A5102025583- Inflammatory Bowel Disease
- Microscopic Colitis
- Autoimmune and Inflammatory Disorders
- SARS-CoV-2 and COVID-19 Research
- Frailty in Older Adults
- Ovarian function and disorders
- Gastrointestinal motility and disorders
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Clinical Research Studies
- Helicobacter pylori-related gastroenterology studies
- Diabetes and associated disorders
- Liver Diseases and Immunity
- Cancer Immunotherapy and Biomarkers
- Immune responses and vaccinations
- Pancreatic function and diabetes
- Ocular Diseases and Behçet’s Syndrome
- Radiomics and Machine Learning in Medical Imaging
- Liver Disease Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Medical Imaging Techniques and Applications
- Immunodeficiency and Autoimmune Disorders
- Lipid metabolism and disorders
- Whipple's Disease and Interleukins
- Vaccine Coverage and Hesitancy
- PARP inhibition in cancer therapy
China Medical University
2002-2025
First Hospital of China Medical University
2002-2025
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
Tianjin University of Traditional Chinese Medicine
2015-2024
Guangdong Pharmaceutical University
2022
Xinjiang Medical University
2017-2021
Sichuan University
2019
West China Hospital of Sichuan University
2019
Accurately predicting pathological complete response (pCR) to neoadjuvant treatment (NAT) in breast cancer remains challenging due tumor heterogeneity. This study enrolled 2279 patients across 12 centers and develops a novel multi-modality model integrating longitudinal magnetic resonance imaging (MRI) spatial habitat radiomics, transcriptomics, single-cell RNA sequencing for pCR. By analyzing subregions on multi-timepoint MRI, the captures dynamic intra-tumoral heterogeneity during NAT. It...
Neoadjuvant chemoimmunotherapy (NACI) has emerged as the standard treatment for early-stage triple-negative breast cancer (TNBC). However, reliable biomarkers identifying patients who are likely to benefit from NACI lacking. This study aims develop an intratumoral microbiota-aided radiomics model predicting pathological complete response (pCR) in with TNBC. Intratumoral microbiota characterized by 16S rDNA sequencing and quantified through experimental assays. Single-cell RNA is performed...
ABSTRACT Aims Inattention in young people is one of the main reasons for their declining learning ability. Frontoparietal networks (FPNs) are associated with attention and executive function. Brain computer interface (BCI) training has been applied neurorehabilitation, but there a lack research on its application to cognition. This study aimed investigate effect BCI network healthy adults. Methods Twenty‐seven performed 5 consecutive days. An test (ANT) was at baseline immediately after...
Background Neoadjuvant immunotherapy combined with chemotherapy (Chemo-IM) is associated significantly improved pathological complete response (pCR) rates and long-term survival outcomes in patient early-stage triple-negative breast cancer (TNBC). However, only a small proportion of patients benefit from the addition immunotherapy. Here, we explored confirmed role intratumoral microbiota screening TNBC who are likely to neoadjuvant Chemo-IM. Methods Patients previously untreated,...
Immune checkpoint inhibition therapy using targeted monoclonal antibodies is a relatively new therapeutic approach for patients with several cancer types including non-small cell lung cancer1. Targeted based drugs can activate anti-tumor immunity by blocking immune receptors (CTLA-4, PD-1 receptor and its ligand PD-L1), in order to restore T-cell effector function2,3. However, the use of inhibitors lead unique side effect profile termed as immune-related adverse events (irAEs). Loss results...
This study is to investigate the relationship of programmed cell death 1 (PD-1; also known as PDCD1) and death-1-ligand (PD-L1; CD274) single nucleotide polymorphisms (SNPs) with polycystic ovary syndrome (PCOS). enrolled 330 PCOS patients 350 matched controls. ELISA was used detect PD-1 PD-L1 levels in serum. SnaPshot genotyping performed analyze genotyping. Linkage disequilibrium haplotype TagSNP loci genes were detected. The genotypes alleles analyzed. serum significantly lower than those...
Monoamine oxidase (MAO) is regarded as a mitochondrial enzyme. This enzyme localizes on the outer membrane of mitochondria. There are two kinds MAO isozymes, type A (MAOA) and B (MAOB). Previous studies have shown that MAOB activity found in pancreatic islets. islets increased by fasting-induced decrease plasma glucose level. Islet cells contain monoamines their secretory granules. These inhibit secretion insulin from cells. active degrading monoamines. Therefore, may influence...
Ulcerative colitis (UC) is a chronic inflammatory disorder of the gastrointestinal tract. Tumor necrosis factor (TNF) inhibitors such as infliximab (IFX) are used to treat UC. But TNF can induce psoriasis, which was characterized by IL-17/IL-22 expressing Th17 cells and IFN-γ Th1 cells, with increased expression correlated more severe skin lesions need for Ustekinumab (UST) therapy1. UST monoclonal antibody that binds p40 subunit interleukin (IL)-12 IL-23. It has shown remarkable efficacy in...
Background: The aim is to study the relationship between single nucleotide polymorphism (SNP) of polycystic ovary syndrome (PCOS) susceptibility locus in THADA gene (rsl3429458) and PCOS Xinjiang Uygur women. Methods: Seventy-seven patients with were enrolled from Reproductive Center First Affiliated Hospital Medical University during May 2013 January 2017; whereas 62 matched Uighur women reproductive age normal menstruation set as control group. Results: (1) levels body mass index,...
It is difficult to manage UC patients with tumor and extraintestinal manifestations (EIMs). We present this case of acute severe patient peripheral arthritis orbital could be successfully managed by the concomitant use two biologics (Dual targeted therapy, DTT) including vedolizumab (VDZ) ustekinumab (UST). VDZ approved for treatment moderate-to-severe UC, but might have limited efficacy in treating EIMs due its gut specific mechanism. UST shows clinical used treatment.