A5013818650- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Immune cells in cancer
- Pharmacological Effects of Natural Compounds
- Autophagy in Disease and Therapy
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Inflammasome and immune disorders
- HIV-related health complications and treatments
- HIV Research and Treatment
- Quantum Information and Cryptography
- Quantum Computing Algorithms and Architecture
- Natural product bioactivities and synthesis
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and biological activity of medicinal plants
- Soil Carbon and Nitrogen Dynamics
- Berberine and alkaloids research
- Inflammatory Bowel Disease
- Mechanisms of cancer metastasis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ginseng Biological Effects and Applications
- Phytochemical Studies and Bioactivities
- Inflammation biomarkers and pathways
- Quantum Mechanics and Applications
- Gut microbiota and health
Yancheng Third People's Hospital
2025
Nanjing University
2015-2024
Ningxia Academy of Agriculture and Forestry Sciences
2023-2024
Nanjing Drum Tower Hospital
2018-2022
Yancheng First People's Hospital
2022
Nantong University
2022
China Pharmaceutical University
2008-2021
Nanjing University of Posts and Telecommunications
2018-2020
Pharmaceutical Biotechnology (Czechia)
2014-2019
State Key Laboratory of Pharmaceutical Biotechnology
2014-2019
Nonresolving inflammation in the intestine predisposes individuals to development of colitis-associated cancer (CAC). Inflammasomes are thought mediate intestinal homeostasis, and their dysregulation contributes inflammatory bowel diseases CAC. However, few agents have been reported reduce CAC by targeting inflammasomes. Here we show that small molecule andrographolide (Andro) protects mice against azoxymethane/dextran sulfate sodium-induced colon carcinogenesis through inhibiting NLRP3...
Nonalcoholic fatty liver disease (NAFLD) is the most common and affects millions of people worldwide. Despite increasing prevalence NAFLD, exact molecular/cellular mechanisms remain obscure effective therapeutic strategies are still limited. It well-accepted that free acid (FFA)-induced lipotoxicity plays a pivotal role in pathogenesis NAFLD. Inhibition FFA-associated hepatic toxicity represents potential strategy. Glycyrrhizin (GL), major bioactive component licorice root extract, has...
Nonalcoholic steatohepatitis (NASH), the progressive form of nonalcoholic fatty liver disease (NAFLD), is becoming a common chronic with characteristics steatosis, inflammation and fibrosis. Macrophage plays an important role in development NASH. In this study, Annexin A5 (Anx A5) identified special effect on hepatic macrophage phenotype shift from M1 to M2. And it further demonstrated that Anx significantly switches metabolic reprogramming glycolysis oxidative phosphorylation activated...
Adenosine monophosphate-activated protein kinase (AMPK), a crucial molecule in energy metabolism, is reported to play potential role gut epithelial differentiation and barrier function recently; however, its performance mechanisms the pathological process of inflammatory bowel diseases remain unidentified. In this study, we have found that phosphorylation AMPK colonic tissues negatively correlated with severity disease during initiation development experimental colitis induced by dextran...
Abstract Excessive activation of hepatic stellate cells (HSCs) is a key step in liver fibrogenesis. Here we report that CUG-binding protein 1 (CUGBP1) expression elevated HSCs and positively correlates with fibrosis severity human biopsies. Transforming growth factor-beta (TGF-β) selectively increases CUGBP1 cultured p38 mitogen-activated kinase (MAPK)-dependent manner. Knockdown inhibits alpha smooth muscle actin (α-SMA) promotes interferon gamma (IFN-γ) production vitro . We further show...
Radiation therapy (RT) has the capacity to induce immunogenic death in tumor cells, thereby potentially inducing situ vaccination (ISV) prime systemic antitumor immune responses. However, RT alone is often faced with various limitations during ISV induction, such as insufficient X-ray deposition and an immunosuppressive microenvironment. To overcome these limitations, we constructed nanoscale coordination particles AmGd-NPs by self-assembling high-Z metal gadolinium (Gd) small molecular CD73...
Crohn's disease is a common, chronic inflammatory bowel condition characterized by remission and relapse. Accumulating evidence indicates that activated T cells play an important role in this disease. In the present study, we aimed to examine effect of beauvericin, natural cyclic peptide, on 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis mice, which mimics Beauvericin significantly reduced weight loss, diarrhea mortality, accompanied with notable alleviation macroscopic...
Acute liver injury (ALI), often caused by viruses, alcohol, drugs, etc., is one of the most common clinical diseases. Although pyroptosis plays an important role in ALI, there still a lack effective drugs related to this mechanism. Here, we show that phenethyl isothiocyanate (PEITC), natural compound present cruciferous vegetables, can significantly alleviate concanavalin A (ConA)-induced inflammatory damage and carbon tetrachloride (CCl 4 )-induced chemical dose-dependent manner. PEITC...
Abstract Macrophages, with diverse functions and variable phenotypes, are considered as an important executor of inflammatory diseases. And it has been proved that autophagy is deeply connected the development inflammation, while exact regulatory mechanism still remains unclear, application regulators in anti-inflammation needs to be further confirmed. Here, we firstly verified neochromine S5 (hereinafter referred S5) significantly inhibited M1-like macrophage polarization decrease...
Treatment of systemic lupus erythematosus (SLE), a chronic inflammatory disease, involves the long-term use immunosuppressive agents with significant side effects. New therapeutic approaches are being explored to find better treatment possibilities. In this study, age-matched female MRL/lpr mice were treated orally natural flavonoid astilbin. Astilbin administration started either at week 8 or 12 age though 20. early regimen, astilbin reduced splenomegaly / lymphomegaly, autoantibody...
Abstract Periodontal bone regeneration is a major challenge in the treatment of periodontitis. However, regenerative vitality periodontal ligament cells (PDLCs) declines environment periodontitis and accompanying oxidative stress. This study aimed to investigate functional mechanisms Bach1, transcriptional suppressor involved stress response, its regulation PDLC osteogenesis under inflammatory conditions. We observed significant elevation Bach1 expression tissues with PDLCs Knockdown...