A5050819217- Statistical Methods in Clinical Trials
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Optimal Experimental Design Methods
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Metal-Organic Frameworks: Synthesis and Applications
- Electrocatalysts for Energy Conversion
- Crystallography and molecular interactions
- Nanoplatforms for cancer theranostics
- Hepatitis B Virus Studies
- Cancer Immunotherapy and Biomarkers
- Advanced Radiotherapy Techniques
- Monoclonal and Polyclonal Antibodies Research
- Breast Cancer Treatment Studies
- Magnetism in coordination complexes
- Biosimilars and Bioanalytical Methods
- Asymmetric Synthesis and Catalysis
- Advanced battery technologies research
- Asymmetric Hydrogenation and Catalysis
- Gene expression and cancer classification
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Health Systems, Economic Evaluations, Quality of Life
National Clinical Research Center for Digestive Diseases
2022-2024
First Affiliated Hospital Zhejiang University
2020-2024
Soochow University
2018-2024
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2019-2024
Louisiana State University
2015-2024
Qilu University of Technology
2022-2023
Shandong Academy of Sciences
2022-2023
Tianjin University
2023
Institute of Molecular Genetics
2023
Institute of Molecular Medicine
2023
Dynamic reconstruction of catalyst active sites is particularly important for metal oxide-catalyzed oxygen evolution reaction (OER). However, the mechanism how vacancy-induced aids OER remains ambiguous. Here, we use Co3O4 with Co or O vacancies to uncover effects different defects in process and motifs relevant alkaline OER. Combining situ characterization theoretical calculations, found that cobalt oxides are converted an amorphous [Co(OH)6] intermediate state, then mismatched rates *OH...
Early determination of the prognosis patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) is important to guide clinical management and decrease mortality. The aim this study was develop a new simplified prognostic score accurately predict outcomes in HBV-ACLF.Prospective data from 2,409 hospitalized acute deterioration HBV-related chronic disease were used that validated an external group.A total 954 enrolled HBV-ACLF diagnosed based on Chinese Group Study...
Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) pathophysiology remains unclear. This study aims to characterise the molecular basis of HBV-ACLF using transcriptomics.Four hundred subjects with HBV-ACLF, hepatic dysfunction (ACHD), cirrhosis (LC) or chronic hepatitis (CHB) and normal controls (NC) from a prospective multicentre cohort were studied, 65 (ACLF, 20; ACHD, 10; LC, CHB, NC, 15) among them underwent mRNA sequencing peripheral blood mononuclear cells (PBMCs).The...
Abstract As sustainable energy becomes a major concern for modern society, renewable and clean systems need highly active, stable, low-cost catalysts the oxygen evolution reaction (OER). Mesoporous materials offer an attractive route generating efficient electrocatalysts with high mass transport capabilities. Herein, we report hard templating pathway to design synthesize three-dimensional (3-D) mesoporous ternary nickel iron nitride (Ni3FeN). The as-synthesized electrocatalyst shows good OER...
Livestock wastewater is an important source of agricultural non-point pollution, causes serious pollution to water bodies. At the same time, corn straw also waste, and its resource utilization has been focus global attention. The novel biochar material made from stalk can be used treat livestock wastewater, which helpful control improve efficiency waste utilization. A chitosan modified magnesium impregnated (CS-MgCBC) was synthetic for removal NH4+-N PO43−-P wastewater. experiments results...
Triple-negative breast cancer (TNBC) due to lack of clear target and notorious "cold" tumor microenvironment (TME) is one the most intractable lethal malignancies. Tuning TME into "hot" becomes an emerging therapeutic strategy TNBC. Herewith, we report that integrin-targeting micellar gemcitabine paclitaxel (ATN-mG/P, ATN sequence: Ac-PhScNK-NH2) cooperating with polymersomal CpG (NanoCpG) effectively "heated up" treated ATN-mG/P exhibited greatly boosted apoptotic activity in 4T1 cells,...
Abstract In the era of targeted therapy, there has been increasing concern about development oncology drugs based on “more is better” paradigm, developed decades ago for chemotherapy. Recently, US Food and Drug Administration (FDA) initiated Project Optimus to reform dose optimization selection paradigm in drug development. To accommodate this shifting, we propose a dose-ranging approach optimizing (DROID) trials with drugs. DROID leverages well-established study framework, which routinely...
