Pengyu Zhang

ORCID: 0000-0002-1603-637X
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About
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Research Areas
  • Asthma and respiratory diseases
  • Blood Pressure and Hypertension Studies
  • Platelet Disorders and Treatments
  • Cardiac Health and Mental Health
  • Functional Brain Connectivity Studies
  • Chronic Lymphocytic Leukemia Research
  • Psoriasis: Treatment and Pathogenesis
  • Cancer-related Molecular Pathways
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Sirtuins and Resveratrol in Medicine
  • Acute Myeloid Leukemia Research
  • Neuroendocrine regulation and behavior
  • Respiratory and Cough-Related Research
  • Cancer-related molecular mechanisms research
  • Plant Molecular Biology Research
  • Cardiovascular Health and Risk Factors
  • Medical and Biological Ozone Research
  • Breast Lesions and Carcinomas
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Adipose Tissue and Metabolism
  • COVID-19 Clinical Research Studies
  • Nicotinic Acetylcholine Receptors Study
  • Gut microbiota and health
  • Breast Cancer Treatment Studies
  • Neuroscience of respiration and sleep

First Hospital of China Medical University
2023-2025

Hubei University of Medicine
2025

Dongfeng General Hospital
2025

China National Pharmaceutical Group Corporation (China)
2025

Tianjin Medical University Cancer Institute and Hospital
2007-2024

University of Science and Technology of China
2017-2024

China Medical University
2023-2024

University Medical Center of the Johannes Gutenberg University Mainz
2020-2024

Johannes Gutenberg University Mainz
2020-2024

Second Affiliated Hospital of Xi'an Jiaotong University
2012-2024

The devastating Hunga Tonga-Hunga Ha’apai underwater volcano erupted at ~04:15 UT on 15 January 2022. We captured the waves that from propagating in ionosphere by monitoring total electron content (TEC) perturbations utilizing ground-based global navigation satellite system (GNSS) receivers receive electromagnetic signals transmitted geostationary satellites operated BeiDou Navigation Satellite System (BDS). Meanwhile, ground barometers detected unusual enhancements of air pressure traveling...

10.3390/rs14092179 article EN cc-by Remote Sensing 2022-05-02

Hypertension can lead to podocyte damage and subsequent apoptosis, eventually resulting in glomerulosclerosis. Although alleviating apoptosis has clinical significance for the treatment of hypertensive nephropathy, an effective therapeutic target not yet been identified. The function septin4, a proapoptotic protein important marker organ damage, is regulated by post-translational modification. However, exact role septin4 regulating its connection renal remains unclear. We investigated...

10.1161/circresaha.122.321591 article EN cc-by-nc-nd Circulation Research 2023-02-14

Hyperbolic spaces allow for more efficient modeling of complex, hierarchical structures, which is particularly beneficial in tasks involving multi-modal data. Although hyperbolic geometries have been proven effective language-image pre-training, their capabilities to unify language, image, and 3D Point Cloud modalities are under-explored. We extend the modality contrastive pre-training. Additionally, we explore entailment, gap, alignment regularizers learning embeddings facilitating transfer...

10.48550/arxiv.2501.02285 preprint EN arXiv (Cornell University) 2025-01-04

OSCAs are hyperosmolality-gated calcium-permeable channel proteins. In this study, two co-expression modules, which strongly associated with maize proline content, were screened by weighted correlation network analysis, including three ZmOSCA family members. Phylogenetic and protein domain analyses revealed that 12 members classified into four classes, all contained DUF221 domain. The promoter region multiple core elements responsive to abiotic stresses hormones. Colinear analysis ZmOSCAs...

10.3390/ijms21010351 article EN International Journal of Molecular Sciences 2020-01-05

Insulin resistance is often characterized as the most critical factor contributing to development of type 2 diabetes mellitus (T2DM). Sustained high glucose an important extracellular environment that induces insulin resistance. Acquired associated with reduced insulin-stimulated mitochondrial activity a result increased dysfunction. Silent information regulator 1 (SIRT1) one member SIRT2 (Sir2)-like family proteins involved in homeostasis and secretion mammals. Although SIRT1 has...

10.1177/1535370214557218 article EN Experimental Biology and Medicine 2015-02-20

Hydrogen sulfide (H2S), a novel signaling gasotransmitter in the respiratory system, may have antiinflammatory properties lung. We examined preventive and therapeutic effects of H2S on ozone-induced features lung inflammation emphysema. C57/BL6 mice were exposed to ozone or filtered air over 6 weeks. Sodium hydrogen (NaHS), an donor, was administered either before exposure (preventive effect) after completion weeks (therapeutic effect). The ozone-exposed developed emphysema, measured by...

10.1165/rcmb.2015-0014oc article EN American Journal of Respiratory Cell and Molecular Biology 2016-01-05

Parkinson's disease (PD) is characterized by the loss of dopaminergic (DA) neurons in substantia nigra (SN) and aggregation α-synuclein (α-syn). Current PD therapies merely provide symptomatic relief, lacking disease-modifying therapeutic strategies against that could reverse ongoing neurodegeneration. In quest exploring novel modifying strategies, compounds from natural sources have gained much attention recent days. YIAEDAER (Tyr-Ile-Ala-Glu-Asp-Ala-Glu-Arg) peptide a multi-functional...

10.1016/j.biopha.2022.112629 article EN Biomedicine & Pharmacotherapy 2022-01-11

Abstract Background Adipose tissue-derived stem cell (ADSC) transplantation has been shown to be effective for the management of severe liver disorders. Preactivation ADSCs enhanced their therapeutic efficacy. However, these effects have not yet examined in relation cholestatic injury. Methods In present study, a injury model was established by bile duct ligation (BDL) male C57BL/6 mice. Human (hADSCs) with or without tumor necrosis factor-alpha (TNF-α) and interleukin-1beta (IL-1β)...

10.1186/s13287-023-03342-3 article EN cc-by Stem Cell Research & Therapy 2023-04-24
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