A5108050989- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Venous Thromboembolism Diagnosis and Management
- Viral Infections and Immunology Research
- Cardiac Arrest and Resuscitation
- Air Quality and Health Impacts
- Osteoarthritis Treatment and Mechanisms
- MRI in cancer diagnosis
- Total Knee Arthroplasty Outcomes
- Liver Disease Diagnosis and Treatment
- Infection Control and Ventilation
- Obstructive Sleep Apnea Research
- Animal Disease Management and Epidemiology
- Cardiovascular Health and Disease Prevention
- Hearing, Cochlea, Tinnitus, Genetics
- Cardiovascular Health and Risk Factors
- Bacterial Infections and Vaccines
- Acute Myocardial Infarction Research
- Sugarcane Cultivation and Processing
- Renal cell carcinoma treatment
- Agricultural Engineering and Mechanization
- Knee injuries and reconstruction techniques
- Indoor Air Quality and Microbial Exposure
- Blood Pressure and Hypertension Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Qilu Hospital of Shandong University
2023-2024
Capital Medical University
2018-2024
Second Affiliated Hospital of Dalian Medical University
2023-2024
Beijing Chao-Yang Hospital
2018-2024
University of Science and Technology Beijing
2024
Sir Run Run Shaw Hospital
2022-2024
Zhejiang University
2022-2024
Ministry of Health
2024
Dalian Medical University
2024
Rationale: Dysbiotic gut microbiota (GM) and NLRP3 inflammasome are proarrhythmic factors in atrial fibrillation (AF).Herein, whether short-chain fatty acid (SCFA) produced from GM fermentation of dietary fiber serving as invisible mediators is yet unclear.Thus, the current study aimed to determine SCFA alleviated signaling-mediated remodeling protects AF development.Methods: First, a cross-sectional based on GC-MS metabolomics was performed explore association between fecal levels traits...
In this study, we evaluated the predictive utility of neutrophil percentage-to-albumin ratio (NPAR) for all-cause mortality in patients with chronic heart failure (CHF).Patients diagnosed as CHF enrolled retrospective cohort study were from Beijing Chaoyang Hospital, capital medical university. Admission NPAR was calculated percentage divided by serum albumin. The endpoints defined 90-day, 1-year and 2-year mortality. Multivariable Cox proportional hazard regression model performed to...
Endoplasmic reticulum (ER) stress plays an important role in metabolic diseases like obesity and type 2 diabetes mellitus (T2DM), although the underlying mechanisms regulatory pathways remain to be elucidated. Here, we induced chronic low-grade ER lean mice levels similar those high-fat diet (HFD)–fed obese found that it promoted hyperglycemia due enhanced hepatic gluconeogenesis. Mechanistically, sustained up-regulated deubiquitinating enzyme ubiquitin-specific peptidase 14 (USP14), which...
Intracardiac echocardiography (ICE) technology has been increasingly accepted as an integral part of atrial fibrillation (AF) ablation procedures. It is still unknown whether ICE can routinely replace transesophageal (TEE) for routine thrombus screening in non-selective AF patients.To assess TEE left (LA)/left appendage (LAA) general patients undergoing catheter AF.A total 2003 consecutive were included. 1155 (ICE group) received intra-procedural examination LA/LAA screening, while 848 (TEE...
Abstract Background The causal associations of lipids and the drug target genes with atrial fibrillation (AF) risk remain obscure. We aimed to investigate using genetic evidence. Methods Mendelian randomization (MR) analyses were conducted summary-level genome-wide association studies (GWASs) in European East Asian populations. Lipid profiles (low-density lipoprotein cholesterol, triglyceride, lipoprotein[a]) lipid-modifying (3-hydroxy-3-methylglutaryl-CoA reductase, proprotein convertase...
Physical literacy (PL) is pivotal for improving sedentary behaviors, enhancing intrinsic motivation physical activity, and supporting the growth development of adolescents. This study aims to measure current situation internal pathway PL among Chinese elementary school students. was conducted from June July 2022 used multistage cluster sampling select subjects. Questionnaire measurements were report levels students explain association various dimensions. The average score primary 63.46...
