A5101947582- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Case Reports on Hematomas
- Renal Diseases and Glomerulopathies
- Neurobiology and Insect Physiology Research
- Osteoarthritis Treatment and Mechanisms
- Gout, Hyperuricemia, Uric Acid
- MicroRNA in disease regulation
- Apelin-related biomedical research
- Hippo pathway signaling and YAP/TAZ
- Sphingolipid Metabolism and Signaling
- Advanced Glycation End Products research
- Melanoma and MAPK Pathways
- Brain Metastases and Treatment
- HVDC Systems and Fault Protection
- Optimism, Hope, and Well-being
- Liver physiology and pathology
- Nephrotoxicity and Medicinal Plants
- Inflammasome and immune disorders
- Peptidase Inhibition and Analysis
- Lower Extremity Biomechanics and Pathologies
- Cellular transport and secretion
- Ureteral procedures and complications
Changzhou No.2 People's Hospital
2019-2025
Nanjing Traditional Chinese Medicine Hospital
2025
Nanjing Medical University
2010-2024
Xuzhou Medical College
2017-2024
Harbin Medical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
Anhui Medical University
2023
Second Hospital of Anhui Medical University
2023
Nanjing University
2016
Second Affiliated Hospital of Nanjing Medical University
2013
Most chronic kidney injuries inevitably progress to irreversible renal fibrosis. Tubular epithelial-to-mesenchymal transition (EMT) is recognized play pivotal roles in the process of However, a comprehensive understanding pathogenesis scar formation and progression remains an urgent task for researchers. The endogenously produced microRNAs (miRNAs), proved important gene regulation, probably regulate most genes involved EMT. In this study, we applied microarray analysis investigate...
Despite the recent attention focused on important role of autophagy in maintaining podocyte homeostasis, little is known about changes and mechanisms dysfunction under diabetic condition. In this study, we investigated biology its involvement pathogenesis nephropathy. Podocytes had a high basal level autophagy. And inhibition either by 3-methyladenenine (3-MA) or Beclin-1 siRNA was detrimental to architectural structure. However, condition vivo glucose conditions vitro, podocytes became...
Accurately predicting pathological complete response (pCR) to neoadjuvant treatment (NAT) in breast cancer remains challenging due tumor heterogeneity. This study enrolled 2279 patients across 12 centers and develops a novel multi-modality model integrating longitudinal magnetic resonance imaging (MRI) spatial habitat radiomics, transcriptomics, single-cell RNA sequencing for pCR. By analyzing subregions on multi-timepoint MRI, the captures dynamic intra-tumoral heterogeneity during NAT. It...
Inflammation is a pathologic feature of hyperuricemia in clinical settings. However, the underlying mechanism remains unknown. Here, infiltration T cells and macrophages were significantly increased mice kidneys. This inflammatory was accompanied by an up-regulation TNF-α, MCP-1 RANTES expression. Further, largely located tubular interstitial spaces, suggesting role for hyperuricemia-induced inflammation. In cultured epithelial (NRK-52E), uric acid, probably transported via urate...
BackgroundOsteosarcoma (OS) is a malignant tumor mainly occurring in young people. Due to the limited effective therapeutic strategies, OS patients cannot achieve further survival improvement. G-protein-coupled receptors (GPCRs) constitute largest family of cell membrane and consequently hold significant promise for imaging targeted therapy. We aimed explore biological functions Sphingosine 1-phosphate receptor 3 (S1PR3), one members GPCRs family, possibility S1PR3 as an target treatment...
Matrix metalloproteinase-9 (MMP-9) is one of the major components matrix proteolytic network, and its role in pathogenesis renal interstitial fibrosis remains largely unknown. Here, we demonstrate that ablation MMP-9 attenuated fibrotic lesions obstructive nephropathy. Mice lacking were less likely to develop morphological injury, which was characterized by a reduced disruption tubular basement membrane (TBM) expression fibronectin as well deposition total tissue collagen kidneys after...
Abstract Excessive activation of hepatic stellate cells (HSCs) is a key step in liver fibrogenesis. Here we report that CUG-binding protein 1 (CUGBP1) expression elevated HSCs and positively correlates with fibrosis severity human biopsies. Transforming growth factor-beta (TGF-β) selectively increases CUGBP1 cultured p38 mitogen-activated kinase (MAPK)-dependent manner. Knockdown inhibits alpha smooth muscle actin (α-SMA) promotes interferon gamma (IFN-γ) production vitro . We further show...
Abstract Podocytes, a type of highly specialized epithelial cells, require substantial levels energy to maintain glomerular integrity and function, but little is known on the regulation podocytes’ energetics. Lack metabolic analysis during podocyte development led us explore distribution mitochondrial oxidative phosphorylation glycolysis, two major pathways cell metabolism, in cultured podocytes vitro differentiation. Unexpectedly, we observed stronger glycolytic profile, accompanied by an...
