A5068093752- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- Endoplasmic Reticulum Stress and Disease
- NF-κB Signaling Pathways
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Natural product bioactivities and synthesis
- Protein Tyrosine Phosphatases
- Cell death mechanisms and regulation
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- interferon and immune responses
- Cancer-related gene regulation
- RNA Research and Splicing
- Microbial Natural Products and Biosynthesis
- Phytochemical compounds biological activities
- Curcumin's Biomedical Applications
Nanjing University
2016-2025
Nanjing Drum Tower Hospital
2018-2025
Tianjin Medical University
2024
China-Japan Friendship Hospital
2024
Chongqing Three Gorges University
2024
Shanxi Agricultural University
2024
Second Affiliated Hospital of Zhejiang University
2024
State Key Laboratory of Pharmaceutical Biotechnology
2014-2023
Nanjing Medical University
2011-2023
Hangzhou Medical College
2020-2023
New multiplex PCR sets of commonly used short tandem repeat (STR) markers have been developed to produce products that are reduced in size when compared standard commercial STR kits. The reduction these amplicons can facilitate the examination and analysis degraded DNA evidence by improving amplification efficiency. This "miniSTR" approach will permit current forensic practitioners use instrumentation already present their laboratories generate genotyping data is directly comparable...
Genetic studies of Tibetans, an ethnic group with a long-lasting presence on the Tibetan Plateau which is known as highest plateau in world, may offer unique opportunity to understand biological adaptations human beings high-altitude environments. We conducted genome-wide study 1,000,000 genetic variants 46 Tibetans (TBN) and 92 Han Chinese (HAN) for identifying signals (HAAs) genomes. discovered most differentiated between TBN HAN at chromosome 1q42.2 2p21. EGLN1 (or HIFPH2, MIM 606425)...
Human pluripotent stem cells (hPSCs), including embryonic and induced cells, are potentially useful in regenerative therapies for heart disease. For medical applications, clinical-grade cardiac must be produced from hPSCs a defined, cost-effective manner. Cell-based screening led to the discovery of KY02111, small molecule that promotes differentiation cardiomyocytes. Although direct target KY02111 remains unknown, results present study suggest by inhibiting WNT signaling but manner is...
Nonresolving inflammation in the intestine predisposes individuals to development of colitis-associated cancer (CAC). Inflammasomes are thought mediate intestinal homeostasis, and their dysregulation contributes inflammatory bowel diseases CAC. However, few agents have been reported reduce CAC by targeting inflammasomes. Here we show that small molecule andrographolide (Andro) protects mice against azoxymethane/dextran sulfate sodium-induced colon carcinogenesis through inhibiting NLRP3...
Background & Aims: Overexpression of cyclooxygenase-2 (COX-2) is implicated in many steps cancer development. Single nucleotide polymorphisms (SNPs) the COX-2 promoter might contribute to differential expression and subsequent interindividual variability susceptibility cancer. This study sought identify functional SNPs evaluated their effects on risk developing esophageal squamous cell carcinoma (ESCC). Methods: Thirty individual DNA samples were sequenced search for SNPs, function was...
Aberrant activation of NLRP3 inflammasome has an important function in the pathogenesis various inflammatory diseases. Although many components and mediators have been identified, how is regulated to prevent excessive inflammation unclear. Here we show stimulators trigger Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2) translocation mitochondria, interact with dephosphorylate adenine nucleotide translocase 1 (ANT1), a central molecule controlling mitochondrial...
Adenosine monophosphate-activated protein kinase (AMPK), a crucial molecule in energy metabolism, is reported to play potential role gut epithelial differentiation and barrier function recently; however, its performance mechanisms the pathological process of inflammatory bowel diseases remain unidentified. In this study, we have found that phosphorylation AMPK colonic tissues negatively correlated with severity disease during initiation development experimental colitis induced by dextran...
Platinum-based doublets with a third-generation agent are the recommended option for many patients non-small cell lung cancer (NSCLC) no contraindications to platinum compounds. Unfortunately, clinical effectiveness of such chemotherapy is limited by intrinsic or acquired resistance.Circulating exosomal miRNAs were isolated and used perform HiSeq deep-sequencing analyses on serum pool samples from platinum-resistant platinum-sensitive patients, six further validated their predictive utility...
Exosomes are important mediators of intercellular communication. Previously, we characterized circulating exosomal miR-425-3p as a non-invasive prognostic marker for predicting clinical response to platinum-based chemotherapy in patients with non-small cell lung cancer (NSCLC).Circulating was validated by qRT-PCR paired serum samples from NSCLC during the course chemotherapy. Cell coculture performed examine effects on sensitivity recipient A549 cells cisplatin. Using bioinformatics, ChIP...
We describe an integrated java-based program that provides elaborate graphic and plain-text output of pairwise linkage disequilibrium (LD) analysis single nucleotide polymorphisms genotypic data. It is most suitable for molecular geneticists, who are focusing on LD measures estimation, statistical significance test extent prediction.The software available at: http://www.chgb.org.cn/lda/lda.htm.Detailed tutorials, LDA help system examples distributed within software. For Macintosh OS X user,...
Objective: Diagnosis of schizophrenia is currently dependent on symptom-based criteria and lacks objective indicators. In this study, the authors investigated whether circulating miRNA can serve as a diagnostic biomarker for schizophrenia. Methods: Global plasma miRNAs were profiled in test cohort 164 patients 187 control subjects, using Solexa sequencing, TaqMan Low Density Array, quantitative reverse transcription polymerase chain reaction (qRT-PCR) assays. The captured then validated by...
Iguratimod, a novel disease-modifying antirheumatic drug, which is now used in clinics China and Japan, has been confirmed as highly efficacious safe drug for rheumatoid arthritis therapy. The antiarthritic mechanism of iguratimod, especially compared with that the classical drugs, not elucidated. In this study, we conducted comparative analysis effects iguratimod two reference methotrexate leflunomide. We found dose dependently potently inhibited arthritic inflammation synovium...
An extensive association analysis of PON gene cluster (PONs) with coronary heart disease (CHD) was performed in Chinese Han population.Thirty polymorphisms PON1, PON2, and PON3 were identified by direct sequencing genomic DNA derived from 48 randomly selected patients. Twelve additionally investigated for CHD 474 male patients 475 controls. Univariate analyses showed the cases had significantly higher frequencies PON1 192Q allele, 160R -162A PON2 311C allele than seen Logistic regression...
Phosphatase of regenerating liver-3 (PRL-3) has been suggested as a potential target for anticancer drugs based on its involvement in tumor metastasis. However, little is known about small-molecule inhibitor against PRL-3. In this study, we report that curcumin, the component spice turmeric, shows antitumor effect by selectively down-regulating expression PRL-3 but not family members PRL-1 and -2 p53-independent way. Curcumin inhibited phosphorylation Src stat3 partly through...
Human liposarcoma is the most common soft tissue sarcoma. There no effective therapy so far except for surgery. In this study, we report first time that curcumin induces endoplasmic reticulum (ER) stress in human cells via interacting with sarcoplasmic/endoplasmic Ca(2+)-ATPase 2 (SERCA2). Curcumin dose-dependently inhibited cell survival of line SW872 cells, but did not affect normal adipose-derived cells. Curcumin-mediated ER inhibiting activity SERCA2 caused increasing expressions CHOP...