Objectives To investigate the role of lingual lymph node (LLN) metastasis on locoregional control (LRC) in patients with locally advanced tongue squamous cell carcinoma (SCC). Methods A total 231 were prospectively enrolled. Analyses focused association between LLN and clinical pathologic variables as well significance predicting prognosis. Results LLNs noted 58 patients, 33 whom positive for metastasis. was significantly related to adverse characteristics. In metastasis, 5‐year LRC rate...

Sleep disturbances are widespread but usually overlooked health risk factors for coronavirus disease 2019 (COVID-19). We aimed to investigate the influence of pre-existing sleep on susceptibility, severity, and long-term effects COVID-19.

Background: Increasing evidences reveal that inflammation plays a critical role in tumorigenesis and progression. We aimed to develop the nomograms based on inflammatory biomarkers predict micro-vascular invasion (MVI) tumor grade stage I/II hepatocellular carcinoma (HCC).Methods: A retrospective cohort of 627 patients with HCC between January 2007 December 2014 was included study. Logistic regression performed identify independent risk factors MVI. The significant predictors including...

Abstract Background Conditional expression vectors have become a valuable research tool to avoid artefacts that may result from traditional gene studies. However, most systems require multiple plasmids must be independently engineered into the target system, resulting in experimental delay and an increased potential for selection of cell subpopulation differs significantly parental line. We therefore developed pHUSH, inducible system allows regulated shRNA, miRNA or cDNA cassettes on single...

Nod-like receptor C4 (NLRC4) is a member of the (NLR) family, and its expression mediates activation caspase-1 (CASP1). Abnormal NLRC4 CASP1 associated with multiple tumors. However, differences, prognostic value immune correlation in colorectal cancer (CRC) remain to be determined.In this study, TCGA, CCLE, HPA, PrognoScan, STRING GeneMANIA databases were used analyze differences expression, value, genetic alterations cell infiltration CRC patients. Then, we further validated using...

Coastal aquaculture plays a crucial role in global food security and the economic development of coastal regions, but it also causes environmental degradation ecosystems. Therefore, automation, accurate extraction, monitoring areas are for scientific management ecological zones. This study proposes novel deep learning- attention-based median adaptive fusion U-Net (MAFU-Net) procedure aimed at precisely extracting individually separable ponds (ISAPs) from medium-resolution remote sensing...

Objectives: Sarcomatoid carcinoma (SaCa) of the hypopharynx is rare, and its clinical pathologic characteristics prognosis remain unknown. Therefore, study aimed to analyze oncologic outcomes patients with SaCa hypopharynx. Methods: Patients who were surgically treated in period from January 1985 December 2018 enrolled two centers. A matched pair was also performed, each patient one squamous cell (SCC) The main endpoint disease-specific survival (DSS). Results: total 62 (all male) enrolled....

Abstract Blade and balloon atrial septostomy has been used to reduce cardiopulmonary symptoms as a bridge lung or heart transplant in primary pulmonary hypertension. Due severe right dilatation resultant loss of anatomical landmarks, the procedure is technically difficult, reported postprocedure mortality rate varies between 5% 50%. Among others, marked systemic desaturation hypotension presumably secondary an excessively large septal defect have causes death. We report case where novel...

No predictive model for lymph node metastasis (LNM) of superficial esophagogastric junction (EGJ) cancer exists. This study aimed to evaluate incidence, identify risk factors, and develop a nomogram LNM in patients with EGJ cancers.Data were extracted from the Surveillance, Epidemiology, End Results database development internal validation. Another data set was obtained two hospitals external A developed based on independent factors that resulted multivariate logistic regression analysis....

<title>Abstract</title> Wilms tumor is a rare kidney malignancy primarily developed in children. Treatment for includes surgery, radiotherapy, and chemotherapy. Recent studies have demonstrated that microRNAs (miRNAs) play important roles regulating development. In this study, we aimed to elucidate the expression function of miR-378c tumor. Quantitative real-time PCR (qRT-PCR) results showed was downregulated tissues cell lines. Functionally, further CCK-8, would healing, transwell assays...

