A5014137444- Eicosanoids and Hypertension Pharmacology
- Viral Infections and Immunology Research
- Cardiovascular Function and Risk Factors
- COVID-19 Clinical Research Studies
- Hormonal Regulation and Hypertension
- Cardiac electrophysiology and arrhythmias
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cardiomyopathy and Myosin Studies
- Ion channel regulation and function
- Circular RNAs in diseases
- Peroxisome Proliferator-Activated Receptors
- Long-Term Effects of COVID-19
- Cardiac Fibrosis and Remodeling
- Cancer, Hypoxia, and Metabolism
- Pharmacogenetics and Drug Metabolism
- RNA modifications and cancer
- Cardiac Structural Anomalies and Repair
- Alcohol Consumption and Health Effects
- Genetic Associations and Epidemiology
- RNA Research and Splicing
- Virus-based gene therapy research
- Atrial Fibrillation Management and Outcomes
- Renin-Angiotensin System Studies
- Adipose Tissue and Metabolism
Huazhong University of Science and Technology
2016-2025
Tongji Hospital
2016-2025
Fudan University
2019-2024
First Affiliated Hospital of Zhengzhou University
2019-2024
Jiangxi Pingxiang People's Hospital
2024
Central South University
2024
Second Xiangya Hospital of Central South University
2024
University of Houston
2023-2024
Nanjing Medical University
2011-2023
Jiangsu Province Hospital
2011-2023
Abstract The novel coronavirus disease (COVID-19) outbreak, caused by SARS-CoV-2, represents the greatest medical challenge in decades. We provide a comprehensive review of clinical course COVID-19, its comorbidities, and mechanistic considerations for future therapies. While COVID-19 primarily affects lungs, causing interstitial pneumonitis severe acute respiratory distress syndrome (ARDS), it also multiple organs, particularly cardiovascular system. Risk infection mortality increase with...
Background— The hypothesis that some cases of sudden infant death syndrome (SIDS) could be caused by long-QT (LQTS) has been supported molecular studies. However, there are inadequate data regarding the true prevalence mutations in arrhythmia-susceptibility genes among SIDS cases. Given importance and potential implications these observations, we performed a study to more accurately quantify contribution LQTS gene rare variants. Methods Results— Molecular screening 7 ( KCNQ1 , KCNH2 SCN5A...
Sick sinus syndrome (SSS) describes an arrhythmia phenotype attributed to node dysfunction and diagnosed by electrocardiographic demonstration of bradycardia or arrest. Although frequently associated with underlying heart disease seen most often in the elderly, SSS may occur fetus, infant, child without apparent cause. In this setting, is presumed be congenital. Based on prior associations disorders cardiac rhythm conduction, we screened α subunit sodium channel (SCN5A) as a candidate gene...
Sick sinus syndrome (SSS) describes an arrhythmia phenotype attributed to node dysfunction and diagnosed by electrocardiographic demonstration of bradycardia or arrest. Although frequently associated with underlying heart disease seen most often in the elderly, SSS may occur fetus, infant, child without apparent cause. In this setting, is presumed be congenital. Based on prior associations disorders cardiac rhythm conduction, we screened α subunit sodium channel (SCN5A) as a candidate gene...
Human infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes disease 2019 (COVID-19) and there is no cure currently. The 3CL protease (3CLpro) a highly conserved which indispensable for CoVs replication, promising target development of broad-spectrum antiviral drugs. In this study we investigated the anti-SARS-CoV-2 potential Shuanghuanglian preparation, Chinese traditional patent medicine long history treating tract in China. We showed that either oral liquid...
Objective: To evaluate the cardiovascular damage of patients with COVID-19, and determine correlation serum N-terminal pro B-type natriuretic peptide (NT-proBNP) cardiac troponin-I (cTnI) severity impact concomitant disease on COVID-19 was also evaluated. Methods: A cross-sectional study designed 150 consecutive in fever clinic Tongji Hospital Wuhan from January to February 2020, including 126 mild cases 24 critical care. Both univariate multivariate logistic regression were used analyze...
Rationale: Mitochondrial dysfunction plays an important role in heart failure (HF). However, the molecular mechanisms regulating mitochondrial functions via selective autophagy (mitophagy) are poorly understood. Objective: We sought to determine of AMPK (AMP-activated protein kinase) mitophagy during HF. Methods and Results: An isoform shift from AMPKα2 AMPKα1 was observed failing samples HF patients transverse aortic constriction–induced mice, accompanied by decreased function. The...
COVID-19 is a disease with heterogeneous clinical appearances.Most patients are asymptomatic or exhibit mild to moderate symptoms; approximately 15% progress severe pneumonia and about 5% eventually admitted the intensive care unit (ICU) due acute respiratory distress syndrome (ARDS), septic shock and/ multiple organ failure.2][3] Inadequate identification of determinants fatal outcomes one major obstacles improvement in patients.A previous study reported scoring system (COVID-GRAM) which...
Rationale: Diabetes mellitus is often associated with cardiovascular complications, which the leading cause of morbidity and mortality among patients diabetes mellitus, but little known about mechanism that connects to development dysfunction. Objective: We aim elucidate underlying hyperglycemia-induced cardiac dysfunction on a well-established db/db mouse model for diabetic complications lead heart failure. Methods Results: first profiled expression microRNAs (miRNAs) by microarray...
Aortic aneurysm and dissection (AAD) are high-risk cardiovascular diseases with no effective cure. Macrophages play an important role in the development of AAD. As succinate triggers inflammatory changes macrophages, we investigated significance pathogenesis AAD its clinical relevance.
Abstract Cytochrome P450 (CYP) arachidonic acid epoxygenase 2J2 converts to four regioisomeric epoxyeicosatrienoic acids, which exert diverse biological activities in cardiovascular system and endothelial cells. However, it is unknown whether this enzyme highly expresses plays any role cancer. In study, we found that very strong selective CYP2J2 expression was detected human carcinoma tissues 101 of 130 patients (77%) as well eight cell lines but undetectable adjacent normal nontumoric by...
The congenital long QT syndrome (LQTS) is an inherited disorder characterized by a prolonged cardiac action potential. This delay in cellular repolarization can lead to potentially fatal arrhythmias. One form of LQTS (LQT3) has been linked the human voltage-gated sodium channel gene ( SCN5A ). Three distinct mutations have identified gene. biophysical and functional characteristics each these mutant channels were determined heterologous expression recombinant heart mammalian cell line. Each...