A5071903151- Acute Myeloid Leukemia Research
- RNA modifications and cancer
- Chronic Myeloid Leukemia Treatments
- Semiconductor materials and devices
- Ferroelectric and Negative Capacitance Devices
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Advancements in Semiconductor Devices and Circuit Design
- RNA Research and Splicing
- Cancer-related gene regulation
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Advanced DC-DC Converters
- Silicon Carbide Semiconductor Technologies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Multilevel Inverters and Converters
- Bone health and treatments
- MXene and MAX Phase Materials
- Biological Research and Disease Studies
- Advanced Battery Technologies Research
- Parathyroid Disorders and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
- Acute Lymphoblastic Leukemia research
- Hematological disorders and diagnostics
- Pharmacological Effects and Toxicity Studies
Zhejiang University
2011-2024
First Affiliated Hospital Zhejiang University
2022-2024
Cell Technology (China)
2024
Zhejiang Chinese Medical University
2023
East China Normal University
2023
State Key Laboratory of Silicon Materials
2016-2022
Sir Run Run Shaw Hospital
2022
Hangzhou Red Cross Hospital
2020
Nanjing University
2016
Abstract N6-methyladenosine (m6A), the most abundant modification in mRNAs, has been defined as a crucial modulator progression of acute myelogenous leukemia (AML). Identification key regulators m6A modifications AML could provide further insights into biology and uncover more effective therapeutic strategies for patients with AML. Here, we report overexpression YTHDF1, an reader protein, human samples at protein level enrichment stem cells (LSC). Whereas YTHDF1 was dispensable normal...
A high-efficiency fuel-cell power-generation system with an active-clamp flyback-forward converter is presented in this paper to boost a 12-V dc voltage into 220-V 50-Hz ac voltage. The proposed includes high-step-up interleaved soft-switching and full-bridge inverter. front-end has the advantages of zero-voltage-switching performance for all primary switches, reverse-recovery-problem alleviation secondary output diodes, large voltage-conversion ratio, small input-current ripple....
Intracardiac echocardiography (ICE) technology has been increasingly accepted as an integral part of atrial fibrillation (AF) ablation procedures. It is still unknown whether ICE can routinely replace transesophageal (TEE) for routine thrombus screening in non-selective AF patients.To assess TEE left (LA)/left appendage (LAA) general patients undergoing catheter AF.A total 2003 consecutive were included. 1155 (ICE group) received intra-procedural examination LA/LAA screening, while 848 (TEE...
In this letter, we systematically studied the relationship between ferroelectricity/anti-ferroelectricity and corresponding phase structures in Hf1-xZrxO2 (HZO) films. Our findings, obtained through ab initio simulations, indicate that orthorhombic-I exhibits greater stability compared to orthorhombic-III tetragonal phases HZO system. Atomic-resolution C s-corrected scanning transmission electron microscopy revealed a direct correlation anti-ferroelectricity materials. Furthermore,...
AML1/ETO fusion confers favorable prognosis in acute myeloid leukemia (AML) treated with intensive chemotherapy (IC). However, the impact of on efficacy venetoclax treatment AML is unclear. The aim this study was to evaluate plus hypomethylating agents (VEN/HMAs) patients AML1/ETO-positive AML. Patients newly diagnosed two centers were reviewed and divided into three cohorts: frontline VEN/HMA (Cohort A), AML1/ETO-negative B), or IC C). response survival compared between cohorts. A total 260...
Abstract Background The prognostic significance of myelofibrosis (MF) grade in patients with myelodysplastic syndrome (MDS) following an allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains elusive. Methods We retrospectively analyzed data from 153 MDS who underwent allo-HSCT and divided the into MF-0/1 (N = 119) MF-2/3 34) cohorts to explore impact MF on outcomes allo-HSCT. Results 2-year rates relapse, non-relapse mortality (NRM), overall survival (OS), progression-free...
In this work, we present the first observation of random telegraph noise (RTN) in ultra-scaled Ge nanowire (NW) nMOSFETs. The impacts NW geometry, channel length, EOT, and doping on low frequency are studied comprehensively. It is confirmed that with 1/f characteristics attributed to mobility fluctuation decreases when length scales down from 80 nm 40 because near-ballistic transport electrons.
A novel converter with switched capacitor and voltage gain extension cell is proposed in this paper to satisfy the high requirements. In converter, applied extend reduce stress of switch. circuit adopted further improve conversion ratio. Meanwhile, leakage inductance coupled inductors limits current rate, which reduces pulsed significantly when switch turns on. Furthermore, energy absorbed transferred load, clamped it off by capacitor. Finally, a 48V-input 380V-output 500W prototype built...
This study aims to assess the impact of nationwide Omicron outbreak in December 2022 on Chinese patients with plasma cell disorders (PCD), focusing clinical characteristics PCD COVID-19 and risk factors contributing adverse courses (severity hospitalization) outcomes.
ABSTRACT N6-methyladenosine (m 6 A), the most abundant modification in mRNAs, has been defined as a crucial modulator progression of acute myeloid leukemia (AML), while detailed mechanism remains elusive. Here we report that YTHDF1, an m A reader protein, is overexpressed human AML samples with enrichment stem cells (LSCs). Whereas YTHDF1 dispensable for normal hematopoiesis mice, depletion attenuates self-renewal and proliferation patient-derived LSCs, impedes establishment immunodeficient...
<div>Abstract<p>N<sup>6</sup>-methyladenosine (m<sup>6</sup>A), the most abundant modification in mRNAs, has been defined as a crucial modulator progression of acute myelogenous leukemia (AML). Identification key regulators m<sup>6</sup>A modifications AML could provide further insights into biology and uncover more effective therapeutic strategies for patients with AML. Here, we report overexpression YTHDF1, an reader protein, human samples at...
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