A5101782305- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Lung Cancer Treatments and Mutations
- Renal Diseases and Glomerulopathies
- Pregnancy-related medical research
- Glaucoma and retinal disorders
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Galectins and Cancer Biology
- Atherosclerosis and Cardiovascular Diseases
- Ureteral procedures and complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Chronic Kidney Disease and Diabetes
- Colorectal Cancer Treatments and Studies
- Pelvic and Acetabular Injuries
- Acute Kidney Injury Research
- HER2/EGFR in Cancer Research
- Liver Disease and Transplantation
- interferon and immune responses
- Neurological Disease Mechanisms and Treatments
- Growth Hormone and Insulin-like Growth Factors
- SARS-CoV-2 and COVID-19 Research
- Advanced Breast Cancer Therapies
- Systemic Lupus Erythematosus Research
Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine
2020-2025
Jiangsu Normal University
2025
Central South University
2010-2024
Henan Provincial Chest Hospital
2022-2024
Ningbo University
2024
First Affiliated Hospital of Anhui Medical University
2023-2024
Anhui Medical University
2023-2024
Zhongda Hospital Southeast University
2024
Second Xiangya Hospital of Central South University
2010-2024
Zhengzhou University
2024
Glaucoma is the most prevalent neurodegenerative disease and a leading cause of blindness worldwide. The mechanisms causing glaucomatous neurodegeneration are not fully understood. Here we show, using mice deficient in T and/or B cells adoptive cell transfer, that transient elevation intraocular pressure (IOP) sufficient to induce T-cell infiltration into retina. This leads prolonged phase retinal ganglion degeneration persists after IOP returns normal level. Heat shock proteins (HSP)...
To characterize a glaucoma model of mice, the authors adopted and modified method inducing chronic elevation intraocular pressure (IOP) by anterior chamber injection polystyrene microbeads.Chronic IOP was induced unilaterally in adult C57BL/6J mice injecting microbeads to chamber. Effectiveness different sizes (small, 10 μm; large, 15 μm) on compared, measured every other day using tonometer. After maintaining elevated for 2, 4, or 8 weeks, degree RGC axon degeneration assessed...
Interstitial fibrosis is an inevitable outcome of all kinds progressive chronic kidney disease (CKD). Emerging data indicate that rapamycin can ameliorate by reducing the interstitial infiltrates and accumulation extra cellular matrix (ECM). However, mechanism regulates those changes has not been well understood yet. In this study, we revealed persistent activation mammalian target (mTOR) signaling in macrophages myofibroblasts, but rarely injured proximal epithelial cells, CD4+ T...
Abstract Metabolic regulation has been proven to play a critical role in T cell antitumor immunity. However, cholesterol metabolism as key component of this remains largely unexplored. Herein, we found that the low-density lipoprotein receptor (LDLR), which previously identified transporter for cholesterol, plays pivotal regulating CD8 + activity. Besides involvement uptake is mediated by LDLR priming and clonal expansion, also non-canonical function cells: interacts with T-cell (TCR)...
To evaluate the expression profile of microRNAs (miRNAs) and their roles in human Tenon's fibroblasts (HTFs), to establish an miRNA-based gene-silencing method for antifibrosis vitro.The miRNA was analyzed by microarray using quiescent transforming growth factor beta 1 (TGFβ1)-stimulated primary HTFs, respectively. Candidate miRNAs were identified quantitative RT-PCR. potentially targeting fibrosis-related genes predicted a published algorithm. Predicted regulated candidate confirmed...
Abstract Hepatocellular carcinoma (HCC) stands as the fifth most prevalent malignant tumor on a global scale and presents second leading cause of cancer-related mortality. DNA damage-based radiotherapy (RT) plays pivotal role in treatment HCC. Nevertheless, radioresistance remains primary factor contributing to failure radiation therapy HCC patients. In this study, we investigated functional transketolase (TKT) repair double-strand breaks (DSBs) Our research unveiled that TKT is involved DSB...
