A5102895201- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Neutropenia and Cancer Infections
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- CAR-T cell therapy research
- Retinoids in leukemia and cellular processes
- Pneumocystis jirovecii pneumonia detection and treatment
- Immune cells in cancer
- Renal Transplantation Outcomes and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Immunodeficiency and Autoimmune Disorders
- Histone Deacetylase Inhibitors Research
- Antibiotic Resistance in Bacteria
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Lymphoma Diagnosis and Treatment
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Mast cells and histamine
- T-cell and B-cell Immunology
- Cancer Risks and Factors
Fujian Medical University
2023-2025
Union Hospital
2025
Zhejiang Provincial People's Hospital
2009-2024
Hangzhou Medical College
2018-2023
Zhejiang University
2004-2009
First Affiliated Hospital Zhejiang University
2008
A combination of anti-B-cell maturation antigen (BCMA) and anti-CD19 chimeric receptor (CAR) T cells induced high response rates in patients with relapsed or refractory (R/R) multiple myeloma (MM), but long-term outcomes have not been assessed yet.In this single-arm, phase II trial, R/R MM received a anti-BCMA CAR at dose 1 × 106 cells/kg, after receiving conditioning chemotherapy consisting cyclophosphamide fludarabine. The overall response, outcomes, safety were assessed, as their...
<b><i>Background/Aim:</i></b> As the knowledgebase of acute myeloid leukemia (AML) has grown, classification systems have moved to incorporate these new findings. <b><i>Methods:</i></b> We assessed 32,941 patients with AML whose records are contained in Surveillance, Epidemiology, and End Results (SEER) database. <b><i>Results:</i></b> Half all diagnosed between 2001 2013 did not a World Health Organization (WHO)...
Acute graft versus host disease (aGVHD) remains a major problem after allogeneic hematopoietic stem cell transplantation. Standard frontline therapy for aGVHD involves corticosteroids. However, fewer than half of patients have lasting complete response. The long-term mortality rate steroid-refractory (SR-aGVHD) around 70%. To date, no consensus has been reached regarding the optimal salvage treatment SR-aGVHD. We performed first prospective, multi-center clinical trial to assess efficacy and...
Most randomized trials for acute promyelocytic leukemia (APL) have investigated highly selected patients under idealized conditions, and the findings need to be validated in real world. We conducted a population-based study of all APL Zhejiang Province, China, with total population 82 million people, assess generalization all-trans retinoic acid (ATRA) arsenic as front-line treatment. The outcomes were also analyzed. Between January 2015 December 2019, 1,233 eligible included final analysis....
Abstract Background Although the prognosis of Philadelphia‐positive acute lymphoblastic leukemia (Ph+ ALL) has improved with introduction tyrosine kinase inhibitors (TKIs) and stem cell transplantation, prevention relapse after transplantation remains a concern. The aim this study was to compare impact TKI prophylaxis imatinib dasatinib on long‐term outcomes transplantation. Methods Patients Ph+ ALL who underwent allogeneic hematopoietic (allo‐HSCT) at first complete remission (CR1) received...
To evaluate the efficacy and prognostic factors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in patients with secondary acute myeloid leukemia (sAML) .
The promyelocytic leukemia (PML) protein is a major component to govern the PML nuclear body (NB) assembly and function. Although it well defined that NB site recruiting sumoylated proteins, mechanism by which regulates process remains unclear. Here we show PML3, specific isoform, interacts with recruits TIP60 NBs. Our biochemical characterization demonstrates PML3 physically via its N-terminal 364 amino acids. Importantly, this portion of sufficient target NBs, suggesting PML3-TIP60...
About half of patients with severe acute graft vs host disease (aGVHD) show resistance to treatment first-line steroids. We enrolled 64 grades III-IV SR-aGVHD after allogeneic hematopoietic stem cell transplantation (allo-SCT), assess the efficacy and safety combination therapy ruxolitinib etanercept. The overall response rate was 87.5% (95% CI, 79.7%-95.3%) at day 28 treatment, from which 73.4% reached complete (CR). A marked reduction ≥75% in daily corticosteroid dosing documented 75.4%...
Background: Candida tropicalis is the most common non-albicans species identified in immunocompromised patients, which often appears with high mortality. However, data on outcomes of treatment for fungemia patients neutropenia remain limited. Methods: In present study, 90 neutropenic adult proven fungemia, who received initial antifungal therapy, were retrospectively analyzed. Results: These results revealed that overall 8-day and 30-day mortality among entire set 22.2% 33.3%, respectively....
CD19-targeted chimeric antigen receptor T (CAR-T) cells using murine single-chain variable fragment (scFv) has shown substantial clinical efficacy in treating relapsed/refractory acute lymphoblastic leukemia (R/R ALL). However, potential immunogenicity of the scFv domain may limit persistence CAR-T cells. In this study, we treated 52 consecutive subjects with R/R ALL humanized CD19-specific (hCART19s). Forty-six achieved complete remission (CR) (N = 43) or CR incomplete count recovery (CRi)...
Abnormal expressions of long noncoding RNAs (lncRNAs) and protein-encoding messenger (mRNAs) are important for the development childhood acute lymphoblastic leukemia (ALL). This study developed an lncRNA-mRNA integrated classifier prediction recurrence prognosis in relapsed ALL by using several transcriptome data. Weighted gene coexpression network analysis revealed that green, turquoise, yellow, brown modules were preserved across TARGET, GSE60926, GSE28460, GSE17703 datasets, they...
The purpose of this prospective, multi-center study was to examine the efficacy and safety tigecycline as empirical treatment in neutropenic patients with hematological malignancies who failed respond first-line antibiotics. A total 125 persistent fever (>72 h) despite antibiotics received (loading dose 100 mg, followed by 50 mg every 12 h). use other antimicrobial agents not restricted. Treatment success rate 68.0%. Subgroup analysis revealed a 73.1% pneumonia 35.3% bacteremia. Toxicities...
Abstract Common variable immunodeficiency (CVID) was a kind of primary disorders with heterogeneous phenotype and genotype. Lipopolysaccharide-responsive beige-like anchor (LRBA) mutation identified as disease associated in CVID, advanced genetic method will help to detect atypical cases. We report case adult patient manifested hemophagocytic lymphohistiocytosis (HLH), bone marrow examination suggested prosperity MDS, increased immature myeloid cells dysplastic hematopoiesis. Whole exome...
Abstract Patients with acute myeloid leukemia (AML) evolving from myelodysplastic syndrome (MDS) or higher‐risk MDS have limited treatment options and poor prognosis. Our previous single‐center study of decitabine followed by low dose idarubicin cytarabine (D‐IA) in patients neoplasms showed promising primary results. We therefore conducted a multicenter D‐IA regimen AML MDS. refractory anemia excess blasts type 2 (RAEB‐2) (based on the 2008 WHO classification) were included. The...
Background: Mast cell leukemia (MCL) is a highly life-threatening and extremely rare subtype of systemic mastocytosis (SM). MCL often genetically contains one or more somatic mutations, particularly activating mutations KIT . This study reported on an acute patient who had phenotype genetic mutants with history primary malignant mediastinal germ tumor (GCT). Case Presentation: A 30-year-old Asian male underwent two rounds surgery chemotherapy GCT (PM-GCTs) was admitted to our hospital due...