Objective: To investigate the efficacy and safety of intraperitoneal administration recombinant human endostatin in gastric cancer with malignant ascites. Methods: Clinical data 90 patients (37 an Endostar® combined cisplatin group 53 a group) were retrospectively analyzed. The primary end point was overall survival, secondary points objective response rate (ORR), disease control (DCR) so on. Results: Median survival longer combination (9.7 vs 8.1 months; p = 0.01). ORR DCR higher (ORR:...

Abstract Background The significance of endoscopic evaluation in the diagnosis and management ulcerative colitis (UC) has been widely recognized. Over years, scholars have established several scores. Herein, we assessed clinical application value Mayo Endoscopic Subscore (Mayo ES), Degree Ulcerative Colitis Burden Luminal Inflammation (DUBLIN) score, Index Severity (UCEIS) score UC patients, by comparing their correlation with disease activity predictive potential for treatment response...

Background This study aimed to investigate whether the detection of methylation in promoter Ras association domain family 10 gene ( RASSF10) serum patients with gastric cancer (GC) by methylation-specific PCR (MSP) can be used as a diagnostic and prognostic indicator GC. Methods We MSP examine RASSF10 levels and/or tumor samples from 100 GC patients, 50 chronic atrophic gastritis (CAG), 45 healthy controls (HC). also analyzed clinicopathological follow-up data. Results Our results showed...

Choriocarcinoma accompanied with pulmonary embolism (PE) is rare and difficult to diagnose treat. There are about 25 cases reported in literature, which presented variable clinical characteristics prognosis.We a case of choriocarcinoma presenting PE as the first manifestation 26-year-old Chinese female.Four months before her admission our hospital, she local hospital respiratory manifestations, was diagnosed bronchitis treated antibiotics without improvement, subsequently suspected having...

To construct and verify a diagnostic model using proteomic analysis of serum samples for identifying gastric precancerous lesions cancer (GC).The from 25 patients with (chronic atrophic gastritis mild to moderate dysplasia), GC healthy controls were analyzed matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). Spectral peaks significant difference among the groups identified used as detecting GC. The peptide map was validated an independent sample set...

The validation of the anthocyanin synthase (ANS) gene as a carnation endogenous reference applicable both in classical and real-time PCR methods is prerequisite for development assays genetically modified (GM) detection. This important due to fact that GM lines, developed by Florigene Pty Ltd, have been approved commercialization. In this study, were tested on 14 different cultivars, identical amplification products obtained with all them. No observed samples from other plant species, which...

Objective: To investigate the role of Biyan Qingdu Granule combined with micro-radiation in suppressing nasopharyngeal carcinoma and to explore its mechanism action. Methods: FAT cells were injected into hind limb axilla F344 rats establish a rat tumor model. X-ray radiation was applied oral cavity rats, delivering micro-dose distant tumor. The general condition including mucosal inflammation, size mass, pathological changes tissue, levels TNF-α, IL-1β, IL-6, IL-18, IL-12, ICAM-1, VCAM-1...

ABSTRACT Background and Objectives Distal biliary strictures (DBSs) can be caused by various malignancies, making accurate early diagnosis crucial. Histopathology is the gold standard for diagnosis, with several methods available tissue sampling. This study evaluates performance of EUS-guided fine-needle aspiration (EUS-FNA) cytologic smears histopathology in diagnosing suspected malignant DBSs. Methods A retrospective cohort was conducted on patients who underwent EUS-FNA between January...

microRNA (miRNA) target genes are commonly computationally predicted, yet how dependable predictions remains unclear, as most predicted have not been rigorously tested experimentally. In addition, the degree to which a miRNA differentially inhibits expression of its targets is underappreciated. We selected human miR‐1, miR‐122, and miR‐124 representatives investigate reliability examine miRNAs suppress their genes. first constructed gene reporter libraries for based on three prediction...