To characterize the microbead-induced ocular hypertension (OHT) mouse model and investigate its potential use for preclinical screening evaluation of hypotensive agents, we tested model's responses to major antiglaucoma drugs.Adult C57BL/6J mice were induced develop OHT unilaterally by intracameral injection microbeads. The effects most commonly used drugs, including timolol, brimonidine, brinzolamide, pilocarpine, latanoprost, on IOP glaucomatous neural damage evaluated. Degeneration...
<b><i>Background:</i></b> Septic kidney injury is one of the most common complications in critically ill patients with a high risk developing chronic disease (CKD). Emerging data indicate that mammalian target rapamyci (mTOR) signaling plays major role septic inflammation by regulating immune response macrophage. This study was designed to evaluate mTOR macrophages during endotoxemia-induced and subsequent fibrogenesis. <b><i>Methods:</i></b>...
Type 2 Diabetes Mellitus (T2DM), a prevalent metabolic disorder, often coexists with range of complications, retinopathy being particularly common. Recent studies have shed light on potential connection between diabetic (DR) and hepatic fibrosis, indicating possible shared pathophysiological foundation in T2DM. This study investigates the correlation fibrosis among individuals T2DM, as well evaluates diagnostic value DR for significant fibrosis. Our cross-sectional analysis incorporated 5413...
Disulfidptosis is a new type of regulatory cell death (RCD), but the pathophysiological functions and mechanisms DRGs in CESC remain to be examined. This study explored mutation status disulfidptosis-related genes (DRGs) cervical squamous carcinoma endocervical adenocarcinoma (CESC). After analyzing profiles CESC, this established prognostic model for also differences immune infiltration (accumulation system cells tissues or organs), related enriched pathways, drug sensitivity between...
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. UM develops and sustained by inflammation immunosuppression from tumor microenvironment (TME). This study sought to identify a reliable TME-related biomarker that could provide survival prediction new insight into therapy for patients. Based on clinical characteristics RNA-seq transcriptome data of 80 samples The Cancer Genome Atlas (TCGA) database, PRRX1 as TME- prognosis-related gene was identified using...
CD4+Foxp3+ regulatory T cells (Tregs) are required for normal immune homeostasis. Recent studies suggested that Treg transfer facilitates recovery from acute kidney injury (AKI), but the molecular events maintain function after adoptive remain unclear. This study aimed to investigate regulation of mammalian target rapamycin (mTOR) signaling in Treg-mediated therapeutic effect on ischemic AKI. We noted significant expansion C57BL/6 mouse kidney, with enhanced immunosuppressive capacity renal...
Peripheral blood inflammation indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), and systemic immune-inflammation index (SII), have become research hotspots in diagnosis, treatment, prognosis prediction of breast cancer, whereas existing findings remain controversial.Data pertaining to 1808 cancer patients were collected retrospectively analyze predictive value NLR/PLR/SII for clinicopathological characteristics, chemotherapy response, relapse. 1489,...
Aims . This study is aimed at investigating the pathogenesis of rheumatoid arthritis (RA) by identifying key biomarkers, associated immune infiltration, and small‐molecule compounds using bioinformatic analysis. Methods Six datasets were obtained from Gene Expression Omnibus database, batch effect was adjusted. Functional enrichment analysis Kyoto Encyclopedia Genes Genomes (KEGG) used to analyse differentially expressed genes (DEGs). Furthermore, candidate drugs with RA selected...
Purpose: Acute liver failure (ALF) is a clinically fatal disease that leads to the rapid loss of normal function.Acetaminophen (APAP) leading cause drug-induced ALF.Ferroptosis, defined as iron-dependent cell death associated with lipid peroxide accumulation, has been shown be strongly APAP-induced injury.Growth arrest-specific 1 (GAS1) growth gene, which closely related inhibition and promotion apoptosis.However, functional role underlying mechanism GAS1 in ferroptosis remain...