The newly designed organic ligand 2-(p-bromophenyl)-1H-imidazole-4,5-dicarboxylic acid (p-BrPhH3IDC) has been successfully prepared and its coordination features were explored. By the reactions of p-BrPhH3IDC with main group or transition metals, six metal–organic frameworks (MOFs), namely, [Ca(p-BrPhHIDC)(H2O)2]n (1), [Sr(p-BrPhHIDC)(H2O)]n (2), [Zn(p-BrPhHIDC)(H2O)]n (3), {[Co(p-BrPhH2IDC)2]·2H2O}n (4), [Cd1.5(p-BrPhHIDC)(p-BrPhH2IDC)(H2O)]n (5), {[Cd2(p-BrPhHIDC)2(4,4′-bipy)]·4H2O}n...
For specific application to an uncooled infrared detector, VO2 thin films should have a series of characteristics including purposefully chosen polymorphs, accurate stoichiometry, phase stabilization, high temperature-coefficient resistance (TCR), and suitable square-resistance. This work reports controllable preparation high-performance via post annealing sandwich-structured V2O5/metal (V, W)/V2O5 multilayer precursor, which was deposited by RF magnetron sputtering. sandwich structure can...
Nitrile hydration provides access to amides that are important structural elements in organic chemistry. Here we report catalytic nitrile using ruthenium catalysts based on a pincer scaffold with dearomatized pyridine backbone. These complexes catalyze the nucleophilic addition of H2O wide variety aliphatic and (hetero)aromatic nitriles t BuOH as solvent. Reactions occur under mild conditions (room temperature) absence additives. A mechanism for is proposed initiated by metal-ligand...
The optimal dose for treating patients with a molecularly targeted agent may differ according to the patient's individual characteristics, such as biomarker status. In this article, we propose Bayesian phase I/II dose-finding design find that is personalized each patient his/her To overcome curse of dimensionality caused by relatively large number biomarkers and their interactions dose, employ canonical partial least squares (CPLS) extract small components from covariate matrix containing...
Highly active porous FeCo/carbon oxygen electrocatalysts with well-defined multiple sites have been prepared <italic>via</italic> a scalable mechanochemical route, which perform better than precious metal Pt/C and RuO<sub>2</sub> in rechargeable Zn–air batteries.
Abstract The development of Pt‐free catalysts for the alkaline hydrogen evolution reaction (HER), which is widely used in industrial scale water‐alkali electrolyzers, remains a contemporary and pressing challenge. Ruthenium (Ru) has excellent water‐dissociation abilities could be an alternative water splitting catalyst. However, its large binding energy limits HER activity. Here, new approach proposed to boost activity Ru through uniform loading nanoparticles on triazine‐ring (C 3 N )‐doped...
A bimetallic ZnCo-ZIF@graphene oxide (ZnCo-ZIF@GO) composite was synthesized<italic>via</italic>an<italic>in situ</italic>growth strategy. As the air cathode of Zn–air batteries, ZnCo-ZIF@GO showed good charge/discharge performance and long-term stability.
Biodegradable nanostructures displaying aggregation-induced emission (AIE) are desirable from a biomedical point of view, due to the advantageous features loading capacity, brightness, and fluorescence stability. Herein, biodegradable polymers comprising poly (ethylene glycol)-block-poly(caprolactone-gradient-trimethylene carbonate) (PEG-P(CLgTMC)), with tetraphenylethylene pyridinium-TMC (PAIE) side chains have been developed, which self-assembled into well-defined polymersomes. The...
Abstract The prolonged start-up time and low total nitrogen removal of anammox hinder its full-scale application. Herein, application nano-zerovalent iron strength magnetic field in sole combination to abbreviate the period long-term process stability was carried out. reactor’s with only (R3) 34 days, saving 43.3% compared control. increase efficiency over control 43.7% during period. However, reactor coupled treatment (R4) more stable higher (80%) at high loading (5.28 kg/m 3 /d). Anammox...
Abstract Background The key role of thrombospondin 1 (THBS1) in the pathogenesis acute-on-chronic liver failure (ACLF) is unclear. Here, we present a transcriptome approach to evaluate THBS1 as potential biomarker ACLF disease pathogenesis. Methods Biobanked peripheral blood mononuclear cells (PBMCs) from 330 subjects with hepatitis B virus (HBV)-related etiologies, including HBV-ACLF, cirrhosis (LC), and chronic (CHB), normal controls (NC) randomly selected Chinese Group on Study Severe...
Diastereo- and enantioselective preparation of 2,2-disubstituted benzofuran-3(2H)-one has been realized by a pybox-copper catalyzed reaction between 2-substituted propargyl acetate. The utility this method was demonstrated further transformation the terminal alkyne into methyl ketone without loss enantiomeric purity.