A5044547848- Lymphoma Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Multiple Myeloma Research and Treatments
- Fungal Infections and Studies
- COVID-19 Clinical Research Studies
- Neutropenia and Cancer Infections
- Acute Myeloid Leukemia Research
- Platelet Disorders and Treatments
- Retinoids in leukemia and cellular processes
- Pneumocystis jirovecii pneumonia detection and treatment
- Blood groups and transfusion
- Ubiquitin and proteasome pathways
- Cancer Treatment and Pharmacology
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Acute Lymphoblastic Leukemia research
- COVID-19 and healthcare impacts
- Antibiotic Resistance in Bacteria
- Ferroptosis and cancer prognosis
- Respiratory viral infections research
- Chronic Lymphocytic Leukemia Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Drug-Induced Ocular Toxicity
Hangzhou First People's Hospital
2013-2024
Zhejiang University
2019-2024
Westlake University
2024
Zhejiang Chinese Medical University
2022
Xuzhou No.1 People's Hospital
2009
Xuzhou Medical College
2009
City Of Hope National Medical Center
2005
At present, GPX4's role in the occurrence and development of diffuse large B lymphoma (DLBCL) is rarely reported. This study's purpose to explore significance diagnosis, treatment, pathological mechanisms DLBCL. The TIMER 2.0, GEPIA, GEO databases were used analyze expression levels DLBCL tissue, peripheral blood, single cells, evaluate its potential performance as a therapeutic diagnostic marker. Cell experiments validate cells. And revealed mechanism action from three aspects: immunity,...
Multiple myeloma (MM) is an incurable hematological malignancy that lacks effective therapeutic interventions. Ferroptosis a newly discovered form of cell death has shown great potential for MM therapy. As proteasome inhibitor and necroptosis inducer, shikonin (SHK) performs dual functions in cells. However, whether SHK inhibits the development via ferroptosis or any other mechanism remains elusive. Here, we provide evidence treatment was capable inducing immunogenic (ICD) MM. The results...
The responses of intravenous immunoglobulin (IVIg) or corticosteroids as the initial treatment on pregnancy with ITP were unsatisfactory. This study aimed to assess safety and effectiveness prednisone plus IVIg versus in pregnant patients immune thrombocytopenia (ITP).Between 1 January 2010 31 December 2020, 970 pregnancies diagnosed at 19 collaborative centers China reviewed this observational study. A total 513 (52.89%) received no intervention. Concerning remaining pregnancies, 151...
Chronic mucocutaneous candidiasis (CMC) is a disorder of recurrent or persistent chronic noninvasive symptomatic infections the skin, nails and mucous membranes. This primarily caused by Candida albicans . Many factors, including primary immunodeficiencies, can make host more susceptible to CMC. Signal transducer activator transcription 1 (STAT1) gain-of-function (GOF) mutations are most common genetic etiologies We describe case CMC with disseminated Talaromyces marneffei infection new...
Acute promyelocytic leukemia (APL) is a rare characterized by the balanced reciprocal translocation between gene on chromosome 15 and retinoic acid receptor α (RARα) 17, accounts for 10‑15% of newly diagnosed acute myeloid each year. The combined use all‑trans arsenic trioxide (ATO) as primary therapy has markedly improved survival rate patients with APL. Mortality in first 30 days following remains major contribution to treatment failure. In present study, published data was reviewed focus...
Abstract Globally, postpartum hemorrhage (PPH) is the leading cause of maternal death. Women with immune thrombocytopenia (ITP) are at increased risk developing PPH. Early identification PPH helps to prevent adverse outcomes, but underused because clinicians do not have a tool predict for women ITP. We therefore conducted nationwide multicenter retrospective study develop and validate prediction model in patients included 432 pregnant (677 pregnancies) primary ITP from 18 academic tertiary...
Since the discovery of copper induces cell death(cuprotosis) in 2022, it has been one biggest research hotspots. cuprotosis related genes (CRGs) demonstrated to be a potential therapeutic target for cancer, however, molecular mechanism CRGs coronavirus disease 2019 (COVID-19) infected DLBCL patients not reported yet. Therefore, our objective is first elucidate and role COVID-19. Secondly, we conducted univariate multivariate analysis machine learning screen with common expression differences...