Objectives The aim of this study was to detect levels common lipid species in serum and synovial fluid (SF) primary knee osteoarthritis (OA) patients investigate their correlations with disease severity. Materials Methods enrolled 184 OA receiving arthroscopic debridement or total arthroplasty 180 healthy controls between April 2012 March 2018. Total triglycerides (TG), cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C), apolipoprotein A1 (ApoA1), B (ApoB) were analyzed...
Urate is produced as the major end product of purine metabolism. In last decade, incidence hyperuricemia increased markedly, and similar trends in epidemiology metabolic syndrome have been observed. Hyperuricemia associated with renal disease, recent studies reported that mild results hypertension, intrarenal vascular injury. This has led to hypothesis uric acid may contribute fibrosis progressive disease. Our purpose was investigate relationship between tubular We applied method...
Abstract Aim Leptin is an important peptide hormone that regulates food intake and plays a crucial role in modulating olfactory function. Although few previous studies have investigated the effect of leptin on odor perception discrimination rodents, research neural basis underlying behavioral changes lacking. Here we study how affects performance during go/no‐go task it modulates activity mitral/tufted cells bulb, which information processing representation. Methods A was used test. For vivo...
Renal fibrosis is a final common pathway of chronic kidney disease. Sustained activation fibroblasts considered to play key role in perpetuating renal but the driving force perpetuation stage only partially understood. To date, some investigations have specifically identified overexpression microRNA 21 (miR-21) progression fibrosis. Nevertheless, precise miR-21 fibroblast remains largely unknown. In this study, we found that was significantly upregulated activated and it maintained itself at...
Aristolochic acid nephropathy, initially found in patients intaking of slimming herbs containing aristolochic (AA), was previously considered as a progressive renal interstitial fibrosis and urothelial malignancy. However, the presence albuminuria some with AAN suggests that AA may also damage glomerular filtration barrier. In this study, mice model generated by daily administration I sodium salt intraperitoneally at dose 6 mg/kg body weight for 3 days. All developed heavy day 7 after...
Insulin is an important peptide hormone that regulates food intake and olfactory function. While a multitude of studies investigated the effect insulin in bulb epithelium, research on how it modulates higher centers lacking. Here we investigate neural activity pyramidal neurons anterior piriform cortex, key signal processing center plays roles odor perception, preference learning, pattern separation. In vitro find from brain slice recordings increases excitation neurons, excitatory synaptic...
Anillin (ANLN) is a highly conserved protein involved in cytokinesis and cytoskeletal remodeling. This study investigates the role of ANLN head neck squamous cell carcinoma (HNSCC) progression its impact on tumor immune microenvironment, with focus combination silencing anti-programmed death 1 (PD-1) therapy. Through vitro vivo experiments, along clinical specimen analysis, we discovered that not only inhibits malignant HNSCC but also reduces activation extracellular signal-regulated...
Background: Osteoarthritis (OA) is one of the leading causes pain and disability. Metabolomics a recent approach to identifying moieties that can be used in diagnosis, prognosis, as biomarkers. The articular fluid OA witnesses its pathophysiology directly. Identifying differential metabolites biological pathways associated with them provide in-depth mechanisms identify Aim: In present study, synovial confirmed patients (n=17) matched healthy controls (n=21) was investigated for using...
The development of the pancreatic head originates from fusion ventral and dorsal primordia during embryonic development. Theoretically, origin cancer also exists pancreas pancreas. Among 49 patients with cancer, was divided into originating (PHCv) or (PHCd) through imaging pathological classification. clinical data collected compared between PHCv group PHCd group. results showed that had worse long-term survival than those (10 months vs 14.5 months). Similarly, progression-free (PFS)...
The objective is to investigate the effects of apelin-13 in models post-traumatic stress disorder (PTSD). Mature male CD1 mice were subjected single prolonged method induce PTSD-related behaviors. These behaviors then evaluated using elevated plus maze test, Morris water and open field test. Hippocampal neural cell death was assessed propidium iodide labeling. expression hippocampal autophagy pathway-associated proteins determined through immunoblotting analysis, LC3 levels also measured via...
Diabetic kidney disease (DKD) is responsible for nearly half of all end stage and failure a major driver mortality among patients with diabetes. To date, few safe effective drugs are available to reverse the decline function. Kidney tubules producing energy by fatty acid metabolism pivotal in development deterioration DKD. Peroxisome proliferator-activated receptors (PPARs), comprising PPARα, PPARδ PPARγ play senior role pathogenesis DKD function glycemic control lipid metabolism; whereas...