To delineate the distribution of perineural invasion (PNI), evaluate its impact on patient survival, and identify optimal criteria for initiating adjuvant radiation therapy (RT) in cases PNI associated with salivary gland cancer (SGC). This retrospective study categorized enrolled patients into three groups based status (none, minor, or major), defined by extent nerve involvement. The influence overall survival locoregional control was assessed using a Cox proportional hazards model. A total...

Objective To elucidate the association between allergy history and response to immune checkpoint inhibition (ICI) in recurrent or metastatic head neck squamous cell carcinoma (RM/HNSCC). Methods Patients receiving ICI treatment for RM/HNSCC were retrospectively enrolled classified into two groups based on their previous history. The primary outcome variable assessed was ICI. Results A total of 157 patients included, whom 27 reported a allergies. In multivariate analysis, with allergies...

Insulin resistance is often characterized as the most critical factor contributing to development of type 2 diabetes mellitus (T2DM). Sustained high glucose an important extracellular environment that induces insulin resistance. Acquired associated with reduced insulin-stimulated mitochondrial activity a result increased dysfunction. Silent information regulator 1 (SIRT1) one member SIRT2 (Sir2)-like family proteins involved in homeostasis and secretion mammals. Although SIRT1 has...

Dental caries is caused by acids from biofilms. pH-sensitive nanoparticle carriers could achieve improved targeted effectiveness. The objectives of this study were to develop novel mesoporous silica nanoparticles carrying nanosilver and chlorhexidine (nMS-nAg-Chx), investigate the inhibition biofilms as well modulation biofilm suppress acidogenic promote benign species for first time.

The reconstruction of mandibular defects after giant ameloblastoma resection is one the most challenging problems facing reconstructive surgeons. Mandibular has been associated with a poor quality life (QOL), particularly in adolescent patients reconstructed free fibula flap. This study aims to evaluate QOL outcomes who have had resections and flap collect information about their socio-cultural situation.The present assessed 45 undergone immediate mandible for faint using University...

Prognostic factors for parotid mucoepidermoid carcinoma (MEC) usually include disease grade, tumor stage, node perineural invasion, and lymphovascular invasion. But the role of intraparotid nodes (IPNs) remains unclear, therefore, study aimed to analyze significance IPNs in predicting recurrence MEC. One hundred ninety patients were included analysis finally. Data regarding demography, pathological characteristics, IPN metastasis, TNM follow up was collected evaluated. The recurrence-free...

Primary parotid squamous cell carcinoma (SCC) is an uncommon tumour, and there limited data on its prognosis treatment. The goal of the current study was to analyse potential prognostic factors clinical outcomes for this tumour type. Consecutive patients with surgically treated primary SCC were retrospectively enrolled in study. end point locoregional control (LRC) disease-specific survival (DSS), which calculated by Kaplan-Meier method. Independent evaluated Cox proportional hazards In...

Objective To analyze the metastasis rate in intraglandular lymph nodes (IGLNs) with a focus on discussing significance of IGLN local control (LC) parotid gland cancer (PGC). Methods A total 337 patients were enrolled. Information including age; sex; and pathologic variables such as tumor (T) stage, metastasis, follow‐up findings was extracted analyzed. Results noted 111 (32.9%) patients. Tumor nodal perineural invasion, resection status, lymphovascular invasion significantly related to...

Objectives This research first investigated the effect of mesoporous silica nanoparticles (nMS) carrying chlorhexidine and silver (nMS-nAg-Chx) on periodontitis-related biofilms. study aimed to investigate (1) antibacterial activity Porphyromonas gingivalis (P. gingivalis) biofilm; (2) suppressing virulence P. (3) regulating multispecies biofilm.

The purpose of the present study was to identify potential function Kruppel-like factor 5 (KLF5) in thyroid cancer and investigate underlying mechanisms. protein levels KLF5 98 tissues were analyzed using an immunohistochemistry assay. SW579 cells transfected with small interfering RNA against B-CPAP expressing vectors used for functional studies. Western blot analysis, immunofluorescence co-immunoprecipitation assays mechanisms KLF5. In vivo tumorigenicity assessed a subcutaneous xenograft...

Objectives: Sarcomatoid carcinoma (SaCa) of the hypopharynx is rare, and its clinical pathologic characteristics prognosis remain unknown. Therefore, study aimed to analyze oncologic outcomes patients with SaCa hypopharynx. Methods: Patients who were surgically treated in period from January 1985 December 2018 enrolled two centers. A matched pair was also performed, each patient one squamous cell (SCC) The main endpoint disease-specific survival (DSS). Results: total 62 (all male) enrolled....