Cuprotosis related genes (CRGs) have been proved to be potential therapeutic targets for coronavirus disease 2019 (COVID-19) and cancer, but their immune molecular mechanisms in COVID-19 infection Diffuse Large B-cell Lymphoma (DLBC/DLBCL) patients are rarely reported. Our research goal is first screen the key CRGs through univariate analysis, machine learning clinical samples. Secondly, we determined expression prognostic role of DLBCL pan-cancer analysis. We validated levels prognosis...
Abstract The tumor microenvironment plays an important role in various processes, including tumorigenesis, cancer progression, and metastasis. Immune signatures have been identified verified for use diagnosis prognosis prediction. We used single-sample Gene Set Enrichment Analysis to evaluate immune cell infiltration score (TIICs) verify their prognostic significance both training validation cohorts using this information build a model. A total of 1281 samples were obtained further...
The current study presents the case of a 9-year-old Chinese boy who presented with eosinophilia and elevated serum levels immunoglobulin G4 (IgG4). A bone marrow puncture identified an eosinophil rate 23% (normal range, <5%), which indicated eosinophilia. However, gene analysis, fluorescent in situ hybridization other examinations, including aspiration, blood routine, auto-antibody tests parasitic allergens screening, contradicted diagnosis secondary or clonal Furthermore, patient exhibited...
Background: Candida tropicalis is the most common non-albicans species identified in immunocompromised patients, which often appears with high mortality. However, data on outcomes of treatment for fungemia patients neutropenia remain limited. Methods: In present study, 90 neutropenic adult proven fungemia, who received initial antifungal therapy, were retrospectively analyzed. Results: These results revealed that overall 8-day and 30-day mortality among entire set 22.2% 33.3%, respectively....
Lichen myxedematosus (LM) is an idiopathic cutaneous mucinosis disorder, and monoclonal gammopathy of undetermined significance (MGUS) a preneoplastic plasma cell disease with increase in globulin. Patients LM combined are normally diagnosed scleromyxedema. However, we report case generalized papules MGUS 78-year-old man who was eventually atypical or intermediate forms because it only involved the skin, pathological type not consistent Few cases have been reported, so course unpredictable....
The aim of this study was to investigate the fibroblast growth factor receptor 3 (FGFR3) mRNA cleavage by ribozymes targeting FGFR3, effect inhibition and associated with mechanism on multiple myeloma (MM). We designated two ribozyme-expressing plasmids that target FGFR3 genes, Rz52 Rz32. In vitro catalytic activity Rz32 in KMS11 cells decreased expression 45% (p < 0.05) 80% 0.5), respectively, control. vivo examination Rz52-transfected clone showed 20% H929 clone, 50% Protein 70% parental...
Mucormycosis is an angioinvasive fungal infection with a high mortality rate. Patients hematological malignancies following voriconazole therapy are at risk from mucormycosis. Here, the present study reports on 68-year-old man diagnosed multiple myeloma and secondary myelodysplastic syndrome, who was infected disseminated mucormycosis cerebellum involvement confirmed by mycological culture histopathological examination. For patients receiving antifungal therapy, opportunistic of should be...
To evaluate the effect of intestinal carbapenem-resistant Enterobacteriaceae (CRE) active screening combined with enhanced intervention in prevention and control nosocomial infection patients admitted to hematological ward.
Hepatosplenic T cell lymphoma (HSTCL) is a particularly difficult-to-treat form of lymphoma, with many patients exhibiting primary resistance to chemotherapy. At present, no effective strategy for treating relapsed and refractory HSTCL has been established, treatment being hampered by questions how best overcome chemoresistance allow attain more durable therapeutic benefits. While there have marked advances in immunotherapy, allogeneic hematopoietic stem transplantation (allo-HSCT) remains...
To evaluate the efficacy and safety of hypomethylating agents (HMA) in patients with myelodysplastic syndromes (MDS) .