Abstract Aims Cardiovascular diseases, such as atrial fibrillation, coronary artery disease, heart failure (HF) and ischaemic stroke, are leading causes of death globally exert major global health burden. Recent studies suggest that glucagon‐like peptide‐1 receptor agonists (GLP1Ra), a novel class antidiabetic drugs, may not only help manage blood glucose but also reduce the risks cardiovascular diseases. However, mechanisms through which GLP1Ra protects against remain incompletely...
Abstract Autoimmune myocarditis is the limited or diffuse inflammation of myocardium due to dysfunctional cellular and humoral immunity mechanisms. We constructed mouse models experimental autoimmune (EAM) using peptide MyHC-α614-629. On day after secondary immunization, mice were intraperitoneally injected with Rho kinase (ROCK) inhibitor Y-27632. 21, cardiac tissues harvested weighed. The hearts EAM significantly enlarged whitened. Furthermore, body weight (BW) slowly increased during...
Abstract Given that colorectal cancer stem cells (CCSCs) play key roles in the tumor dormancy, metastasis, and relapse, targeting CCSCs is a promising strategy therapy. Here, we aimed to identify new regulators of found Cullin 4B (CUL4B), which possesses oncogenic properties multiple solid tumors, drives development metastasis colon by sustaining stem-like features. Elevated expression CUL4B was confirmed tumors associated with poor overall survival. Inhibition cell lines patient-derived...
To describe the authors' surgical technique and to evaluate final functional outcome of treatment "terrible triad elbow".Eight patients identified with triad" injury patterns, including posterior elbow dislocation, radial head fracture coronoid fracture, were available for a minimum 11 months follow-up. Evaluation was based on Mayo performance, Broberg-Morrey scores, Disabilities Arm, Shoulder Hand (DASH) questionnaire. Complications also recorded.Five elbows redislocated while in splint...
Obesity is usually associated with an increased risk of nonalcoholic fatty liver disease that characterized by accumulation excessive triglyceride (TG) in hepatocytes. However, the factors involved obesity-induced hepatosteatosis are poorly defined. Here, we report SRY-box containing gene 4 (Sox4), a transcription factor regulates cell proliferation and differentiation, plays important role hepatic TG metabolism. Sox4 expression levels markedly upregulated livers obese rodents humans....
Radiofrequency (RF) catheter ablation has emerged as an effective alternative for the treatment of atrial fibrillation (AF), but lesions will result in swelling and hematoma local surrounding tissue, triggering inflammatory cell infiltration increased release cytokines. Some studies have shown that response may be related to early occurrence AF. The most direct way inhibit perioperative inflammation is use anti-inflammatory drugs such glucocorticoids. Here, we prepared polylactic-co-glycolic...
Background: Understanding the levels of health literacy among different groups is essential for better public interventions targeting specific subgroups population. Additionally, this article explores prevalence and influencing factors age during COVID-19 epidemic. Methods: Multistage stratified cluster random sampling Probability Proportion to Size (PPS) method were used select permanent residents aged 15–69 in Chongqing (54,706) questionnaire survey. The survey period from July 2019 2020....
Background: The potential benefit of arthroscopic surgery for osteoarthritic knee associated with medial meniscus tear is controversial. This study was conducted to determine the effect pre-operative extrusion (MME) on outcomes in during a minimum 4-year follow-up. Methods: retrospective review total 131 patients diagnosed symptomatic degenerative who underwent from January 2012 December 2014 and were observed more than 4 years. Patients classified into two groups: MME ≥3 mm (major group, n...
This study examined the effect of sleep disturbance on gut microbiota (GM), atrial substrate, and fibrillation (AF) inducibility. C57BL/6 mice were subjected to six weeks deprivation (SD) using method modified multiple-platform. Transesophageal burst pacing was performed evaluate AF Feces, plasma, an atrium collected analyzed by 16s rRNA sequencing, liquid chromatography–mass spectrometry (LC-MS)-based metabolome, histological studies, transcriptome. Higher inducibility (2/30 control vs....
The present study aimed to describe the characteristics of cystic pancreatic tumors using computed tomography (CT) and evaluate diagnostic accuracy (DA) post‑imaging three‑dimensional (3D) reconstruction. Clinical imaging data, including multi‑slice spiral CT scans, enhanced scans multi‑faceted reconstruction, from 30 patients with pathologically confirmed diagnosed at Linyi People's Hospital between August 2008 June 2014 were retrospectively analyzed. Following injection Ultravist® 300...