A5100761810- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Knee injuries and reconstruction techniques
- Sports injuries and prevention
- Orthopedic Surgery and Rehabilitation
- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Viral gastroenteritis research and epidemiology
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Lanthanide and Transition Metal Complexes
- Connective tissue disorders research
- Hepatitis Viruses Studies and Epidemiology
- Electrospun Nanofibers in Biomedical Applications
- Scoliosis diagnosis and treatment
- Spine and Intervertebral Disc Pathology
- Foot and Ankle Surgery
- Wound Healing and Treatments
- CAR-T cell therapy research
- Spinal Fractures and Fixation Techniques
- Advanced Battery Materials and Technologies
- Bone and Dental Protein Studies
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Total Knee Arthroplasty Outcomes
Second Affiliated Hospital of Zhejiang University
2023-2025
Xiangya Hospital Central South University
2015-2025
Central South University
2015-2025
Huazhong University of Science and Technology
2022-2025
Tongji Hospital
2025
Soil and Fertilizer Institute of Hunan Province
2019-2025
Soochow University
2021-2025
Nanjing Medical University
2025
Suzhou Municipal Hospital
2025
Shanghai Power Equipment Research Institute
2025
Rotavirus is the leading global pathogen of diarrhea-associated mortality and poses a great threat to public health in all age groups. This study aimed explore burden 30-year change patterns rotavirus infection-associated deaths.Based on Global Burden Disease 2019 Study (GBD 2019), we analyzed age-standardized death rate (ASDR) infection by sex, geographical region, sociodemographic index (SDI) from 1990 2019. A Joinpoint regression model was used analyze trends over 30 years, SaTScan...
Background: Osteoarthritis is the leading cause of disability worldwide; cartilage degeneration and defects are central features. Significant progress in tissue engineering holds promise to regenerate damaged tissue. However, a formidable challenge develop 3-dimensional (3D) construct that can regulate local immune environment facilitate intrinsic osteochondral regeneration. Purpose: To evaluate efficacy 3D-printed decellularized extracellular matrix (ECM) polyethylene glycol diacrylate...
It is well known that appropriate mechanical stimulation benefits tendon-bone (T-B) healing, however, the mechanisms behind this are still uncovered completely. Here, we aimed to explore whether IL-4/JAK/STAT signaling pathway mediated macrophage polarization was involved in induced T-B healing.C57BL/6 mice rotator cuff (RC) repair model established, and were randomly allocated following group. 1. Mice allowed for free cage activities after surgery (FC group); 2. received treadmill running...
Rotator cuff (RC) attaches to humerus across a triphasic yet continuous tissue zones (bone-fibrocartilage-tendon), termed "enthesis". Regrettably, rapid and functional enthesis regeneration is challenging after RC tear. The existing grafts bioengineered for repair are insufficient, as they were engineered by scaffold that did not mimic normal in morphology, composition, tensile property, meanwhile cannot simultaneously stimulate the formation of bone-fibrocartilage-tendon tissues. Herein, an...
ObjectiveUnderstanding the global patterns of respiratory syncytial virus (RSV) is crucial for developing effective prevention and control strategies.MethodsData on RSV-related burden were extracted from Global Burden Disease 2019. Joinpoint regression models used to assess temporal trends RSV further stratified analyses conducted according Socio-demographic Index (SDI), which a composite measure income, education, total fertility. Age-period-cohort model was evaluate age, period, cohort...
Due to increasing morbidity worldwide, fractures are becoming an emerging public health concern. This study aimed investigate the effect of metformin on healing osteoporotic as well normal fractures. Type H vessels have recently been identified a bone-specific vascular subtype that supports osteogenesis. Here, we show accelerated fracture in both and mice. Moreover, promoted angiogenesis vitro under hypoxia type vessel formation throughout healing. Mechanistically, increased expression...
