A5100423712- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Multiple Sclerosis Research Studies
- Cardiac electrophysiology and arrhythmias
- Sodium Intake and Health
- Cardiovascular Function and Risk Factors
- Ultrasound Imaging and Elastography
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Autoimmune Neurological Disorders and Treatments
- Hormonal Regulation and Hypertension
- Advanced MRI Techniques and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Fatigue and fracture mechanics
- Systemic Lupus Erythematosus Research
- TGF-β signaling in diseases
- Peripheral Neuropathies and Disorders
- Colorectal Cancer Treatments and Studies
- Cardiac Valve Diseases and Treatments
- Renal function and acid-base balance
- Venous Thromboembolism Diagnosis and Management
- Obstructive Sleep Apnea Research
- Cardiac tumors and thrombi
- Blood Pressure and Hypertension Studies
Capital Medical University
2016-2025
China Medical University
2025
First Hospital of China Medical University
2024-2025
Chongqing Three Gorges University
2024
First Affiliated Hospital of Zhengzhou University
2024
Guangxi Medical University
2024
Guilin Medical University
2024
Beijing Chaoyang Emergency Medical Center
2021-2024
Dalian University of Technology
2024
Peking Union Medical College Hospital
2016-2023
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, serves as a conduit for migration. Targeting oncogenes involved in angiogenesis needed treat organ-confined locally advanced ESCC. Although phospholipase C epsilon-1 (PLCE1) gene was originally identified susceptibility ESCC, how PLCE1 ESCC unclear. Matrix-assisted laser desorption ionization time-of-flight mass...
In multiple sclerosis, there is increasing evidence that demyelination, and neuronal damage occurs preferentially in cortical grey matter next to the outer surface of brain. It has been suggested this may be due effects pathology outside brain parenchyma, particular meningeal inflammation or through cerebrospinal fluid mediated factors. White lesions are often located adjacent ventricles brain, suggesting possibility a similar outside-in pathogenesis, but an investigation relationship...
Rationale: Dysbiotic gut microbiota (GM) and NLRP3 inflammasome are proarrhythmic factors in atrial fibrillation (AF).Herein, whether short-chain fatty acid (SCFA) produced from GM fermentation of dietary fiber serving as invisible mediators is yet unclear.Thus, the current study aimed to determine SCFA alleviated signaling-mediated remodeling protects AF development.Methods: First, a cross-sectional based on GC-MS metabolomics was performed explore association between fecal levels traits...
The study aimed to develop and validate a sepsis prediction model using structured electronic medical records (sEMR) machine learning (ML) methods in emergency triage. goal was enhance early screening by integrating comprehensive triage information beyond vital signs. This retrospective cohort utilized data from the MIMIC-IV database. Two models were developed: Model 1 based on signs alone, 2 incorporating signs, demographic characteristics, history, chief complaints. Eight ML algorithms...
Substantial studies have reported the prevalence and affecting factors of subjective cognitive decline (SCD). The complaints screening scale has also been used for probing. However, little is known in China.To investigate risk SCD, explore an SCD China.Stratified cluster random sampling was conducted. 2,689 residents aged 60-80 years completed questionnaire 1. 814 were included clinical neuropsychological evaluations. Two standards to make diagnosis mild impairment (MCI) a preliminary rate...
ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTThe First Zeolite with Three-Dimensional Intersecting Straight-Channel System of 12-Membered RingsZheng Liu, Tetsu Ohsuna, Osamu Terasaki, Miguel A. Camblor, Maria-Jose Diaz-Cabañas, and Kenji HiragaView Author Information CREST, Japan Science Technology Corporation Tohoku University, Sendai 980-8578, Institute for Materials Research, University 980-8577, Department Physics CIR, Industrias Quimicas del Ebro, Poligono de Malpica calle D, no...
<h3>Objective:</h3> To develop a composite MRI-based measure of motor network integrity, and determine if it explains disability better than conventional MRI measures in patients with multiple sclerosis (MS). <h3>Methods:</h3> Tract density imaging constrained spherical deconvolution tractography were used to identify connections 22 controls. Fractional anisotropy (FA), magnetization transfer ratio (MTR), normalized volume computed each tract 71 people relapse onset MS. Principal component...
Objectives To analyse trends in mortality and causes of death among children aged under 5 years Beijing, China between 1992 2015 to forecast under-5 rates (U5MRs) for the period 2016–2020. Methods An entire population-based epidemiological study was conducted. Data collection based on Child Death Reporting Card Beijing Under-5 Mortality Rate Surveillance Network. Trends leading were analysed using χ 2 test SPSS 19.0 software. autoregressive integrated moving average (ARIMA) model fitted...
To investigate the rich-club organization in clinically isolated syndrome (CIS) and multiple sclerosis (MS), to characterize its relationships with physical disabilities cognitive impairments. We constructed high-resolution white matter (WM) structural networks 41 CIS, 32 MS 35 healthy controls (HCs) using diffusion MRI deterministic tractography. Group differences organization, global local network metrics were investigated. The relationship between altered metrics, brain lesions clinical...
Alternations of gut microbiota (GM) in atrial fibrillation (AF) with elevated diversity, perturbed composition and function have been described previously. The current work aimed to assess the association GM AF recurrence (RAF) after ablation based on metagenomic sequencing metabolomic analyses construct a GM-based predictive model for RAF. Compared non-AF controls (50 individuals), profile were significantly altered between patients recurrent (17 individuals) non-RAF group (23 individuals)....
Commonly used tests for diagnosis of salt-sensitive hypertension (SSH) are complex and time-consuming, so new methods required. Many studies have demonstrated roles miRNAs in hypertension; however, the diagnostic value has yet to be determined human SSH. In this study, we examined miRNA expression profiles by initial high-throughput sequencing samples from patients with salt-resistant (SSH SRH, respectively; n = 6, both groups), followed validation quantitative real-time polymerase chain...
Advances in multiplex immunohistochemistry (IHC) techniques and digital pathology platforms allow quantification of multiple proteins at same tissue section produce continuous data. TGF-β signaling plays crucial complex roles colorectal cancer (CRC). We here aimed to investigate clinical pathological relevant involved CRC tissues. Multiplex fluorescent IHC was used quantitative analysis. The levels eight (TGF-β1, TGFBRI, TGFBRII, SMAD4, SMAD2/3, p-SMAD2/3, SMAD1/5/9, p-SMAD1/5/9) were...
Efficacy of immunotherapy is limited in patients with colorectal cancer (CRC) because high expression tumor-derived transforming growth factor (TGF)-β pathway molecules and interferon (IFN)-stimulated genes (ISGs) promotes tumor immune evasion. Here, we identified a long noncoding RNA (lncRNA), VPS9D1-AS1, which was located ribosomes amplified TGF-β signaling ISG expression. We show that VPS9D1-AS1 negatively associated T lymphocyte infiltration two independent cohorts CRC. served as...
Purpose The systemic epidemiology of salt sensitivity (EpiSS) study aims to combine molecular biology, and bioinformatics methods discover the potential causes blood pressure (SSBP) using single-nucleotide polymorphisms in genome non-coding RNAs transcriptome uncover both genetic environmental factors SSBP. Participants Between July 2014 2016, we enrolled adults from 11 centres Beijing Liaoning Province; participants were Han population 35–70 years age. We collected samples, spot urine...