A5003707317- Long-Term Effects of COVID-19
- Functional Brain Connectivity Studies
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Dementia and Cognitive Impairment Research
- EEG and Brain-Computer Interfaces
- Eicosanoids and Hypertension Pharmacology
- Brain Tumor Detection and Classification
- Alzheimer's disease research and treatments
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Acute Myocardial Infarction Research
- Sepsis Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Bioinformatics and Genomic Networks
- Cardiac electrophysiology and arrhythmias
- Gaze Tracking and Assistive Technology
- Peroxisome Proliferator-Activated Receptors
- Neural dynamics and brain function
- Cholesterol and Lipid Metabolism
- Liver Disease Diagnosis and Treatment
- Gene expression and cancer classification
- Cardiomyopathy and Myosin Studies
- Blind Source Separation Techniques
- SARS-CoV-2 and COVID-19 Research
Huazhong University of Science and Technology
2010-2025
Tongji Hospital
2010-2025
Hangzhou Dianzi University
2017-2025
Ministry of Industry and Information Technology
2020-2025
Hangzhou Vocational and Technical College
2021-2025
Zhengzhou University
2024
China-US (Henan) Hormel Cancer Institute
2024
Suzhou Municipal Hospital
2017-2022
Nanjing Medical University
2017-2022
Sun Yat-sen University
2011-2020
Abstract Microalgae are the most abundant microorganisms in aquatic environments, and many possess ability to remove organic contaminants. The presence of endocrine disruption compounds (EDCs) coastal marine systems their associated risks have elicited great concern, especially case nonylphenol (NP), which is classified as a priority contaminate by U.S. EPA. In this context, batch experiments were conducted investigate intracellular absorption, extracellular adsorption biodegradation NP four...
Abstract Importance Coronavirus disease 2019 (COVID-19) is a pandemic with no specific drugs and high mortality. The most urgent thing to find effective treatments. Objective To determine whether hydroxychloroquine application may be associated decreased risk of death in critically ill COVID-19 patients what potential mechanism. Design, Setting Patients This retrospective study included all 568 who were confirmed by pathogen laboratory tests despite antiviral treatment had severe acute...
OBJECTIVE Accumulating evidence suggests that cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into epoxyeicosatrienoic acids (EETs), which play crucial and diverse roles in cardiovascular homeostasis. The anti-inflammatory, antihypertensive, pro-proliferative effects of EETs suggest a possible beneficial role for on insulin resistance diabetes. RESEARCH DESIGN AND METHODS This study investigated the CYP2J3 epoxygenase gene therapy blood pressure diabetic db/db mice model...
For now, Alzheimer's disease (AD) is incurable. But if it can be diagnosed early, the correct treatment used to delay disease. Most of existing research methods use single or multi-modal imaging features for prediction, relatively few studies combine brain with genetic diagnosis. In order accurately identify AD, healthy control (HC) and two stages mild cognitive impairment (MCI: early MCI, late MCI) combined characteristics, we proposed an integrated Fisher score multi-task feature selection...
Alzheimer's disease is an irreversible central neurodegenerative disease, and early diagnosis of beneficial for its prevention intervention treatment. In this study, we propose a novel framework, FusionNet-ISBOA-MK-SVM, which integrates fusion network (FusionNet) improved secretary bird optimization algorithm to optimize multikernel support vector machine diagnosis. The model leverages multimodality data, including functional magnetic resonance imaging genetic information (single-nucleotide...
Transfer RNA-derived small RNAs (tsRNAs) have emerged as potential biomarkers of various human diseases. However, the clinical utility and biological functions tsRNA in acute coronary syndrome (ACS) remain poorly understood. To investigate this, we performed high-throughput RNA sequencing on peripheral blood monocyte cells (PBMCs) from 24 ACS patients 12 healthy controls. Our analysis revealed distinct characteristic expression patterns tsRNAs response to ACS, highlighting their disease...
The generalized nonlinear Schr\"odinger model with distributed dispersion, nonlinearity, and gain or loss is considered the explicit, analytical solutions describing dynamics of bright solitons on a continuous-wave background are obtained in quadratures. Then, generation, compression, propagation pulse trains discussed detail. numerical results show that can be compressed by choosing appropriate control fiber system, generated modulation instability propagate undistorsted along fibers...
The goal of biometrics is to recognize humans based on their physical and behavioral characteristics. Preliminary studies have demonstrated that the electroencephalogram(EEG) potentially more secure private than traditional biometric identifiers. At present, EEG identification method targets specific tasks cannot be generalized. In this study, a novel EEG-based extracts phase synchronization (PS) features for subject proposed under variety tasks. We quantified PS by locking value (PLV) in...
A 360-area surface-based cortical parcellation is extended to study mild cognitive impairment (MCI) and Alzheimer's disease (AD) from healthy control (HC) using the joint human connectome project multi-modal (JHCPMMP) proposed by us. We propose a novel classification method named as JMMP-LRR accurately identify different stages toward AD integrating JHCPMMP with logistic regression-recursive feature elimination (LR-RFE). In three-group classification, average accuracy 89.0% for HC, MCI,...
Novel strategies in intratumoral injection and emerging immunotherapies have heralded a new era of precise cancer treatments. The affinity SARS-CoV-2 to ACE2 receptors, feature which facilitates virulent human infection, is leveraged this research. Colon cells, with their high expression, provide potentially strategic target for using feature. While the highly expression observed several types, idea viral spike protein targeting colon cells offers novel approach treatment. Intratumoral...
We describe a previously uncharacterized ATP-binding cassette A1 super enhancer RNA (ABCA1-seRNA)-mediated cholesterol efflux. In addition, it promoted macrophage inflammatory cytokine release, and was causally correlated with coronary artery disease severity. Mechanistically, ABCA1-seRNA upregulated efflux by interacting mediator complex subunit 23 recruiting retinoid X receptor-alpha liver to promote ABCA1 transcription in cis manner. Meanwhile, induced P65 ubiquitination degradation,...
Introduction: To assess the short-term and long-term outcomes of percutaneous endomyocardial biopsy (EMB) in patients with myocarditis to identify risk factors for EMB-related complications this patient population. Methods: A retrospective analysis was conducted on 294 hospitalized clinically suspected at Tongji Hospital from October 2019 2023, a median follow-up duration 18 months. Patients were divided into an EMB group (n = 151) non-EMB 143) based whether they underwent procedure. The...
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Coronavirus disease 2019 (COVID-19) is a highly contagious and serious threat to human health. COVID-19 can cause multiple organ dysfunction, such as respiratory circulatory failure, liver kidney injury, disseminated intravascular coagulation, thromboembolism, even death. The World Health Organization reports that the mortality rate of severe-type over 50%. Currently, number severe cases worldwide has increased rapidly, but experience in treatment infected patients still limited. Given lack...
In recent years, brain imaging genomics has advanced significantly in revealing underlying pathological mechanisms of Alzheimer's disease (AD) and providing early diagnosis. this paper, we present a framework for diagnosing AD that integrates magnetic resonance (fMRI) genetic preprocessing, feature selection, support vector machine (SVM) model. particular, novel sand cat swarm optimization (SCSO) algorithm, named SS-SCSO, which the spiral search strategy alert mechanism from sparrow is...
Emerging evidence highlights the pivotal roles of long non-coding RNAs (lncRNAs) in lipid metabolism. Apoprotein C3 (ApoC3) is a well-established therapeutic target for hypertriglyceridemia and exhibits strong association with cardiovascular disease. However, exact mechanisms via which lncRNAs control ApoC3 expression remain unclear.