Due to overactive inflammation and hindered angiogenesis, self-healing of diabetic wounds (DW) remains challenging in the clinic. Platelet-derived exosomes (PLT-Exos), a novel exosome capable anti-inflammation pro-angiogenesis, show great potential DW treatment. However, previous administration into skin is topical daub or intradermal injection, which cannot intradermally deliver PLT-Exos dermis layer, thus impeding its long-term efficacy pro-angiogenesis. Herein, dissolvable...
Background: After surgical repair of rotator cuff (RC) tears, the torn tendon heals unsatisfactorily to greater tuberosity owing limited regeneration bone-tendon (BT) insertion. This situation motivates need for new interventions enhance BT healing in RC site. Purpose: To develop injectable fibrocartilage-forming cores by tethering fibroblast growth factor 18 (FGF18) on acellular fibrocartilage matrix microparticles (AFM-MPs) and evaluate their efficacy healing. Study Design: Controlled...
Functional fibrocartilage regeneration is a bottleneck during bone-tendon healing, and the currently available tissue-engineering strategies for are insufficient because of lack appropriate scaffold that can load large seeding-cells induce chondrogenesis stem cells. The acellular (AFS) contains active growth factors as well tissue-specific epitopes cell-matrix interactions, which make it potential tissue-engineered fibrocartilage. A limitation to this its low porosity inhibits cells loading...
After anterior cruciate ligament (ACL) reconstruction in clinic, firm and rapid integration of the grafted tendon into bone tunnel remains a challenge. Exosomes from hypoxia-treated stem cells are beneficial for promoting angiogenesis then coupling with osteogenesis. Therefore, exosomes hypoxia-cultured bone-marrow mesenchymal (Hypo-Exos) may be cell-free therapy enhancing graft-bone incorporation after ACL reconstruction.Exosomes normoxia-cultured (Norm-Exos) or Hypo-Exos were respectively...
Abstract In order to repair critical‐sized bone defects, various polylactic acid‐glycolic acid (PLGA)‐based hybrid scaffolds are successfully developed as substitutes. However, the byproducts of these PLGA‐based known acidify implanted site, inducing tiresome acidic inflammation. Moreover, degradation productions cannot offer an osteo‐friendly microenvironment at matching natural healing. Herein, inspired by atlas bone‐healing process, osteo‐microenvironment stage‐regulative scaffold...
Background: Low-intensity pulsed ultrasound stimulation (LIPUS) has been proven to be a beneficial biophysical therapy for tendon-bone (T-B) healing. However, the optimal time initiate LIPUS treatment not determined yet. initiated at different stages of inflammatory phase may profoundly affect T-B Purpose: An established rabbit model was used preliminarily investigate effect initiation timing on Study Design: Controlled laboratory study. Methods: A total 112 mature rabbits that underwent...
This study aimed to investigate region-specific epidemiologic characteristics of influenza and transmission zones (ITZs).Weekly surveillance data 156 countries from 1996 2021 were obtained using FluNet. Joinpoint regression was used describe global virus trends, clustering analyses classify the ITZs.The median average positive rate for total 16.19% (interquartile range: 11.62-25.70%). Overall, three major subtypes (influenza H1, H3, B viruses) showed alternating epidemics. Notably,...
ABSTRACT The purpose of this study was to explore the effect low‐intensity pulsed ultrasound (LIPUS) treatment initiating after inflammation stage on process bone‐tendon junction (BTJ) healing in a rabbit model. Thirty‐six rabbits undergoing partial patellectomy were randomly divided into two groups: control and LIPUS. period initial inflammatory is 2 weeks. So LIPUS initiated at postoperative week continued until patella‐patellar tendon (PPT) complexes harvested weeks 4, 8, 16. At each time...
Abstract Periosteal stem cells are critical for bone regeneration, while the numbers will decrease with age. This study focused on whether Prx1 + cell, a kind of periosteal could stimulate regeneration in aged mice. Four weeks and 12 months old Prx1CreER‐GFP; Rosa26 tdTomato mice were used to reveal degree participating femoral fracture healing procedure. One week, 8 weeks, 24 Prx1CreER‐GFP analyse real‐time distribution cells. Twelve C57BL/6 male (n = 96) create defect model and,...