Abstract Background The reconstruction of mandibular defects after trauma or tumor resection is one the most challenging problems facing reconstructive surgeons. Although primary intended outcome surgery to treat head-and-neck malignancies still disease-free survival patient, health-related quality life (HRQOL) now seen as an essential secondary outcome. This study aims evaluate HRQOL outcomes in young patients undergoing mandible with free fibula flap and collect information about their...

Objectives: To analyze the significance of number positive lymph nodes in oral squamous cell carcinoma (SCC) stratified by p16. Methods: A total 674 patients were retrospectively enrolled and divided into 4 groups based on their (0 vs. 1–2 3–4 ≥5). The Kaplan-Meier method was used to calculate disease-free survival (DFS) disease-specific (DSS) rates. Cox model evaluate independent risk factor. Results: p16 showed positivity 85 with a rate 12.6%. In negativity, 5-year DFS rates 52%, 39%, 21%...

Forkhead box P3 (FoxP3) expression in papillary thyroid carcinoma (PTC) is associated with resistance to radioiodine treatment. The sodium iodine symporter (NIS) a plasma membrane glycoprotein, the repression of which may render tumor refractive therapy. In this study, samples from 90 PTCs as well 40 normal tissues were examined for FoxP3 and NIS by immunohistochemistry real-time PCR. We found that was decreased expression. Lentiviral-mediated FoxP3-overexpressing cells constructed PCR...

To investigate the correlations between SIRT1 gene polymorphisms and diabetic kidney disease (DKD). There were 150 patients with DKD in observation group (urinary albumin excretion rate (UAER) ≥ 300 mg 24 h-1), 160 a more than 10 year history of type 2 diabetes but without retinopathy (UAER < 30 h-1) control group. Genotypes three tagged single-nucleotide polymorphism loci (rs3818292, rs4746720 rs10823108) two groups detected. Risks for GG + AG genotype rs10823108 locus 2.96 2.92 times...

To analyze the value of pretreatment neutrophil-to-lymphocyte ratio (NLR) in survival patients with parotid cancer.In total, 249 were enrolled. Information including age, sex, NLR, and pathologic variables such as, tumor stage, intraparotid node (IPN) metastasis, follow-up findings was extracted analyzed.IPN metastasis noted 45 (18.1%) patients, mean NLR 2.48, a range from 1.5 to 6.1. The significantly associated disease grade. A total 73 died disease, 10 -year disease-specific (DSS) rate...

Abstract Our goals was to evaluate how sentinel lymph node biopsy (SLNB) benefit neck management in patients with parotid cancer. Patients diagnosed cN0 cancer by preoperative fine needle puncture were prospectively enrolled. The status evaluated SLNB. If metastasis proved SLNB, a dissection of level I–V performed, or wait-and-see policy conducted for the patient. All related information extracted and analyzed. Positive SLNB result occurred 33 (16.7%) patients, II noted 100% patients....

Objective: Our goal was to evaluate the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) in pediatric patients with parotid cancer. Materials and Methods: Pediatric primary cancer were retrospectively enrolled from several clinical centers. The associations between clinical-pathologic variables NLR for recurrence-free survival (RFS) disease-specific (DSS) analyzed. Results: A total 123 included. mean 2.51 ranged 1.7 6.1. tumor stage disease grade significantly related NLR. In...

Diabetic nephropathy is characterized by inordinate secretion of extracellular matrix (ECM) proteins from mesangial cells (MCs), which tightly associated with excessive activation TGF-β signaling. The forkhead transcription factor O1 (FoxO1) protects hyperglycemia-induced oxidative stress, may be involved in ameliorating the redundant ECM under high glucose conditions. Here, we reported that elevated level p-Akt to attenuate endogenous FoxO1 bioactivities MCs, accompanied decreases mRNA...

Abstract Our goal was to evaluate the prognosis of osteosarcomas (OS) in mandible for finding out best treatment. Patients diagnosed with OS from January 2000 December 2015 were retrospectively enrolled. Demographic, tumor-specific, treatment, and survival data collected analyzed. A total 55 patients (35 male 20 female) included, all had first manifestation swelling. Cachexia occurred 15 (27.3%) patients. Chondroblastic type most common histology subtype followed by osteoblastic type. High...

To assess long-term donor site morbidity after radial forearm free (RFF) flap harvesting.Enrolled patients were asked to complete the Disability of Arm, Shoulder, and Hand (DASH) questionnaire undergo wrist motion hand strength examinations at different time points. The data prospectively collected retrospectively analyzed.The postoperative DASH score did not return normal until 24 months operation. mean degree flexion was significantly decreased compared preoperative level returned 12...