2025
Tianjin First Center Hospital
2016-2025
Tianjin Medical University
2016-2025
First Hospital of Jiaxing
2015-2025
Jiaxing University
2019-2025
Dalian Medical University
2015-2025
First Affiliated Hospital of Dalian Medical University
2015-2025
Army Medical University
2020-2025
Tianjin Hospital
2011-2024
Abstract Increasing evidence suggests that microglial activation is strongly linked to the initiation and progression of Parkinson’s disease. Cell-to-cell propagation α-synuclein pathology a highlighted feature disease, focus such research has been primarily on neurons. However, recent studies as well data contained herein suggest microglia, primary phagocytes in brain, play direct role spread pathology. Recent revealed plasma exosomes derived from disease patients (PD-EXO) carry...
Circadian disturbance is a common nonmotor complaint in Parkinson's disease (PD). The molecular basis underlying circadian rhythm PD poorly understood. Neuroinflammation has been identified as key contributor to pathology. In this study, we explored the potential link between core clock molecule Rev-erbα and microglia-mediated NLR family pyrin domain-containing 3 (NLRP3) inflammasome pathogenesis.We first examined diurnal rhythms changes inflammatory cytokines expression SN of MPTP-induced...
Background: Perioperative neurocognitive disorders (PND), including delayed recovery (dNCR) and postoperative cognitive dysfunction (POCD), are common complications in elderly patients adversely affect their prognosis. The study was designed to explore the effects of esketamine on function who underwent gastrointestinal surgery under general anesthesia its potential mechanism. Methods: Eighty-four aged 65 above undergoing were randomly divided into 2 groups: group (group S) control C). Group...
Objective: To investigate the effects of different intensities arm rehabilitation training on functional recovery hemiplegic upper extremity. Design: A randomized controlled trial. Interventions: Thirty-two stroke patients meeting enrolment criteria were randomly divided into three groups: group ( n = 11), B 10) and C 11). Each received for 1 hour, 2 hours 3 a day respectively, 5 days per week, period six weeks. Main measures: Motor function was assessed by Fugl-Meyer Assessment, Action...
The incidence of thyroid cancer has been increased in the past few decades. GPX3 gene is located 5q23, which frequently deleted prostate cancer. Methylation was found prostate, esophagus, gastric and breast cancers. To detect expression analyze mechanism human cancer, 94 cases primary papillary (PTC) coupled with adjacent tissue samples, as well 15 normal epithelial samples were collected. specific PCR (MSP), immunohistochemistry staining, transwell assay siRNA knockdown technique employed....
Neuroinflammation is a hallmark that leads to selective neuronal loss and/or dysfunction in neurodegenerative disorders. Microglia-derived lysosomal cathepsins are increasingly recognized as important inflammatory mediators trigger signaling pathways aggravate neuroinflammation. However, cathepsin H (Cat H), cysteine protease, has been far less studied neuroinflammation, compared B, D, L, and S. The expression patterns functional roles of Cat the brain neuroinflammation remain unknown....
Background Musculoskeletal pain is commonly experienced in patients with Parkinson's disease (PD). Few studies have investigated the clinical characteristics and risk factors associated musculoskeletal pain. Objectives To investigate distribution, characteristics, a large sample of PD. Methods We enrolled 452 from two clinics used standardized questionnaire to collect demographic information. was diagnosed based on Ford Classification System, severity assessed numeric rating scale (NRS)....
Administration of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) is believed to be an effective method for treating neurodevelopmental disorders. In this study, we investigated the possibility hUC-MSCs treatment neonatal hypoxic/ischemic brain injury associated with maternal immune activation and underlying mechanism. We established rat models by exposing pregnant rats lipopolysaccharide on day 16 or 17 pregnancy. Rat offspring were intranasally administered postnatal 14....
Abstract Motivation Use of multi-omics data carrying comprehensive signals about the disease is strongly desirable for understanding and predicting progression, cancer particularly as a serious with high mortality rate. However, recent methods currently fail to effectively utilize survival prediction thus significantly limiting accuracy using omics data. Results In this work, we constructed deep learning model multimodal representation integration predict patients We first developed an...